<SEC-DOCUMENT>0000930413-16-005714.txt : 20160226
<SEC-HEADER>0000930413-16-005714.hdr.sgml : 20160226
<ACCEPTANCE-DATETIME>20160226171932
ACCESSION NUMBER:		0000930413-16-005714
CONFORMED SUBMISSION TYPE:	SC 13D
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20160226
DATE AS OF CHANGE:		20160226

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BOVIE MEDICAL Corp
		CENTRAL INDEX KEY:			0000719135
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				112644611
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-35626
		FILM NUMBER:		161463396

	BUSINESS ADDRESS:	
		STREET 1:		4 MANHATTANVILLE ROAD, SUITE 106
		CITY:			PURCHASE
		STATE:			NY
		ZIP:			10577
		BUSINESS PHONE:		800-537-2790

	MAIL ADDRESS:	
		STREET 1:		4 MANHATTANVILLE ROAD, SUITE 106
		CITY:			PURCHASE
		STATE:			NY
		ZIP:			10577

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BOVIE MEDICAL CORP
		DATE OF NAME CHANGE:	19990216

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AN CON GENETICS INC
		DATE OF NAME CHANGE:	19920703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GREAT POINT PARTNERS LLC
		CENTRAL INDEX KEY:			0001281446
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D

	BUSINESS ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203 971-3300

	MAIL ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D
<SEQUENCE>1
<FILENAME>c84112_sc13d.htm
<TEXT>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-family: Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="width: 25%">&nbsp;</TD>
    <TD STYLE="width: 75%; font-family: Times New Roman, Times, Serif">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES<BR>
        SECURITIES AND EXCHANGE COMMISSION<BR>
        Washington, D.C. 20549</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Schedule 13D</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD>&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>Under the Securities Exchange Act of 1934</B></FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif"><B>(Amendment No. _____________)*</B></FONT></TD></TR>
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<DIV STYLE="float: right; width: 20%">


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    <TD NOWRAP STYLE="width: 100%; font-family: Times New Roman, Times, Serif; border: Black 1px solid; padding: 3pt 3pt 3pt 5pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>OMB APPROVAL</B></P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">OMB Number: 3235-0145</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">Expires: February 28, 2009</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">Estimated average burden<BR>
        hours per response......14.5</P>

</TD></TR>
</TABLE>
</DIV>
<P STYLE="font: 10pt Arial, Helvetica, Sans-Serif; margin: 0pt 0; text-align: justify; text-indent: 18pt"><BR CLEAR="ALL">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">Bovie Medical Corporation</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">Common Stock</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Title of Class of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">10211F100</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Ron Panzier</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Great Point Partners, LLC</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>165 Mason Street, 3<SUP>rd</SUP> Floor</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Greenwich, CT 06830</B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">(203) 971-3300</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, Address and Telephone Number of Person Authorized
to</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Receive Notices and Communications)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">February 24, 2016</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Date of Event which Requires Filing of this Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">If the filing person has previously filed a statement
on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because of &sect;&sect;240.13d-1(e),
240.13d-1(f) or 240.13d-1(g), check the following box. &nbsp;&nbsp;<FONT STYLE="font-family: Wingdings ">x</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><B>Note</B>: Schedule filed in paper format shall
include a signed original and five copies of the schedule, including all exhibits. See &sect;240.13d-7 for other parties to whom
copies are to be sent.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">*The remainder of this cover
page shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">The information required in the
remainder of this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange
Act of 1934 (&ldquo;Act&rdquo;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all
other provisions of the Act (however, see the Notes).</P>

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    <TD STYLE="padding-right: 6pt; width: 3%; font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; width: 86%; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD></TR>
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    <TD STYLE="border-top: Black 3px double; border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; font: 8pt Times New Roman, Times, Serif; text-align: center"><P STYLE="margin-top: 0; margin-bottom: 0; font-size: 8pt">&nbsp;</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt">1</FONT></P></TD>
    <TD STYLE="border-top: Black 3px double; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif"></TD>
    <TD COLSPAN="2" STYLE="border-top: Black 3px double; border-right: Black 3px double; border-bottom: black 1px solid; padding-right: 6pt; font-size: 8pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<BR>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Great Point Partners, LLC</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">37-1475292</P>

</TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD ROWSPAN="3" STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 3pt"><FONT STYLE="font-size: 10pt">2</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 3pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 3px double; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check the Appropriate Box if a Member of a Group<SUP> </SUP>(See Instructions)</FONT></TD></TR>
<TR STYLE="font-family: Times New Roman, Times, Serif">
    <TD STYLE="vertical-align: top; padding: 2pt 6pt; text-align: right; font-family: Times New Roman, Times, Serif"></TD>
    <TD STYLE="vertical-align: top; padding-right: 6pt; text-align: left; font-family: Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT></TD>
    <TD STYLE="border-right: Black 3px double; padding: 2pt 6pt; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings ">o</FONT></TD></TR>
<TR STYLE="font-family: Times New Roman, Times, Serif">
    <TD STYLE="vertical-align: top; padding: 2pt 6pt; text-align: right; font-family: Times New Roman, Times, Serif"></TD>
    <TD STYLE="vertical-align: top; padding-right: 6pt; text-align: left; font-family: Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT></TD>
    <TD STYLE="border-right: Black 3px double; padding: 2pt 6pt; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings ">o</FONT></TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">3</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"></TD>
    <TD COLSPAN="2" STYLE="border-top: black 1px solid; border-right: Black 3px double; border-bottom: black 1px solid; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">SEC Use Only</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">4</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 3px double; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Source of Funds (See Instructions)&nbsp;&nbsp;AF</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">5</FONT></TD>
    <TD STYLE="border-top: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"></TD>
    <TD COLSPAN="2" STYLE="border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) </FONT><FONT STYLE="font-family: Wingdings ">o</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-right: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">6</FONT></TD>
    <TD STYLE="border-top: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"></TD>
    <TD COLSPAN="2" STYLE="border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Citizenship or Place of Organization&nbsp;&nbsp;Delaware</FONT></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="width: 25%; border-top: black 1px solid; border-right: black 1px solid; border-left: Black 3px double; padding-top: 5pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Tahoma,sans-serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Number of Shares</FONT><P STYLE="font: 5pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Beneficially Owned by</FONT><P STYLE="font: 5pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Each Reporting Person With</FONT></TD>
    <TD STYLE="width: 5%; border-top: black 1px solid; border-right: black 1px solid; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">7</FONT></TD>
    <TD STYLE="width: 70%; border-top: Black 1px solid; border-right: Black 3px double; padding-right: 6pt; padding-left: 8pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole Voting Power&nbsp;&nbsp;-0-</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt; border-top: Black 1px solid"><FONT STYLE="font-size: 10pt">8</FONT></TD>
    <TD STYLE="border-top: Black 1px solid; border-right: Black 3px double; padding-right: 6pt; padding-left: 8pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Voting Power&nbsp;&nbsp;2,719,266<SUP>1</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">9</FONT></TD>
    <TD STYLE="border-top: Black 1px solid; border-right: Black 3px double; padding-right: 6pt; padding-left: 8pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;-0-</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">10</FONT></TD>
    <TD STYLE="border-top: Black 1px solid; border-right: Black 3px double; font: 12pt Tahoma,sans-serif; padding-right: 6pt; padding-left: 8pt; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Dispositive Power&nbsp;&nbsp;2,719,266</FONT><FONT STYLE="font: 8pt Times New Roman, Times, Serif"><SUP>1</SUP></FONT></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">11</FONT></TD>
    <TD STYLE="border-top: black 1px solid; font: 12pt Tahoma,sans-serif; padding-right: 6pt; padding-left: 6pt; padding-top: 5pt"></TD>
    <TD COLSPAN="5" STYLE="border-top: black 1px solid; border-right: Black 3px double; font: 12pt Tahoma,sans-serif; padding-right: 6pt; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Aggregate Amount Beneficially Owned by Each Reporting Person&nbsp;&nbsp;2,719,266</FONT><FONT STYLE="font: 8pt Times New Roman, Times, Serif"><SUP>1</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">12</FONT></TD>
    <TD STYLE="border-top: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"></TD>
    <TD COLSPAN="5" STYLE="border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions) </FONT><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">13</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"></TD>
    <TD COLSPAN="5" STYLE="border-top: black 1px solid; border-right: Black 3px double; border-bottom: black 1px solid; padding-right: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Percent of Class Represented by Amount in Row (11)&nbsp;&nbsp;9.985%<SUP>1,2</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">14</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"></FONT></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1px solid; padding-right: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 40pt">IA</P>

