XML 9 R1.htm IDEA: XBRL DOCUMENT v3.25.3
Document and Entity Information - shares
 9 Months Ended
Sep. 30, 2025
Oct. 29, 2025
Cover [Abstract]    
Entity Registrant Name PLUS THERAPEUTICS, INC.  
Entity Central Index Key 0001095981  
Current Fiscal Year End Date --12-31  
Entity Filer Category Non-accelerated Filer  
Entity Emerging Growth Company false  
Entity Small Business true  
Entity Common Stock, Shares Outstanding   137,429,055
Document Fiscal Year Focus 2025  
Document Fiscal Period Focus Q3  
Document Type 10-Q  
Amendment Flag false  
Document Period End Date Sep. 30, 2025  
Document Quarterly Report true  
Document Transition Report false  
Entity Interactive Data Current Yes  
Entity Current Reporting Status Yes  
Entity Shell Company false  
Trading Symbol PSTV  
Title of 12(b) Security Common Stock, par value $0.001  
Security Exchange Name NASDAQ  
Entity File Number 001-34375  
Entity Incorporation, State or Country Code DE  
Entity Tax Identification Number 33-0827593  
Entity Address, Address Line One 2710 REED ROAD  
Entity Address, Address Line Two SUITE 160  
Entity Address, City or Town HOUSTON  
Entity Address, State or Province TX  
Entity Address, Postal Zip Code 77051  
City Area Code 737  
Local Phone Number 255-7194