<SEC-DOCUMENT>0000930413-16-008801.txt : 20161123
<SEC-HEADER>0000930413-16-008801.hdr.sgml : 20161123
<ACCEPTANCE-DATETIME>20161122215455
ACCESSION NUMBER:		0000930413-16-008801
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20161123
DATE AS OF CHANGE:		20161122

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BOVIE MEDICAL Corp
		CENTRAL INDEX KEY:			0000719135
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				112644611
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-35626
		FILM NUMBER:		162014745

	BUSINESS ADDRESS:	
		STREET 1:		4 MANHATTANVILLE ROAD, SUITE 106
		CITY:			PURCHASE
		STATE:			NY
		ZIP:			10577
		BUSINESS PHONE:		800-537-2790

	MAIL ADDRESS:	
		STREET 1:		4 MANHATTANVILLE ROAD, SUITE 106
		CITY:			PURCHASE
		STATE:			NY
		ZIP:			10577

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BOVIE MEDICAL CORP
		DATE OF NAME CHANGE:	19990216

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AN CON GENETICS INC
		DATE OF NAME CHANGE:	19920703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GREAT POINT PARTNERS LLC
		CENTRAL INDEX KEY:			0001281446
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203 971-3300

	MAIL ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>c86644_sc13da.htm
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 20%; text-align: center">&nbsp;</td>
    <TD STYLE="width: 56%; text-align: center"><B>&nbsp; &nbsp; UNITED STATES</B></td>
    <TD STYLE="width: 4%; text-align: center">&nbsp;</td>
    <TD STYLE="width: 20%; text-align: center">&nbsp;</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD ROWSPAN="6" STYLE="text-align: center; vertical-align: middle; border: Black 1px solid"><FONT STYLE="font-size: 8pt"><B>OMB
    APPROVAL</B><br>
    <br>
    OMB Number: 3235-0145<br>
    Expires: February 28, 2009<br>
    Estimated average burden<br>
    hours per response&nbsp;&nbsp;&nbsp;&nbsp;14.5</FONT></td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center"><B>Washington, D.C. 20549</B></td>
    <TD STYLE="text-align: center">&nbsp;</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center">&nbsp;</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center"><B>Schedule 13D/A</B></td>
    <TD STYLE="text-align: center">&nbsp;</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center"><B>Under the Securities Exchange
    Act of </B> <B>1934</B></td>
    <TD STYLE="text-align: center">&nbsp;</td></tr>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</td>
    <TD STYLE="text-align: center"><B>(Amendment No. 1)*</B></td>
    <TD STYLE="text-align: center">&nbsp;</td></tr>
</table>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">Bovie Medical Corporation</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">Common Stock</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Title of Class of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">10211F100</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Ron Panzier</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Great Point Partners, LLC </B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>165 Mason Street, 3<SUP>rd</SUP> Floor</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Greenwich, CT 06830</B></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">(203) 971-3300</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name, Address and Telephone Number of
Person Authorized to</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Receive Notices and Communications)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">November 22, 2016</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Date of Event which Requires Filing of
this Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">If the filing person has previously filed
a statement on Schedule 13G to report the acquisition that is the subject of this Schedule 13D, and is filing this schedule because
of &sect;&sect;240.13d-1(e), 240.13d-1(f) or 240.13d-1(g), check the following box. <FONT STYLE="font-family: Wingdings ">x</FONT></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><B>Note</B>: Schedule filed in paper format
shall include a signed original and five copies of the schedule, including all exhibits. See &sect;240.13d-7 for other parties
to whom copies are to be sent.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">*The remainder of this
cover page shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover
page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">The information required
in the remainder of this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities
Exchange Act of 1934 (&ldquo;Act&rdquo;) or otherwise subject to the liabilities of that section of the Act but shall be subject
to all other provisions of the Act (however, see the Notes).</P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-top: Black 3px double; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: black 3px double; text-align: center; padding-right: 6pt; padding-left: 6pt; vertical-align: top; padding-top: 6pt">1</TD>
    <TD COLSPAN="7" STYLE="border-top: Black 3px double; border-right: Black 3px double; border-bottom: Black 1px solid; padding-right: 6pt; padding-left: 6pt; padding-top: 6pt"><P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">Names of Reporting Persons.<BR>
I.R.S. Identification Nos. of above persons (entities only).</P>

