<SEC-DOCUMENT>0001140361-25-011284.txt : 20250331
<SEC-HEADER>0001140361-25-011284.hdr.sgml : 20250331
<ACCEPTANCE-DATETIME>20250331160152
ACCESSION NUMBER:		0001140361-25-011284
CONFORMED SUBMISSION TYPE:	RW
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20250331
DATE AS OF CHANGE:		20250331

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PLUS THERAPEUTICS, INC.
		CENTRAL INDEX KEY:			0001095981
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		EIN:				330827593
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		RW
		SEC ACT:		
		SEC FILE NUMBER:	333-275712
		FILM NUMBER:		25793027

	BUSINESS ADDRESS:	
		STREET 1:		4200 MARATHON BLVD.
		STREET 2:		SUITE 200
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78756
		BUSINESS PHONE:		737.255.7194

	MAIL ADDRESS:	
		STREET 1:		4200 MARATHON BLVD.
		STREET 2:		SUITE 200
		CITY:			AUSTIN
		STATE:			TX
		ZIP:			78756

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CYTORI THERAPEUTICS, INC.
		DATE OF NAME CHANGE:	20050712

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	MACROPORE INC
		DATE OF NAME CHANGE:	20010320
</SEC-HEADER>
<DOCUMENT>
<TYPE>RW
<SEQUENCE>1
<FILENAME>ef20046469_rw.htm
<DESCRIPTION>RW
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    <div style="text-align: center; font-weight: bold;">PLUS THERAPEUTICS, INC.</div>
    <div style="text-align: center; font-weight: bold;">2710 Reed Road, Suite 160</div>
    <div style="text-align: center; font-weight: bold;">Houston, Texas 77051</div>
    <div> <br>
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    <div>March 31, 2025</div>
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    <div>VIA EDGAR</div>
    <div> <br>
    </div>
    <div>U.S. Securities and Exchange Commission</div>
    <div>100 F Street, N.E.</div>
    <div>Washington, DC 20549</div>
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          <td style="width: 36pt; vertical-align: top; color: #000000;">Re:</td>
          <td style="width: auto; vertical-align: top;">
            <div style="color: #000000; font-weight: bold;">Plus Therapeutics, Inc.</div>
          </td>
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    <div style="margin-left: 36pt; color: #000000; font-weight: bold;">Registration Statement on Form S-1 (File No. 333-275712)</div>
    <div style="margin-left: 36pt; color: #000000; font-weight: bold;">Request for Withdrawal of Registration Statement</div>
    <div> <br>
    </div>
    <div>Ladies and Gentlemen:</div>
    <div> <br>
    </div>
    <div style="text-align: justify;">Reference is made to the Registration Statement on Form S-1 (File No. 333-275712) initially filed with the Securities and Exchange Commission (the &#8220;<font style="font-weight: bold;">Commission</font>&#8221;) by Plus Therapeutics, Inc. (the &#8220;<font style="font-weight: bold;">Company</font>&#8221;) on November 22,
      2023, as amended on March 8, 2024, together with all exhibits thereto (the &#8220;<font style="font-weight: bold;">Registration Statement</font>&#8221;). Pursuant to Rule 477(a) promulgated under the Securities
      Act of 1933, as amended (the &#8220;<font style="font-weight: bold;">Securities Act</font>&#8221;), the Company hereby respectfully requests that the Commission consent to the withdrawal of the Registration
      Statement, effective immediately.</div>
    <div style="text-align: justify;"> <br>
    </div>
    <div style="text-align: justify;">The Company has determined not to pursue, at this time, the contemplated public offering to which the Registration Statement relates. The Company confirms that no
      securities have been sold pursuant to the Registration Statement.</div>
    <div style="text-align: justify;"> <br>
    </div>
    <div style="text-align: justify;">The Company requests in accordance with Rule 457(p) under the Securities Act that all fees paid to the Commission in connection with the filing of the Registration
      Statement be credited to the Company&#8217;s account to be offset against the filing fee for any future registration statement the Company may file with the Commission.</div>
    <div style="text-align: justify;"> <br>
    </div>
    <div style="text-align: justify;">Upon the granting of the Commission&#8217;s consent, please send copies of the order withdrawing the Registration Statement to the undersigned, and to the Company&#8217;s legal
      counsel, Hogan Lovells US LLP, Attn: William Intner.</div>
    <div style="text-align: justify;"> <br>
    </div>
    <div style="text-align: justify;">Thank you for your attention to this matter. If you have any questions or require additional information, please do not hesitate to contact William Intner of Hogan
      Lovells US LLP at (410) 659-2778.</div>
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          <td style="width: 50%; vertical-align: bottom;">
            <div style="color: #000000;">Sincerely,</div>
          </td>
          <td style="width: 50%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 50%; vertical-align: bottom;">&#160;</td>
          <td style="width: 50%; vertical-align: bottom;">&#160;</td>
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          <td style="width: 50%; vertical-align: bottom; border-bottom: #000000 2px solid;">
            <div style="color: #000000;">/s/ Marc H. Hedrick, M.D.</div>
          </td>
          <td style="width: 50%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: bottom;">
            <div style="color: #000000;">Marc H. Hedrick, MD</div>
          </td>
          <td style="width: 50%; vertical-align: bottom;">&#160;</td>
        </tr>
        <tr>
          <td style="width: 50%; vertical-align: bottom;">
            <div style="color: #000000;">President &amp; Chief Executive Officer</div>
          </td>
          <td style="width: 50%; vertical-align: bottom;">&#160;</td>
        </tr>

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