<SEC-DOCUMENT>0000930413-17-000560.txt : 20170214
<SEC-HEADER>0000930413-17-000560.hdr.sgml : 20170214
<ACCEPTANCE-DATETIME>20170214162326
ACCESSION NUMBER:		0000930413-17-000560
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20170214
DATE AS OF CHANGE:		20170214

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			BOVIE MEDICAL Corp
		CENTRAL INDEX KEY:			0000719135
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				112644611
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-35626
		FILM NUMBER:		17609302

	BUSINESS ADDRESS:	
		STREET 1:		4 MANHATTANVILLE ROAD, SUITE 106
		CITY:			PURCHASE
		STATE:			NY
		ZIP:			10577
		BUSINESS PHONE:		800-537-2790

	MAIL ADDRESS:	
		STREET 1:		4 MANHATTANVILLE ROAD, SUITE 106
		CITY:			PURCHASE
		STATE:			NY
		ZIP:			10577

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	BOVIE MEDICAL CORP
		DATE OF NAME CHANGE:	19990216

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AN CON GENETICS INC
		DATE OF NAME CHANGE:	19920703

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			GREAT POINT PARTNERS LLC
		CENTRAL INDEX KEY:			0001281446
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
		BUSINESS PHONE:		203 971-3300

	MAIL ADDRESS:	
		STREET 1:		165 MASON STREET, 3RD FLOOR
		CITY:			GREENWICH
		STATE:			CT
		ZIP:			06830
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>c87427_13ga.htm
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B><BR>
<B>SECURITIES AND EXCHANGE COMMISSION</B><BR>
<B>Washington, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Schedule 13G/A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Under the Securities Exchange Act of
1934</B></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Amendment No. 1)*</B></P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">Bovie Medical Corporation</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Name of Issuer)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">Common Stock</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Title of Class of Securities)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">10211F100</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(CUSIP Number)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center; border-bottom: Black 1px solid">December 31, 2016</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">(Date of Event which Requires Filing of this Statement)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">Check the appropriate box to designate the rule pursuant to which this Schedule is filed:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; text-align: left"><FONT STYLE="font-family: Wingdings">x</FONT></TD>
    <TD STYLE="width: 96%; text-align: left">Rule 13d-1(b)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="text-align: left">Rule 13d-1(c)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD STYLE="text-align: left">Rule 13d-1(d)</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">*The remainder of this cover page shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The information required in the remainder
of this cover page shall not be deemed to be &ldquo;filed&rdquo; for the purpose of Section 18 of the Securities Exchange Act of
1934 (&ldquo;Act&rdquo;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions
of the Act (however, see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: left"><B>Persons who respond to the collection of
information contained in this form are not required to respond unless the form displays a currently valid OMB control number.</B></P>

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    <TD STYLE="width: 25%; border: windowtext 1pt solid; text-align: center; vertical-align: middle"><FONT STYLE="font-size: 12pt">CUSIP No. &nbsp;&nbsp;10211F100</FONT></TD>
    <TD STYLE="vertical-align: middle; width: 57%; border-right: windowtext 1pt solid; text-align: center"><FONT STYLE="font-size: 16pt"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 18%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; text-align: left; padding-left: 5pt; vertical-align: middle">Page
    2 of 10  Pages</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>1.</B></TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>NAMES OF REPORTING PERSONS</B></P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">Great Point Partners, LLC</P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES
        ONLY):</P>

<P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">37-1475292</P>

</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>2.</B></TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt"><B>CHECK
    THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 36pt; text-align: center; padding-top: 5pt">&nbsp;</TD>
    <TD STYLE="width: 36pt; padding-left: 5pt; padding-top: 5pt">(a)</TD>
    <TD STYLE="padding-left: 5pt; padding-top: 5pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-left: 5pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="padding-left: 5pt">(b)</TD>
    <TD STYLE="padding-left: 5pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-left: 5pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="text-align: center; padding-bottom: 10pt; vertical-align: bottom; padding-top: 5pt"><B>3.</B></TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt; padding-bottom: 10pt; text-align: left; vertical-align: top; padding-top: 5pt"><B>SEC
    USE ONLY</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 5pt"><B>4.</B></TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt; padding-top: 5pt"><B>CITIZENSHIP
    OR PLACE OF ORGANIZATION</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt">USA</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD STYLE="padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-left: 5pt">&nbsp;</TD></TR>
</TABLE>