<P STYLE="font: 6pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">Great Point Partners, LLC</P>

<P STYLE="font: 6pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>
    37-1475292</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="border-right: Black 1px solid; border-left: Black 3px double; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">2</TD>
    <TD COLSPAN="7" STYLE="border-right: black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">Check
    the Appropriate Box if a Member of a Group<SUP> </SUP>(See Instructions)</TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">(a)</TD>
    <TD COLSPAN="5" STYLE="border-right: black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">(b)</TD>
    <TD COLSPAN="5" STYLE="border-right: Black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: black 3px double; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-top: Black 1px solid">3</TD>
    <TD COLSPAN="7" STYLE="border-top: Black 1px solid; border-right: black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">SEC
    Use Only</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-left: black 3px double; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">4</TD>
    <TD COLSPAN="7" STYLE="border-right: black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">Source
    of Funds (See Instructions) AF</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: black 3px double; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-top: Black 1px solid">5</TD>
    <TD COLSPAN="7" STYLE="border-top: Black 1px solid; border-right: black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">Check
    if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) <FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: black 3px double; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">6</TD>
    <TD COLSPAN="7" STYLE="border-bottom: Black 1px solid; border-right: black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">Citizenship
    or Place of Organization Delaware</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="4" ROWSPAN="4" STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 3px double; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; vertical-align: middle"><P STYLE="margin-top: 0pt; font: 10pt Times New Roman, Times, Serif; margin-bottom: 0pt">Number of Shares</P>

<P STYLE="margin-top: 0pt; font: 10pt Times New Roman, Times, Serif; margin-bottom: 0pt">Beneficially Owned by</P>

<P STYLE="margin-top: 0pt; font: 10pt Times New Roman, Times, Serif; margin-bottom: 0pt">Each Reporting Person With</P></TD>
    <TD STYLE="border-right: Black 1px solid; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; vertical-align: bottom">7</TD>
    <TD COLSPAN="3" STYLE="border-right: black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: left; vertical-align: bottom">Sole
    Voting Power -0-</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: Black 1px solid; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-top: Black 1px solid; vertical-align: bottom">8</TD>
    <TD COLSPAN="3" STYLE="border-top: Black 1px solid; border-right: black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: left; vertical-align: bottom">Shared
    Voting Power 3,046,272 <SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; vertical-align: bottom">9</TD>
    <TD COLSPAN="3" STYLE="border-right: Black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: left; vertical-align: bottom">Sole
    Dispositive Power -0-</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; vertical-align: bottom">10</TD>
    <TD COLSPAN="3" STYLE="border-right: Black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: left; vertical-align: bottom">Shared
    Dispositive Power 3,046,272 <SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-left: Black 3px double; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">11</TD>
    <TD COLSPAN="7" STYLE="border-right: black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">Aggregate
    Amount Beneficially Owned by Each Reporting Person 3,046,272 <SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; border-top: Black 1px solid">12</TD>
    <TD COLSPAN="7" STYLE="border-top: Black 1px solid; border-right: black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">Check
    if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: black 3px double; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">13</TD>
    <TD COLSPAN="7" STYLE="border-right: black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">Percent
    of Class Represented by Amount in Row (11) 9.985%<SUP>1,2</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-left: Black 3px double; text-align: center; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">14</TD>
    <TD COLSPAN="7" STYLE="border-right: Black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">Type
    of Reporting Person (See Instructions)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 3px double; border-left: Black 3px double; padding: 6pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="7" STYLE="border-right: Black 3px double; border-bottom: Black 3px double; padding: 6pt; text-align: left; vertical-align: bottom">

    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 36pt">IA</P>

        <DIV STYLE="font-size: 1pt; border-top: Black 1px solid; margin-right: 36pt">&nbsp;</DIV>

        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

        <DIV STYLE="font-size: 1pt; border-top: Black 1px solid; margin-right: 36pt">&nbsp;</DIV>

        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

        <DIV STYLE="font-size: 1pt; border-top: Black 1px solid; margin-right: 36pt">&nbsp;</DIV></TD></TR>
<TR STYLE="vertical-align: top; font-size: 1pt">
    <TD STYLE="text-align: center; padding-right: 6pt; padding-left: 6pt; width: 6%; font-size: 1pt">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; width: 2%; font-size: 1pt">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; width: 4%; font-size: 1pt">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; width: 10%; font-size: 1pt">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; width: 6%; font-size: 1pt; text-align: center; vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; width: 30%; font-size: 1pt">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; width: 34%; font-size: 1pt">&nbsp;</TD>
    <TD STYLE="padding-right: 6pt; padding-left: 6pt; width: 8%; font-size: 1pt">&nbsp;</TD></TR>
</TABLE>