</TD>
    <TD STYLE="border-right: Black 3px double; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif"></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1px solid; padding-right: 6pt; font-family: Tahoma,sans-serif">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; border-right: Black 3px double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif"></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1px solid; padding-right: 6pt; font-family: Tahoma,sans-serif">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; border-right: Black 3px double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: Black 3px double; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; width: 10%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 1%; border-bottom: Black 3px double"><FONT STYLE="font-size: 1px"></FONT></TD>
    <TD STYLE="border-bottom: Black 3px double; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 5%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 3px double; padding-right: 6pt; padding-left: 6pt; width: 14%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 3px double; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 6%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 3px double; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 61%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 3%; border-right: Black 3px double; border-bottom: Black 3px double"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD></TR>
</TABLE>
<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0pt">&nbsp;</P>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0pt"><FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT><FONT STYLE="font-size: 8pt">
Consists of (i) 2,680,000 shares of Common Stock owned collectively by Biomedical Value Fund, LP (&ldquo;BMVF&rdquo;), Biomedical
Offshore Value Fund, Ltd. (&ldquo;BOVF&rdquo;), Biomedical Institutional Value Fund, LP (&ldquo;BIVF&rdquo;), Class D Series of
GEF-PS, LP (&ldquo;GEF-PS&rdquo;) and WS Investments II, LLC (&ldquo;WS&rdquo;), and (ii) 39,266 shares issuable upon conversion
of Series A 6% preferred stock collectively owned by each of BMVF, BOVF, BIVF, GEF-PS, and WS. Does not include: (i) Series A 6%
preferred stock convertible into 3,912,012 shares, collectively owned by each of BMVF, BOVF, BIVF, GEF-PS, and WS. The provisions
of such preferred stock restrict the conversion of such preferred stock to the extent that, after giving effect to such conversion,
the holder of the preferred stock and its affiliates and any other person or entities with which such holder would constitute
a group would beneficially own in excess of 9.985% of the number of shares of Common Stock of the Issuer outstanding immediately
after giving effect to such conversion or exercise (the &ldquo;Ownership Cap&rdquo;). Therefore, the reporting persons could be
deemed to beneficially own such number of shares underlying such preferred stock as would result in total beneficial ownership
by such reporting persons up to the Ownership Cap.</FONT></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0pt"><FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT><FONT STYLE="font-size: 8pt">
Based on a total of 27,194,251 shares outstanding, as reported by the Issuer on a Form 10-Q filed with the SEC on November 5,
2015.</FONT></P>

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    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 10%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; width: 1%"></TD>
    <TD STYLE="padding-right: 6pt; width: 3%; font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; width: 86%; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-top: Black 3px double; border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; font: 8pt Times New Roman, Times, Serif; text-align: center"><P STYLE="margin-top: 0; margin-bottom: 0; font-size: 8pt">&nbsp;</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt">1</FONT></P></TD>
    <TD STYLE="border-top: Black 3px double; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif"></TD>
    <TD COLSPAN="2" STYLE="border-top: Black 3px double; border-right: Black 3px double; border-bottom: black 1px solid; padding-right: 6pt; font-size: 8pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<BR>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Dr. Jeffrey R. Jay, M.D.</P>

</TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD ROWSPAN="3" STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 3pt"><FONT STYLE="font-size: 10pt">2</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 3pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 3px double; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check the Appropriate Box if a Member of a Group<SUP> </SUP>(See Instructions)</FONT></TD></TR>
<TR STYLE="font-family: Times New Roman, Times, Serif">
    <TD STYLE="vertical-align: top; padding: 2pt 6pt; text-align: right; font-family: Times New Roman, Times, Serif"></TD>
    <TD STYLE="vertical-align: top; padding-right: 6pt; text-align: left; font-family: Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT></TD>
    <TD STYLE="border-right: Black 3px double; padding: 2pt 6pt; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings ">o</FONT></TD></TR>
<TR STYLE="font-family: Times New Roman, Times, Serif">
    <TD STYLE="vertical-align: top; padding: 2pt 6pt; text-align: right; font-family: Times New Roman, Times, Serif"></TD>
    <TD STYLE="vertical-align: top; padding-right: 6pt; text-align: left; font-family: Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT></TD>
    <TD STYLE="border-right: Black 3px double; padding: 2pt 6pt; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings ">o</FONT></TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">3</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"></TD>
    <TD COLSPAN="2" STYLE="border-top: black 1px solid; border-right: Black 3px double; border-bottom: black 1px solid; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">SEC Use Only</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">4</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 3px double; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Source of Funds (See Instructions)&nbsp;&nbsp;AF</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">5</FONT></TD>
    <TD STYLE="border-top: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"></TD>
    <TD COLSPAN="2" STYLE="border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) </FONT><FONT STYLE="font-family: Wingdings ">o</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-right: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">6</FONT></TD>
    <TD STYLE="border-top: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"></TD>
    <TD COLSPAN="2" STYLE="border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Citizenship or Place of Organization  United States</FONT></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="width: 25%; border-top: black 1px solid; border-right: black 1px solid; border-left: Black 3px double; padding-top: 5pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Tahoma,sans-serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Number of Shares</FONT><P STYLE="font: 5pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Beneficially Owned by</FONT><P STYLE="font: 5pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Each Reporting Person With</FONT></TD>
    <TD STYLE="width: 5%; border-top: black 1px solid; border-right: black 1px solid; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">7</FONT></TD>
    <TD STYLE="width: 70%; border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; padding-left: 8pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole Voting Power&nbsp;&nbsp;-0-</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt; border-top: Black 1px solid"><FONT STYLE="font-size: 10pt">8</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; padding-left: 8pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Voting Power&nbsp;&nbsp;2,719,266<SUP>1</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">9</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; padding-left: 8pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;-0-</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">10</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-right: Black 3px double; font: 12pt Tahoma,sans-serif; padding-right: 6pt; padding-left: 8pt; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Dispositive Power&nbsp;&nbsp;2,719,266</FONT><FONT STYLE="font: 8pt Times New Roman, Times, Serif"><SUP>1</SUP></FONT></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">11</FONT></TD>
    <TD STYLE="border-top: black 1px solid; font: 12pt Tahoma,sans-serif; padding-right: 6pt; padding-left: 6pt; padding-top: 5pt"></TD>
    <TD COLSPAN="5" STYLE="border-top: black 1px solid; border-right: Black 3px double; font: 12pt Tahoma,sans-serif; padding-right: 6pt; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Aggregate Amount Beneficially Owned by Each Reporting Person&nbsp;&nbsp;2,719,266</FONT><FONT STYLE="font: 8pt Times New Roman, Times, Serif"><SUP>1</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">12</FONT></TD>
    <TD STYLE="border-top: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"></TD>
    <TD COLSPAN="5" STYLE="border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions) </FONT><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">13</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"></TD>
    <TD COLSPAN="5" STYLE="border-top: black 1px solid; border-right: Black 3px double; border-bottom: black 1px solid; padding-right: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Percent of Class Represented by Amount in Row (11)&nbsp;&nbsp;9.985%<SUP>1,2</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">14</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"></FONT></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1px solid; padding-right: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 40pt">IN</P>

</TD>
    <TD STYLE="border-right: Black 3px double; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif"></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1px solid; padding-right: 6pt; font-family: Tahoma,sans-serif">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; border-right: Black 3px double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif"></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1px solid; padding-right: 6pt; font-family: Tahoma,sans-serif">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; border-right: Black 3px double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: Black 3px double; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; width: 10%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 1%; border-bottom: Black 3px double"><FONT STYLE="font-size: 1px"></FONT></TD>
    <TD STYLE="border-bottom: Black 3px double; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 5%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 3px double; padding-right: 6pt; padding-left: 6pt; width: 14%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 3px double; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 6%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 3px double; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 61%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 3%; border-right: Black 3px double; border-bottom: Black 3px double"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD></TR>
</TABLE>

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<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding-right: 6pt; padding-left: 6pt; text-align: center; width: 10%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; width: 1%"></TD>
    <TD STYLE="padding-right: 6pt; width: 3%; font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; width: 86%; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-top: Black 3px double; border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; font: 8pt Times New Roman, Times, Serif; text-align: center"><P STYLE="margin-top: 0; margin-bottom: 0; font-size: 8pt">&nbsp;</P>
                                                                                <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 10pt">1</FONT></P></TD>
    <TD STYLE="border-top: Black 3px double; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif"></TD>
    <TD COLSPAN="2" STYLE="border-top: Black 3px double; border-right: Black 3px double; border-bottom: black 1px solid; padding-right: 6pt; font-size: 8pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<BR>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Mr. David Kroin</P>

</TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD ROWSPAN="3" STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 3pt"><FONT STYLE="font-size: 10pt">2</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 3pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 3px double; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 3pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check the Appropriate Box if a Member of a Group<SUP> </SUP>(See Instructions)</FONT></TD></TR>
<TR STYLE="font-family: Times New Roman, Times, Serif">
    <TD STYLE="vertical-align: top; padding: 2pt 6pt; text-align: right; font-family: Times New Roman, Times, Serif"></TD>
    <TD STYLE="vertical-align: top; padding-right: 6pt; text-align: left; font-family: Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT></TD>
    <TD STYLE="border-right: Black 3px double; padding: 2pt 6pt; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings ">o</FONT></TD></TR>
<TR STYLE="font-family: Times New Roman, Times, Serif">
    <TD STYLE="vertical-align: top; padding: 2pt 6pt; text-align: right; font-family: Times New Roman, Times, Serif"></TD>
    <TD STYLE="vertical-align: top; padding-right: 6pt; text-align: left; font-family: Times New Roman, Times, Serif; padding-top: 2pt; padding-bottom: 2pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT></TD>
    <TD STYLE="border-right: Black 3px double; padding: 2pt 6pt; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings ">o</FONT></TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">3</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"></TD>
    <TD COLSPAN="2" STYLE="border-top: black 1px solid; border-right: Black 3px double; border-bottom: black 1px solid; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">SEC Use Only</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">4</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 3px double; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Source of Funds (See Instructions)&nbsp;&nbsp;AF</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">5</FONT></TD>
    <TD STYLE="border-top: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"></TD>
    <TD COLSPAN="2" STYLE="border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) </FONT><FONT STYLE="font-family: Wingdings ">o</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="border-right: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">6</FONT></TD>
    <TD STYLE="border-top: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"></TD>
    <TD COLSPAN="2" STYLE="border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Citizenship or Place of Organization  United States</FONT></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="width: 25%; border-top: black 1px solid; border-right: black 1px solid; border-left: Black 3px double; padding-top: 5pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Tahoma,sans-serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Number of Shares</FONT><P STYLE="font: 5pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Beneficially Owned by</FONT><P STYLE="font: 5pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Each Reporting Person With</FONT></TD>
    <TD STYLE="width: 5%; border-top: black 1px solid; border-right: black 1px solid; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">7</FONT></TD>
    <TD STYLE="width: 70%; border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; padding-left: 8pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole Voting Power&nbsp;&nbsp;-0-</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt; border-top: Black 1px solid"><FONT STYLE="font-size: 10pt">8</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; padding-left: 8pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Voting Power&nbsp;&nbsp;2,719,266<SUP>1</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">9</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; padding-left: 8pt; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">Sole Dispositive Power&nbsp;&nbsp;-0-</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">10</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-right: Black 3px double; font: 12pt Tahoma,sans-serif; padding-right: 6pt; padding-left: 8pt; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Dispositive Power&nbsp;&nbsp;2,719,266</FONT><FONT STYLE="font: 8pt Times New Roman, Times, Serif"><SUP>1</SUP></FONT></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">11</FONT></TD>
    <TD STYLE="border-top: black 1px solid; font: 12pt Tahoma,sans-serif; padding-right: 6pt; padding-left: 6pt; padding-top: 5pt"></TD>
    <TD COLSPAN="5" STYLE="border-top: black 1px solid; border-right: Black 3px double; font: 12pt Tahoma,sans-serif; padding-right: 6pt; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Aggregate Amount Beneficially Owned by Each Reporting Person&nbsp;&nbsp;2,719,266</FONT><FONT STYLE="font: 8pt Times New Roman, Times, Serif"><SUP>1</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">12</FONT></TD>
    <TD STYLE="border-top: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"></TD>
    <TD COLSPAN="5" STYLE="border-top: black 1px solid; border-right: Black 3px double; padding-right: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
Instructions) </FONT><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">13</FONT></TD>
    <TD STYLE="border-top: black 1px solid; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"></TD>
    <TD COLSPAN="5" STYLE="border-top: black 1px solid; border-right: Black 3px double; border-bottom: black 1px solid; padding-right: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Percent of Class Represented by Amount in Row (11)&nbsp;&nbsp;9.985%<SUP>1,2</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; padding-top: 5pt"><FONT STYLE="font-size: 10pt">14</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif"></FONT></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1px solid; padding-right: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 40pt">IN</P>

</TD>
    <TD STYLE="border-right: Black 3px double; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; padding-top: 5pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif"></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1px solid; padding-right: 6pt; font-family: Tahoma,sans-serif">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; border-right: Black 3px double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif"></TD>
    <TD COLSPAN="4" STYLE="border-bottom: black 1px solid; padding-right: 6pt; font-family: Tahoma,sans-serif">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; border-right: Black 3px double">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: Black 3px double; border-left: Black 3px double; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; width: 10%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 1%; border-bottom: Black 3px double"><FONT STYLE="font-size: 1px"></FONT></TD>
    <TD STYLE="border-bottom: Black 3px double; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 5%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 3px double; padding-right: 6pt; padding-left: 6pt; width: 14%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 3px double; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 6%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="border-bottom: Black 3px double; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 61%"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; font-family: Tahoma,sans-serif; width: 3%; border-right: Black 3px double; border-bottom: Black 3px double"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD></TR>
</TABLE>

