    <SEC-DOCUMENT>0001140361-25-011649-index.html : 20250401
    <SEC-HEADER>0001140361-25-011649.hdr.sgml : 20250401
    <ACCEPTANCE-DATETIME>20250401173018
    ACCESSION NUMBER:		0001140361-25-011649
    CONFORMED SUBMISSION TYPE:	PRER14A
    PUBLIC DOCUMENT COUNT:		7
    FILED AS OF DATE:		20250401
    DATE AS OF CHANGE:		20250401

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			PLUS THERAPEUTICS, INC.
    		CENTRAL INDEX KEY:			0001095981
    		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
    		ORGANIZATION NAME:           	08 Industrial Applications and Services
    		EIN:				330827593
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		PRER14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-34375
    		FILM NUMBER:		25801093

    	BUSINESS ADDRESS:
    		STREET 1:		4200 MARATHON BLVD.
    		STREET 2:		SUITE 200
    		CITY:			AUSTIN
    		STATE:			TX
    		ZIP:			78756
    		BUSINESS PHONE:		737.255.7194

    	MAIL ADDRESS:
    		STREET 1:		4200 MARATHON BLVD.
    		STREET 2:		SUITE 200
    		CITY:			AUSTIN
    		STATE:			TX
    		ZIP:			78756

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	CYTORI THERAPEUTICS, INC.
    		DATE OF NAME CHANGE:	20050712

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	MACROPORE INC
    		DATE OF NAME CHANGE:	20010320
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>PRER14A
    <SEQUENCE>1
    <FILENAME>ny20044910x2_prer14a.htm
    <TEXT>
    Document 1 - file: ny20044910x2_prer14a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>logo_plustherapeutics1.jpg
    <TEXT>
    Document 2 - file: logo_plustherapeutics1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>ny20044910x2_internet.jpg
    <TEXT>
    Document 3 - file: ny20044910x2_internet.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>ny20044910x2_mail.jpg
    <TEXT>
    Document 4 - file: ny20044910x2_mail.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>ny20044910x2_pc01.jpg
    <TEXT>
    Document 5 - file: ny20044910x2_pc01.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>ny20044910x2_pc02.jpg
    <TEXT>
    Document 6 - file: ny20044910x2_pc02.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>ny20044910x2_phone.jpg
    <TEXT>
    Document 7 - file: ny20044910x2_phone.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>