<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><SUP>1</SUP> Consists of (i) 1,180,000
shares of Common Stock owned collectively by Biomedical Value Fund, LP (&ldquo;BVF&rdquo;), Biomedical Offshore Value Fund, Ltd.
(&ldquo;BOVF&rdquo;), Biomedical Institutional Value Fund, LP (&ldquo;BIVF&rdquo;), Class D Series of GEF-PS, LP (&ldquo;GEF-PS&rdquo;)
and WS Investments II, LLC (&ldquo;WS&rdquo;), and (ii) 1,866,272 shares issuable upon conversion of Series B Preferred Stock
collectively owned by each of BVF, BOVF, BIVF, GEF-PS, and WS. The foregoing does not include Series B Preferred Stock convertible
into 2,085,006 shares collectively owned by each of BVF, BOVF, BIVF, GEF-PS, and WS. The provisions of such preferred stock restrict
the conversion of such preferred stock to the extent that, after giving effect to such conversion, the holder of the preferred
stock and its affiliates and any other person or entities with which such holder would constitute a group would beneficially own
in excess of 9.985% of the number of shares of Common Stock of the Issuer outstanding immediately after giving effect to such
conversion (the &ldquo;Beneficial Ownership Cap&rdquo;). Therefore, the reporting persons could be deemed to beneficially own
such number of shares underlying such preferred stock as would result in total beneficial ownership by such reporting persons
up to the Beneficial Ownership Cap.</P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"><SUP>2</SUP> Based on a total of 28,642,218
shares outstanding, as reported by the Issuer in a Prospectus Supplement filed with the SEC on Nov. 10, 2016.</P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-top: Black 3px double; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; font: 12pt Times New Roman, Times, Serif; padding-right: 6pt; padding-left: 6pt; text-align: center; vertical-align: top; padding-top: 6pt"><FONT STYLE="font-size: 10pt">1</FONT></TD>
    <TD COLSPAN="2" STYLE="border-top: Black 3px double; border-right: Black 3px double; border-bottom: Black 1px solid; padding-right: 6pt; padding-left: 6pt; padding-top: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<BR>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Dr. Jeffrey R. Jay, M.D.</P>