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    <DIV STYLE="margin-bottom: 6pt; border-bottom: Silver 4px solid"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 12pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
    <!-- Field: /Page -->

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 72pt; text-align: left">Item 1.</TD><TD STYLE="text-align: justify">Security and Issuer</TD>
</TR></TABLE>

<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt; text-indent: -72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">The title and class of equity
securities to which this statement relates is Common Stock, par value $.001 per share.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt; text-align: left; text-indent: 0pt">The name and address of
the principal executive offices of the issuer is</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt; text-align: left; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt; text-align: left; text-indent: 0pt">Bovie Medical Corporation</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt; text-align: left; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt; text-align: left; text-indent: 0pt">4 Manhattanville Road,
Suite 106, Purchase NY 10577<BR>
<BR>
</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt; text-align: left; text-indent: 0pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 72pt; text-align: left">Item 2.</TD><TD STYLE="text-align: justify">Identity and Background</TD>
</TR></TABLE>

<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt; text-indent: -72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">The identify and background
of the persons filing this statement is as follows:</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">Great Point Partners LLC (&ldquo;Great
Point&rdquo;) is a Delaware limited liability company, with its principal offices at 165 Mason Street, 3<SUP>rd</SUP> Floor, Greenwich,
CT 06830.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">Dr. Jeffrey R. Jay (&ldquo;Dr.
Jay&rdquo;) is an individual with a business address at 165 Mason Street, 3<SUP>rd</SUP> Floor, Greenwich, CT 06830. Dr. Jay is
a citizen of the United States and senior managing member of Great Point.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">Mr. David Kroin (&ldquo;Mr.
Kroin&rdquo;) is an individual with a business address at 165 Mason Street, 3<SUP>rd</SUP> Floor, Greenwich, CT 06830. Mr. Kroin
is a citizen of the United States and special managing member of Great Point.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">None of the Reporting Persons
was during the last five years, convicted of a criminal proceeding (excluding traffic violations or similar misdemeanors).</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">None of the Reporting Persons
was during the last five years, a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and
as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting
or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 72pt; text-align: left">Item 3.</TD><TD STYLE="text-align: justify">Source and Amount of Funds or Other Consideration</TD>
</TR></TABLE>

<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt; text-indent: -72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">Biomedical Value Fund, L.P.
(&ldquo;BMVF&rdquo;) used its own funds to purchase 1,270,255 shares of Common Stock (&ldquo;BMVF Shares&rdquo;) and Series A 6%
preferred stock convertible into 1,866,735 shares of Common Stock (the &ldquo;BMVF Preferred Shares&rdquo;).</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">Biomedical Offshore Value Fund,
Ltd. (&ldquo;BOVF&rdquo;) used its own funds to purchase 710,610 shares of Common Stock (the &ldquo;BOVF Shares&rdquo;) and Series
A 6% preferred stock convertible into 1,044,295 shares of Common Stock (the &ldquo;BOVF Preferred Shares&rdquo;.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">Biomedical Institutional Value
Fund, L.P. (&ldquo;BIVF&rdquo;) used its own funds to purchase 326,669 shares of Common Stock (the &ldquo;BIVF Shares&rdquo;) and
Series A 6% preferred stock convertible into 480,065 shares of Common Stock (the &ldquo;BIVF Preferred Shares&rdquo;).</P>

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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">Class D Series of GEF-PS, LP
(&ldquo;GEF-PS&rdquo;) used its own funds to purchase 336,206 shares of Common Stock (the &ldquo;GEF-PS Shares&rdquo;) and Series
A 6% preferred stock convertible into 489,669 shares of Common Stock (the &ldquo;GEF-PS Preferred Shares&rdquo;).</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">WS Investments II, LLC (&ldquo;WS&rdquo;)
used its own funds to purchase 39,260 shares of Common Stock (&ldquo;WS Shares&rdquo;) and Series A 6% preferred stock convertible
into 70,514 shares of Common Stock (the &ldquo;WS Preferred Shares&rdquo;).</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">The provisions of the preferred
stock described above restrict the conversion of such preferred stock to the extent that, after giving effect to such conversion,
the holder of the preferred stock and its affiliates and any other person or entities with which such holder would constitute a
group would beneficially own in excess of 9.985% of the number of shares of Common Stock of the Issuer outstanding immediately
after giving effect to such exercise (the &ldquo;Ownership Cap&rdquo;). Therefore, the reporting persons could be deemed to beneficially
own such number of shares underlying such preferred stock as would result in total beneficial ownership by such reporting persons
up to the Ownership Cap.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">See Item 5 below for information
with respect to Great Point, Dr. Jay and Mr. Kroin.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 72pt; text-align: left">Item 4.</TD><TD STYLE="text-align: justify">Purpose of Transaction</TD>
</TR></TABLE>

