    <SEC-DOCUMENT>0001140361-25-025650-index.html : 20250711
    <SEC-HEADER>0001140361-25-025650.hdr.sgml : 20250711
    <ACCEPTANCE-DATETIME>20250711160644
    ACCESSION NUMBER:		0001140361-25-025650
    CONFORMED SUBMISSION TYPE:	PRE 14A
    PUBLIC DOCUMENT COUNT:		25
    CONFORMED PERIOD OF REPORT:	20250807
    FILED AS OF DATE:		20250711
    DATE AS OF CHANGE:		20250711

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			PLUS THERAPEUTICS, INC.
    		CENTRAL INDEX KEY:			0001095981
    		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
    		ORGANIZATION NAME:           	08 Industrial Applications and Services
    		EIN:				330827593
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		PRE 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-34375
    		FILM NUMBER:		251119077

    	BUSINESS ADDRESS:
    		STREET 1:		4200 MARATHON BLVD.
    		STREET 2:		SUITE 200
    		CITY:			AUSTIN
    		STATE:			TX
    		ZIP:			78756
    		BUSINESS PHONE:		737.255.7194

    	MAIL ADDRESS:
    		STREET 1:		4200 MARATHON BLVD.
    		STREET 2:		SUITE 200
    		CITY:			AUSTIN
    		STATE:			TX
    		ZIP:			78756

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	CYTORI THERAPEUTICS, INC.
    		DATE OF NAME CHANGE:	20050712

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	MACROPORE INC
    		DATE OF NAME CHANGE:	20010320
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>PRE 14A
    <SEQUENCE>1
    <FILENAME>ny20044912x1_pre14a.htm
    <DESCRIPTION>PRE 14A
    <TEXT>
    Document 1 - file: ny20044912x1_pre14a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.LAB
    <SEQUENCE>2
    <FILENAME>pstv-20250807_lab.xml
    <DESCRIPTION>INLINE XBRL TAXONOMY EXTENSION - LABEL LINKBASE
    <TEXT>
    Document 2 - file: pstv-20250807_lab.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-101.SCH
    <SEQUENCE>3
    <FILENAME>pstv-20250807.xsd
    <DESCRIPTION>INLINE XBRL TAXONOMY EXTENSION - SCHEMA
    <TEXT>
    Document 3 - file: pstv-20250807.xsd

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>logo_plustherapeutics.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: logo_plustherapeutics.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>logo_plustherapeuticsx1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: logo_plustherapeuticsx1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>ny20044912x1_chair.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: ny20044912x1_chair.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>ny20044912x1_expert.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: ny20044912x1_expert.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>ny20044912x1_member.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 8 - file: ny20044912x1_member.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>ny20044912x1_pc01.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 9 - file: ny20044912x1_pc01.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>ny20044912x1_pc02.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 10 - file: ny20044912x1_pc02.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>ny20044912x1_pvpchart01x1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 11 - file: ny20044912x1_pvpchart01x1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>ny20044912x1_pvpchart02x1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 12 - file: ny20044912x1_pvpchart02x1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>sig_marchedrick.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 13 - file: sig_marchedrick.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>sig_marchedrickx1.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 14 - file: sig_marchedrickx1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>16
    <FILENAME>R1.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 16 - file: R1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>17
    <FILENAME>R2.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 17 - file: R2.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>18
    <FILENAME>R3.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 18 - file: R3.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>19
    <FILENAME>R4.htm
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 19 - file: R4.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>20
    <FILENAME>Show.js
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 20 - file: Show.js

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>21
    <FILENAME>report.css
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 21 - file: report.css

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>23
    <FILENAME>FilingSummary.xml
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 23 - file: FilingSummary.html

    Document 23 - RAW XML: FilingSummary.xml

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>JSON
    <SEQUENCE>25
    <FILENAME>MetaLinks.json
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 25 - file: MetaLinks.json

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>ZIP
    <SEQUENCE>26
    <FILENAME>0001140361-25-025650-xbrl.zip
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 26 - file: 0001140361-25-025650-xbrl.zip

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>XML
    <SEQUENCE>27
    <FILENAME>ny20044912x1_pre14a_htm.xml
    <DESCRIPTION>IDEA: XBRL DOCUMENT
    <TEXT>
    Document 27 - file: ny20044912x1_pre14a_htm.html

    Document 27 - RAW XML: ny20044912x1_pre14a_htm.xml

    </DOCUMENT>
    </SEC-DOCUMENT>