</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-left: Black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">2</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma, Helvetica, Sans-Serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check the Appropriate Box if a Member of a Group<SUP> </SUP>(See Instructions)</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 5%; border-left: Black 3px double; border-right: Black 1px solid; padding-top: 3pt; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 5%; padding-top: 3pt; padding-bottom: 3pt; text-align: center; font-family: Tahoma, Helvetica, Sans-Serif; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(a)</FONT></TD>
    <TD STYLE="width: 90%; border-right: Black 3px double; padding-top: 3pt; padding-right: 6pt; padding-bottom: 3pt; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; border-right: Black 1px solid; border-left: Black 3px double; padding-top: 3pt; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-bottom: 3pt; text-align: center; font-family: Tahoma, Helvetica, Sans-Serif; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">(b)</FONT></TD>
    <TD STYLE="border-right: Black 3px double; padding-top: 3pt; padding-right: 6pt; padding-bottom: 3pt; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; border-top: Black 1px solid"><FONT STYLE="font-size: 10pt">3</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma, Helvetica, Sans-Serif; border-top: Black 1px solid"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">SEC Use Only</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-left: Black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">4</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma, Helvetica, Sans-Serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Source of Funds (See Instructions) AF</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-left: Black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">5</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma, Helvetica, Sans-Serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) </FONT><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-left: Black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">6</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: Black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma, Helvetica, Sans-Serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Citizenship or Place of Organization United States</FONT></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="width: 26%; border-top: Black 1px solid; border-right: Black 1px solid; border-left: Black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Tahoma, Helvetica, Sans-Serif; vertical-align: middle"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Number of Shares</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Beneficially Owned by</FONT><BR>
<FONT STYLE="font: 10pt Times New Roman, Times, Serif">Each Reporting Person With</FONT></TD>
    <TD STYLE="width: 6%; border-top: Black 1px solid; border-right: Black 1px solid; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; vertical-align: bottom"><FONT STYLE="font-size: 10pt">7</FONT></TD>
    <TD STYLE="width: 68%; border-top: Black 1px solid; border-right: Black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma, Helvetica, Sans-Serif; text-align: left; vertical-align: bottom"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Sole Voting Power -0-</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; vertical-align: bottom"><FONT STYLE="font-size: 10pt">8</FONT></TD>
    <TD STYLE="border-right: Black 3px double; border-bottom: Black 1px solid; font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: left; vertical-align: bottom"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Voting Power 3,046,272</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif"> <FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; vertical-align: bottom"><FONT STYLE="font-size: 10pt">9</FONT></TD>
    <TD STYLE="border-right: Black 3px double; border-bottom: Black 1px solid; padding-top: 3pt; padding-right: 6pt; padding-left: 6pt; font-family: Times New Roman, Times, Serif; text-align: left; vertical-align: bottom"><FONT STYLE="font-size: 10pt">Sole Dispositive Power -0-</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif; vertical-align: bottom"><FONT STYLE="font-size: 10pt">10</FONT></TD>
    <TD STYLE="border-right: Black 3px double; font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: left; vertical-align: bottom"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Shared Dispositive Power 3,046,272</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif"> <FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT></FONT></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 5%; border-top: Black 1px solid; border-right: Black 1px solid; border-bottom: Black 1px solid; border-left: Black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">11</FONT></TD>
    <TD STYLE="width: 95%; border-top: Black 1px solid; border-right: Black 3px double; border-bottom: Black 1px solid; font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Aggregate Amount Beneficially Owned by Each Reporting Person 3,046,272</FONT><FONT STYLE="font-family: Times New Roman, Times, Serif"> <FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-left: Black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">12</FONT></TD>
    <TD STYLE="border-right: Black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; font-family: Tahoma, Helvetica, Sans-Serif"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions) </FONT><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-left: Black 3px double; border-bottom: Black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; text-align: center; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">13</FONT></TD>
    <TD STYLE="border-right: Black 3px double; border-bottom: Black 1px solid; font: 12pt Tahoma, Helvetica, Sans-Serif; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt"><FONT STYLE="font: 10pt Times New Roman, Times, Serif">Percent of Class Represented by Amount in Row (11) 9.985% </FONT><FONT STYLE="font: 9pt Times New Roman, Times, Serif"><SUP>1,2</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: Black 1px solid; border-bottom: Black 3px double; border-left: Black 3px double; padding: 6pt; text-align: center; font-family: Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">14</FONT></TD>
    <TD STYLE="border-right: Black 3px double; border-bottom: Black 3px double; padding: 6pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 36pt">IN</P>

        <DIV STYLE="font-size: 1pt; border-top: Black 1px solid; margin-right: 36pt">&nbsp;</DIV>

        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

        <DIV STYLE="font-size: 1pt; border-top: Black 1px solid; margin-right: 36pt">&nbsp;</DIV>

        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

        <DIV STYLE="font-size: 1pt; border-top: Black 1px solid; margin-right: 36pt">&nbsp;</DIV></TD></TR>
</TABLE>


<P STYLE="margin: 0"></P>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-top: black 3px double; border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 3px double; padding-top: 6pt; text-align: center; font-size: 10pt; padding-right: 6pt; padding-left: 6pt">1</TD>
    <TD COLSPAN="2" STYLE="border-top: black 3px double; border-right: black 3px double; border-bottom: black 1px solid; padding-right: 6pt; padding-left: 6pt"><P STYLE="font: 6pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Names of Reporting Persons.<BR>
        I.R.S. Identification Nos. of above persons (entities only).</P>
        <P STYLE="font: 6pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Mr. David Kroin</P>