<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt; text-indent: -72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">The securities of
the Issuer were acquired for investment. Each of the Reporting Persons has, subsequent to the date of acquisition of the
securities, determined to seek to influence the board of directors of the Issuer to take more affirmative steps designed to
maximize shareholder value, including, if appropriate, seeking changes to the composition of the board of directors, and/or
encouraging the Issuer to evaluate strategic alternatives. None of the Reporting Persons has yet formulated any specific plan
to implement such new determination. See Item 6 below for additional information.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 72pt; text-align: left">Item 5.</TD><TD STYLE="text-align: justify">Interest in Securities of the Issuer</TD>
</TR></TABLE>

<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt; text-indent: -72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">BMVF beneficially owns in the
aggregate 1,270,255 BMVF Shares and 18,551 BMVF Preferred Shares. Such shares in the aggregate constitute 4.73% of the shares of
Common Stock outstanding, computed in accordance with Rule 13d-3. BMVF shares voting and dispositive power over the BMVF Shares
and BMVF Preferred Shares.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">BOVF beneficially owns in the
aggregate 710,610 BOVF Shares and 10,378 BOVF Preferred Shares. Such shares in the aggregate constitute 2.65% of the shares of
Common Stock outstanding, computed in accordance with Rule 13d-3. BOVF shares voting and dispositive power over the BOVF Shares
and BOVF Preferred Shares.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">BIVF beneficially owns in the
aggregate 326,660 BIVF Shares and 4,771 BIVF Preferred Shares. Such shares in the aggregate constitute 1.22% of the shares of Common
Stock outstanding, computed in accordance with Rule 13d-3. BIVF shares voting and dispositive power of the BIVF Shares and BIVF
Preferred Shares.</P>

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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">GEF-PS beneficially owns in
the aggregate 333,206 GEF-PS Shares and 4,866 GEF-PS Preferred Shares. Such shares in the aggregate constitute 1.24% of the shares
of Common Stock outstanding, computed in accordance with Rule 13d-3. GEF-PS shares voting and dispositive power of the GEF-PS Shares
and GEF-PS Preferred Shares.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">WS beneficially owns in the
aggregate 39,260 WS Shares and 701 WS Preferred Shares. Such shares in the aggregate constitute 0.15% of the shares of Common Stock
outstanding, computed in accordance with Rule 13d-3. WS shares voting and dispositive power of the WS Shares and WS Preferred Shares.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">The foreoing does not include:
(i) Series A 6% preferred stock convertible into 3,912,012 shares, collectively owned by each of BMVF, BOVF, BIVF, GEF-PS, and
WS. The provisions of such preferred stock restrict the conversion of such preferred stock to the extent that, after giving effect
to such conversion, the holder of the preferred stock and its affiliates and any other person or entities with which such holder
would constitute a group would beneficially own in excess of 9.985% of the number of shares of Common Stock of the Issuer outstanding
immediately after giving effect to such conversion or exercise (the &ldquo;Ownership Cap&rdquo;). Therefore, the reporting persons
could be deemed to beneficially own such number of shares underlying such preferred stock as would result in total beneficial ownership
by such reporting persons up to the Ownership Cap.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">Great Point is the investment
manager of each of BMVF, BIVF, BOVF, GEF-PS and WS and by virtue of such status may be deemed to be the beneficial owner of the
BMVF Shares, the BMVF Preferred shares, the BOVF Shares, the BOVF Preferred Shares, the BIVF Shares, the BIVF Preferred Shares,
the GEF-PS Shares, the GEF-PS Preferred Shares, the WS Shares and WS Preferred Shares. Each of Dr. Jay, as senior managing member
of Great Point, and Mr. Kroin, and special managing member of Great Point, has shared voting and investment power with respect
to the BMVF Shares, the BMVF Preferred shares, the BOVF Shares, the BOVF Preferred Shares, the BIVF Shares, the BIVF Preferred
Shares, the GEF-PS Shares, the GEF-PS Preferred Shares, the WS Shares and WS Preferred Shares and may be deemed to be the beneficial
owner of such shares. Great Point, Dr. Jay and Mr. Kroin disclaim beneficial ownership of the BMVF Shares, the BMVF Preferred shares,
the BOVF Shares, the BOVF Preferred Shares, the BIVF Shares, the BIVF Preferred Shares, the GEF-PS Shares, the GEF-PS Preferred
Shares, the WS Shares and WS Preferred Sharesexcept to the extent of any pecuniary interest, and this statement shall not be deemed
to be an admission that they are the beneficial owners of such securities.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 72pt; text-align: left">Item 6.</TD><TD STYLE="text-align: justify">Contracts, Arrangements, Understandings or Relationships with Respect to Securities
of the Issuer</TD>
</TR></TABLE>