<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="width: 20%; text-align: center; vertical-align: middle"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>NUMBER OF SHARES</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>BENEFICIALLY</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>OWNED BY EACH</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>REPORTING PERSON</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>WITH</B></P>
        <P STYLE="margin: 0pt 0">&nbsp;</P></TD>
    <TD STYLE="width: 36pt; text-align: center; font: 10pt Times New Roman, Times, Serif"><B>5.</B></TD>
    <TD STYLE="width: 54%; font: 10pt Times New Roman, Times, Serif"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>SOLE VOTING POWER</B></P>
                                                                     <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="margin: 0pt 0; text-align: center; font: 10pt Times New Roman, Times, Serif">0</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 5pt Times New Roman, Times, Serif">&nbsp;</P></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif"><B>6.</B></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>SHARED VOTING POWER</B></P>

<P STYLE="margin: 0pt 0; text-align: center; font: 10pt Times New Roman, Times, Serif">3,084,268<SUP>1</SUP></P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 5pt Times New Roman, Times, Serif">&nbsp;</P></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif"><B>7.</B></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>SOLE DISPOSITIVE POWER</B></P>
                                                         <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>

<P STYLE="margin: 0pt 0; text-align: center; font: 10pt Times New Roman, Times, Serif">0</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 5pt Times New Roman, Times, Serif">&nbsp;</P></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; font: 10pt Times New Roman, Times, Serif"><B>8.</B></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>SHARED DISPOSITIVE POWER</B></P>