</TD></TR>
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="3" STYLE="border-left: black 3px double; border-right: black 1px solid; padding-top: 6pt; text-align: center; padding-right: 6pt; padding-left: 6pt; width: 6%">2</TD>
    <TD STYLE="padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; width: 92%">Check the Appropriate Box if a Member of a
    Group<SUP> </SUP>(See Instructions)</TD>
    <TD STYLE="border-right: black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; width: 2%">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-left: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(a)&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="border-right: black 3px double; padding-top: 3pt; padding-bottom: 3pt">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top; padding-top: 3pt; padding-left: 6pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;(b)&nbsp;&nbsp;&nbsp;&nbsp;<FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="border-right: black 3px double; padding-top: 3pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 3px double; padding-top: 6pt; text-align: center; padding-right: 6pt; padding-left: 6pt">3</TD>
    <TD COLSPAN="2" STYLE="border-top: black 1px solid; border-right: black 3px double; border-bottom: black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">SEC
    Use Only</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-left: black 3px double; border-right: black 1px solid; padding-top: 6pt; text-align: center; padding-right: 6pt; padding-left: 6pt">4</TD>
    <TD COLSPAN="2" STYLE="border-right: black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">Source of
    Funds (See Instructions) AF</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 3px double; padding-top: 6pt; text-align: center; padding-right: 6pt; padding-left: 6pt">5</TD>
    <TD COLSPAN="2" STYLE="border-top: black 1px solid; border-right: black 3px double; border-bottom: black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">Check
    if Disclosure of Legal Proceedings is Required Pursuant to Items 2(d) or 2(e) <FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-left: black 3px double; border-right: black 1px solid; padding-top: 6pt; text-align: center; padding-right: 6pt; padding-left: 6pt">6</TD>
    <TD COLSPAN="2" STYLE="border-right: black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">Citizenship
    or Place of Organization United States</TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" NOWRAP STYLE="border-top: black 1px solid; border-left: black 3px double; padding-top: 6pt; text-align: center; width: 15%; padding-right: 10pt; padding-left: 10pt; vertical-align: middle">Number
    of Shares<BR>
    Beneficially Owned by<BR>
    Each Reporting Person With</TD>
    <TD STYLE="border-top: black 1px solid; border-right: black 1px solid; border-left: black 1px solid; padding-top: 6pt; text-align: center; width: 6%; padding-right: 6pt; padding-left: 6pt">7</TD>
    <TD STYLE="border-top: black 1px solid; border-right: black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; width: 79%">Sole
    Voting Power -0-</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border: black 1px solid; padding-top: 6pt; text-align: center; padding-right: 6pt; padding-left: 6pt">8</TD>
    <TD STYLE="border-top: black 1px solid; border-right: black 3px double; border-bottom: black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; font-size: 10pt">Shared
    Voting Power 3,046,272 <SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 1px solid; padding-top: 6pt; text-align: center; padding-right: 6pt; padding-left: 6pt">9</TD>
    <TD STYLE="border-bottom: black 1px solid; border-right: black 3px double; padding-top: 3pt; padding-right: 6pt; padding-left: 6pt">Sole
    Dispositive Power -0-</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-left: black 1px solid; border-right: black 1px solid; padding-top: 6pt; text-align: center; padding-right: 6pt; padding-left: 6pt">10</TD>
    <TD STYLE="border-right: black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; font-size: 10pt">Shared
    Dispositive Power 3,046,272 <SUP>1</SUP></TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 3px double; padding-top: 6pt; text-align: center; width: 6%">11</TD>
    <TD STYLE="border-top: black 1px solid; border-right: black 3px double; border-bottom: black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; font-size: 10pt; width: 94%">Aggregate
    Amount Beneficially Owned by Each Reporting Person 3,046,272 <SUP>1</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-left: black 3px double; border-right: black 1px solid; padding-top: 6pt; text-align: center">12</TD>
    <TD STYLE="border-right: black 3px double; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt">Check if the Aggregate
    Amount in Row (11) Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-top: black 1px solid; border-right: black 1px solid; border-bottom: black 1px solid; border-left: black 3px double; padding-top: 6pt; text-align: center">13</TD>
    <TD STYLE="border-top: black 1px solid; border-right: black 3px double; border-bottom: black 1px solid; padding-top: 6pt; padding-right: 6pt; padding-left: 6pt; font-size: 10pt">Percent
    of Class Represented by Amount in Row (11) 9.985% <SUP>1,2</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="border-left: black 3px double; border-bottom: black 3px double; border-right: black 1px solid; padding-top: 6pt; text-align: center; padding-bottom: 6pt">14</TD>
    <TD STYLE="border-bottom: black 3px double; border-right: black 3px double; padding-right: 6pt; padding-left: 6pt; padding-bottom: 6pt"><P STYLE="font: 6pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
                                                                                                                       <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 36pt">IN</P>