<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt; text-indent: -72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">Not applicable.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" STYLE="font: bold 12pt Times New Roman, Times, Serif; margin-top: 0; margin-bottom: 0pt; width: 100%"><TR STYLE="vertical-align: top; text-align: justify">
<TD STYLE="width: 72pt; text-align: left">Item 7.</TD><TD STYLE="text-align: justify">Material to be Filed as Exhibits</TD>
</TR></TABLE>

<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt; text-indent: -72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">The following documents are
filed as exhibits and are incorporated herein.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 72pt">EXHIBIT A: Joint Filing Agreement, dated as of February 26,
2016.</P>

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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><FONT STYLE="font-weight: normal"><I>Signature</I></FONT></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">After reasonable inquiry and
to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Date: February 26, 2016</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">Great
    Point Partners, LLC</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left; width: 50%"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left; width: 3%"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left; width: 37%"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left; width: 10%"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">By:</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left; border-bottom: Black 1px solid; padding-left: 20pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">/s/
    Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left; padding-left: 20pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">Name:&nbsp;&nbsp;Dr.
    Jeffrey R. Jay</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left; padding-left: 20pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">Title:&nbsp;&nbsp;Senior
    Managing Member</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left; padding-left: 20pt"><FONT STYLE="font-family: Times New Roman, Times, Serif">/s/ Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font: 1px Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left; border-bottom: Black 1px solid; padding-left: 38pt"></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font: 1px Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">Dr. Jeffrey R. Jay, individually</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left; padding-left: 20pt">/s/ Mr. David Kroin</TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font: 1px Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left; border-bottom: Black 1px solid; padding-left: 30pt"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font: 1px Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">Mr. David Kroin, individually</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
</TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>AGREEMENT REGARDING THE JOINT FILING OF SCHEDULE
13D</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">The undersigned hereby agree as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 12pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 36pt"></TD><TD STYLE="width: 36pt"><FONT STYLE="font-size: 10pt">(i)</FONT></TD><TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Each of them is individually eligible to use the Schedule 13D to which
this Exhibit is attached, and such Schedule 13D is filed on behalf of each of them; and</FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 12pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 12pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 36pt"></TD><TD STYLE="width: 36pt"><FONT STYLE="font-size: 10pt">(ii)</FONT></TD><TD STYLE="text-align: left"><FONT STYLE="font-size: 10pt">Each of them is responsible for the timely filing of such Schedule 13D
and any amendments thereto, and for the completeness and accuracy of the information concerning such person contained therein;
but none of them is responsible for the completeness or accuracy of the information concerning the other persons making the filing,
unless such person knows or has reason to believe that such information is inaccurate.</FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 12pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">Date:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;February 26, 2016</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Great Point Partners, LLC</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
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    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left; width: 50%"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left; width: 3%"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left; width: 37%"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left; width: 10%"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
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    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">By:</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left; border-bottom: Black 1px solid; padding-left: 20pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/
Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
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    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left; padding-left: 20pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Name:&nbsp;&nbsp;Dr.
    Jeffrey R. Jay</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
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    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left; padding-left: 20pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Title:&nbsp;&nbsp;Senior
    Managing Member</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
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    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
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    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left; padding-left: 20pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/
Dr. Jeffrey R. Jay</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
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    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font: 1px Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif; text-align: left; border-bottom: Black 1px solid"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font: 1px Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Dr. Jeffrey R. Jay, individually</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
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    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left">&nbsp;</TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left; padding-left: 20pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">/s/
Mr. David Kroin</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font: 1px Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif; text-align: left; border-bottom: Black 1px solid"><FONT STYLE="font-size: 1px">&nbsp;</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font: 1px Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top; font-family: Times New Roman, Times, Serif">
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD>
    <TD COLSPAN="2" STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Mr. David Kroin, individually</FONT></TD>
    <TD STYLE="font-family: Times New Roman, Times, Serif; text-align: left"><FONT STYLE="font-family: Times New Roman, Times, Serif">&nbsp;</FONT></TD></TR>
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