        <DIV STYLE="font-size: 1pt; border-top: Black 1px solid; margin-right: 36pt">&nbsp;</DIV>

        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

        <DIV STYLE="font-size: 1pt; border-top: Black 1px solid; margin-right: 36pt">&nbsp;</DIV>

        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

        <DIV STYLE="font-size: 1pt; border-top: Black 1px solid; margin-right: 36pt">&nbsp;</DIV></TD></TR>
</TABLE>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: 10pt Times New Roman, Times, Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
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<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: bold 12pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in">Item 1.</TD>
    <TD>Security and Issuer</TD></TR>
</TABLE>


<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">The title and class
of equity securities to which this statement relates is Common Stock, par value $.001 per share.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-align: left; text-indent: 0in">The name and address
of the principal executive offices of the issuer is</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-align: left; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-align: left; text-indent: 0in">Bovie Medical
Corporation</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-align: left; text-indent: 0in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-align: left; text-indent: 0in">4 Manhattanville
Road, Suite 106, Purchase NY 10577</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-align: left; text-indent: 0in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: bold 12pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in">Item 2.</TD>
    <TD>Identity and Background</TD></TR>
</TABLE>


<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">The identity and background
of the persons filing this statement is as follows:</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">Great Point Partners
LLC (&ldquo;Great Point&rdquo;) is a Delaware limited liability company, with its principal offices at 165 Mason Street, 3<SUP>rd</SUP>
Floor, Greenwich, CT 06830.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">Dr. Jeffrey R. Jay
(&ldquo;Dr. Jay&rdquo;) is an individual with a business address at 165 Mason Street, 3<SUP>rd</SUP> Floor, Greenwich, CT 06830.
Dr. Jay is a citizen of the United States and senior managing member of Great Point.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">Mr. David Kroin (&ldquo;Mr.
Kroin&rdquo;) is an individual with a business address at 165 Mason Street, 3<SUP>rd</SUP> Floor, Greenwich, CT 06830. Mr. Kroin
is a citizen of the United States and special managing member of Great Point.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">None of the Reporting
Persons was during the last five years, convicted of a criminal proceeding (excluding traffic violations or similar misdemeanors).</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">None of the Reporting
Persons was during the last five years, a party to a civil proceeding of a judicial or administrative body of competent jurisdiction
and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting
or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: bold 12pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in">Item 3.</TD>
    <TD>Source and Amount of Funds or Other Consideration</TD></TR>
</TABLE>


<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">Biomedical Value Fund,
L.P. (&ldquo;BVF&rdquo;) used its own funds to purchase 559,291 shares of Common Stock (&ldquo;BVF Shares&rdquo;) and Series B
Preferred Stock convertible into 1,886,735 shares of Common Stock (the &ldquo;BVF Preferred Shares&rdquo;).</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">Biomedical Offshore
Value Fund, Ltd. (&ldquo;BOVF&rdquo;) used its own funds to purchase 312,881 shares of Common Stock (the &ldquo;BOVF Shares&rdquo;)
and Series B Preferred Stock convertible into 1,044,295 shares of Common Stock (the &ldquo;BOVF Preferred Shares&rdquo;).</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">Biomedical Institutional
Value Fund, L.P. (&ldquo;BIVF&rdquo;) used its own funds to purchase 143,832 shares of Common Stock (the &ldquo;BIVF Shares&rdquo;)
and Series B Preferred Stock convertible into 480,065 shares of Common Stock (the &ldquo;BIVF Preferred Shares&rdquo;).</P>

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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">Class D Series of GEF-PS,
LP (&ldquo;GEF-PS&rdquo;) used its own funds to purchase 146,710 shares of Common Stock (the &ldquo;GEF-PS Shares&rdquo;) and Series
B Preferred Stock convertible into 489,669 shares of Common Stock (the &ldquo;GEF-PS Preferred Shares&rdquo;).</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">WS Investments II,
LLC (&ldquo;WS&rdquo;) used its own funds to purchase 17,286 shares of Common Stock (&ldquo;WS Shares&rdquo;) and Series B Preferred
Stock convertible into 70,514 shares of Common Stock (the &ldquo;WS Preferred Shares&rdquo;).</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">The provisions of the
preferred stock described above restrict the conversion of such preferred stock to the extent that, after giving effect to such
conversion, the holder of the preferred stock and its affiliates and any other person or entities with which such holder would
constitute a group would beneficially own in excess of 9.985% of the number of shares of Common Stock of the Issuer outstanding
immediately after giving effect to such conversion (the &ldquo;Beneficial Ownership Cap&rdquo;). Therefore, the reporting persons
could be deemed to beneficially own such number of shares underlying such preferred stock as would result in total beneficial ownership
by such reporting persons up to the Beneficial Ownership Cap.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">See Item 5 below for
information with respect to Great Point, Dr. Jay and Mr. Kroin.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: bold 12pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in">Item 4.</TD>
    <TD>Purpose of Transaction</TD></TR>
</TABLE>


<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">The securities of the
Issuer are held for passive investment purposes.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: bold 12pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in">Item 5.</TD>
    <TD>Interest in Securities of the Issuer</TD></TR>
</TABLE>


<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">BVF beneficially owns
in the aggregate 559,291 BVF Shares and 440,849 BVF Preferred Shares. Such shares in the aggregate constitute 4.723% of the shares
of Common Stock outstanding, computed in accordance with Rule 13d-3. BVF shares voting and dispositive power over the BVF Shares
and BVF Preferred Shares.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">BOVF beneficially owns
in the aggregate 312,881 BOVF Shares and 246,621.5 BOVF Preferred Shares. Such shares in the aggregate constitute 2.642% of the
shares of Common Stock outstanding, computed in accordance with Rule 13d-3. BOVF shares voting and dispositive power over the BOVF
Shares and BOVF Preferred Shares.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">BIVF beneficially owns
in the aggregate 143,832 BIVF Shares and 113,372.5 BIVF Preferred Shares. Such shares in the aggregate constitute 1.215% of the
shares of Common Stock outstanding, computed in accordance with Rule 13d-3. BIVF shares voting and dispositive power of the BIVF
Shares and BIVF Preferred Shares.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">GEF-PS beneficially
owns in the aggregate 146,710 GEF-PS Shares and 115,640.5 GEF-PS Preferred Shares. Such shares in the aggregate constitute 1.239%
of the shares of Common Stock outstanding, computed in accordance with Rule 13d-3. GEF-PS shares voting and dispositive power of
the GEF-PS Shares and GEF-PS Preferred Shares.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">WS beneficially owns
in the aggregate 17,286 WS Shares and 16,652.5 WS Preferred Shares. Such shares in the aggregate constitute 0.166% of the shares
of Common Stock outstanding, computed in accordance with Rule 13d-3. WS shares voting and dispositive power of the WS Shares and
WS Preferred Shares.</P>

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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">The foregoing does
not include Series B Preferred Stock convertible into 2,085,006 shares collectively owned by each of BVF, BOVF, BIVF, GEF-PS, and
WS. The provisions of such preferred stock restrict the conversion of such preferred stock to the extent that, after giving effect
to such conversion, the holder of the preferred stock and its affiliates and any other person or entities with which such holder
would constitute a group would beneficially own in excess of 9.985% of the number of shares of Common Stock of the Issuer outstanding
immediately after giving effect to such conversion (the &ldquo;Beneficial Ownership Cap&rdquo;). Therefore, the reporting persons
could be deemed to beneficially own such number of shares underlying such preferred stock as would result in total beneficial ownership
by such reporting persons up to the Beneficial Ownership Cap.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">Great Point is the
investment manager of each of BVF, BIVF, BOVF, GEF-PS and WS and by virtue of such status may be deemed to be the beneficial owner
of the BMVF Shares, the BVF Preferred shares, the BOVF Shares, the BOVF Preferred Shares, the BIVF Shares, the BIVF Preferred Shares,
the GEF-PS Shares, the GEF-PS Preferred Shares, the WS Shares and WS Preferred Shares. Each of Dr. Jay, as senior managing member
of Great Point, and Mr. Kroin, and special managing member of Great Point, has shared voting and investment power with respect
to the BVF Shares, the BVF Preferred shares, the BOVF Shares, the BOVF Preferred Shares, the BIVF Shares, the BIVF Preferred Shares,
the GEF-PS Shares, the GEF-PS Preferred Shares, the WS Shares and WS Preferred Shares and may be deemed to be the beneficial owner
of such shares. Great Point, Dr. Jay and Mr. Kroin disclaim beneficial ownership of the BVF Shares, the BVF Preferred shares, the
BOVF Shares, the BOVF Preferred Shares, the BIVF Shares, the BIVF Preferred Shares, the GEF-PS Shares, the GEF-PS Preferred Shares,
the WS Shares and WS Preferred Shares except to the extent of any pecuniary interest, and this statement shall not be deemed to
be an admission that they are the beneficial owners of such securities.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: bold 12pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in">Item 6.</TD>
    <TD>Contracts, Arrangements, Understandings or Relationships with Respect to Securities of the Issuer</TD></TR>
</TABLE>


<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">Not applicable.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: bold 12pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 1in">Item 7.</TD>
    <TD>Material to be Filed as Exhibits</TD></TR>
</TABLE>


<P STYLE="font: bold 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in; text-indent: -1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">The following documents
are filed as exhibits and are incorporated herein.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 1in">EXHIBIT A: Joint Filing Agreement, dated as of November
22, 2016.</P>

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<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><FONT STYLE="font-weight: normal"><I>Signature</I></FONT></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 1in">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Date: November 22, 2016</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 12pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">Great Point Partners, LLC</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; width: 50%">&nbsp;</TD>
    <TD STYLE="text-align: left; width: 3%">&nbsp;</TD>
    <TD STYLE="text-align: left; width: 37%">&nbsp;</TD>
    <TD STYLE="text-align: left; width: 10%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">By:&nbsp;</TD>
    <TD STYLE="text-align: left; border-bottom: Black 1px solid; padding-left: 10pt">/s/ Dr. Jeffrey R. Jay</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-left: 10pt">Name: Dr. Jeffrey R. Jay</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-left: 10pt">Title: Senior Managing Member</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left; border-bottom: Black 1px solid; padding-left: 35pt">/s/ Dr. Jeffrey R. Jay</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">Dr. Jeffrey R. Jay, individually</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left; border-bottom: Black 1px solid; padding-left: 35pt">/s/ Mr. David Kroin</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">Mr. David Kroin, individually</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><B>Exhibit A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>AGREEMENT REGARDING THE JOINT FILING
OF<BR>
AMENDMENT NO. 1 TO SCHEDULE 13D</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">The undersigned hereby agree as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 12pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-size: 11pt">(i)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 11pt">Each of them is individually eligible to use the Amendment No. 1
to Schedule 13D to which this Exhibit is attached, and such Schedule 13D is filed on behalf of each of them; and</FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 12pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" WIDTH="100%" STYLE="font: 12pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt"><TR STYLE="vertical-align: top">
<TD STYLE="width: 0.5in"></TD><TD STYLE="width: 0.5in"><FONT STYLE="font-size: 11pt">(ii)</FONT></TD><TD STYLE="text-align: justify"><FONT STYLE="font-size: 11pt">Each of them is responsible for the timely filing of such Amendment
No. 1 to Schedule 13D and any amendments thereto, and for the completeness and accuracy of the information concerning such person
contained therein; but none of them is responsible for the completeness or accuracy of the information concerning the other persons
making the filing, unless such person knows or has reason to believe that such information is inaccurate.</FONT></TD></TR></TABLE>

<P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 12pt Times New Roman, Times, Serif">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" BORDER="0" STYLE="width: 100%; margin-top: 0pt; margin-bottom: 0pt; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; width: 0.5in">Date:</TD>
    <TD STYLE="text-align: left">November 22, 2016</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">Great Point Partners, LLC</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; width: 50%">&nbsp;</TD>
    <TD STYLE="text-align: left; width: 3%">&nbsp;</TD>
    <TD STYLE="text-align: left; width: 37%">&nbsp;</TD>
    <TD STYLE="text-align: left; width: 10%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">By:&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid; text-align: left; padding-left: 10pt">/s/ Dr. Jeffrey R. Jay</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-left: 10pt">Name: Dr. Jeffrey R. Jay</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left; padding-left: 10pt">Title: Senior Managing Member</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid; text-align: left; padding-left: 30pt">/s/ Dr. Jeffrey R. Jay</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">Dr. Jeffrey R. Jay, individually</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid; text-align: left; padding-left: 30pt">/s/ Mr. David Kroin</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: left">Mr. David Kroin, individually</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
</TABLE>


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