<P STYLE="margin: 0pt 0; text-align: center; font: 10pt Times New Roman, Times, Serif">3,084,268<SUP>1</SUP></P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 5pt Times New Roman, Times, Serif">&nbsp;</P></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>9.</B></TD>
    <TD COLSPAN="2"><B>AGGREGATE
    AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 5pt; padding-top: 5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-bottom: 5pt; padding-left: 36pt; padding-top: 5pt">3,084,268<SUP>1</SUP></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 36pt; text-align: center"><B>10.</B></TD>
    <TD STYLE="vertical-align: top"><B>CHECK
    BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</B> (See Instructions)</TD>
    <TD STYLE="vertical-align: bottom; width: 36pt; text-align: center"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>11.</B></TD>
    <TD COLSPAN="2"><B>PERCENT
    OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 5pt; padding-top: 5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 36pt; padding-bottom: 5pt; padding-top: 5pt">9.985%<SUP>1,2</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>12.</B></TD>
    <TD COLSPAN="2"><B>TYPE
    OF REPORTING PERSON</B> (See Instructions)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 36pt; padding-top: 5pt">IA</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%"><FONT STYLE="color: black"><SUP>1</SUP></FONT></TD>
    <TD STYLE="width: 96%; text-align: justify">Consists of (i) 3,055,000 shares of Common Stock owned collectively by Biomedical
    Value Fund, LP (&ldquo;BVF&rdquo;), Biomedical Offshore Value Fund, Ltd. (&ldquo;BOVF&rdquo;), Biomedical Institutional Value
    Fund, LP (&ldquo;BIVF&rdquo;), Class D Series of GEF-PS, LP (&ldquo;GEF-PS&rdquo;) and WS Investments II, LLC (&ldquo;WS&rdquo;),
    and (ii) 29,268 shares issuable upon conversion of Series A 6% preferred stock collectively owned by each of BVF, BOVF, BIVF,
    GEF-PS, and WS. Does not include: (i) Series A 6% preferred stock convertible into 1,922,010 shares, collectively owned by
    each of BVF, BOVF, BIVF, GEF-PS, and WS. The provisions of such preferred stock restrict the conversion of such preferred
    stock to the extent that, after giving effect to such conversion, the holder of the preferred stock and its affiliates and
    any other person or entities with which such holder would constitute a group would beneficially own in excess of 9.985% of
    the number of shares of Common Stock of the Issuer outstanding immediately after giving effect to such conversion or exercise
    (the &ldquo;Ownership Cap&rdquo;). Therefore, the reporting persons could be deemed to beneficially own such number of shares
    underlying such preferred stock as would result in total beneficial ownership by such reporting persons up to the Ownership
    Cap.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: justify">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><FONT STYLE="color: black"><SUP>2</SUP></FONT></TD>
    <TD STYLE="text-align: justify">Based on a total of 30,859,753 shares outstanding, as reported to the Reporting Persons by
    the Issuer.</TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify"></P>
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    <TD STYLE="width: 25%; border: windowtext 1pt solid; text-align: center; vertical-align: middle"><FONT STYLE="font-size: 12pt">CUSIP No. &nbsp;&nbsp;10211F100</FONT></TD>
    <TD STYLE="vertical-align: middle; width: 57%; border-right: windowtext 1pt solid; text-align: center"><FONT STYLE="font-size: 16pt"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 18%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; text-align: left; vertical-align: middle; padding-left: 5pt">Page
    3 of 10  Pages</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><B>1.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt">
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>NAMES OF REPORTING PERSONS</B></P>
        <P STYLE="font: 5pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Dr. Jeffrey R. Jay, M.D.</P>
        <P STYLE="font: 5pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
        <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</P>
        </TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><FONT STYLE="font-size: 10pt"><B>2.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt"><FONT STYLE="font-size: 10pt"><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 36pt">&nbsp;</TD>
    <TD STYLE="width: 36pt; padding-left: 5pt"><FONT STYLE="font-size: 10pt">(a)</FONT></TD>
    <TD STYLE="padding-left: 5pt"><FONT STYLE="font: 10pt Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-left: 5pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 5pt"><FONT STYLE="font-size: 10pt">(b)</FONT></TD>
    <TD STYLE="padding-left: 5pt"><FONT STYLE="font: 10pt Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="padding-left: 5pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="text-align: center; padding-top: 5pt; padding-bottom: 20pt"><FONT STYLE="font-size: 10pt"><B>3.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt; padding-top: 5pt; padding-bottom: 20pt"><FONT STYLE="font-size: 10pt"><B>SEC USE ONLY</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 5pt; padding-bottom: 5pt"><FONT STYLE="font-size: 10pt"><B>4.</B></FONT></TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt; padding-top: 5pt; padding-bottom: 5pt"><FONT STYLE="font-size: 10pt"><B>CITIZENSHIP OR PLACE OF ORGANIZATION</B></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-bottom: 5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt; padding-bottom: 5pt"><FONT STYLE="font-size: 10pt">USA</FONT></TD></TR>
</TABLE>


<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="width: 20%; text-align: center; vertical-align: middle"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>NUMBER OF SHARES</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>BENEFICIALLY</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>OWNED BY EACH</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>REPORTING PERSON</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>WITH</B></P>

</TD>
    <TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif; text-align: center"><B>5.</B></TD>
    <TD STYLE="width: 54%; font: 10pt Times New Roman, Times, Serif"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>SOLE VOTING POWER</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 10pt Times New Roman, Times, Serif">0</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 5pt Times New Roman, Times, Serif">&nbsp;</P></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><B>6.</B></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>SHARED VOTING POWER</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 10pt Times New Roman, Times, Serif">3,084,268<SUP>1</SUP></P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 5pt Times New Roman, Times, Serif">&nbsp;</P></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><B>7.</B></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>SOLE DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 10pt Times New Roman, Times, Serif">0</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 5pt Times New Roman, Times, Serif">&nbsp;</P></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><B>8.</B></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>SHARED DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 10pt Times New Roman, Times, Serif">3,084,268<SUP>1</SUP></P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 5pt Times New Roman, Times, Serif">&nbsp;</P></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>9.</B></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 5pt"><B>AGGREGATE
    AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 5pt; padding-bottom: 5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 5pt 6pt 5pt 36pt">3,084,268<SUP>1</SUP></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 36pt; text-align: center"><B>10.</B></TD>
    <TD STYLE="vertical-align: top; padding-right: 6pt; padding-left: 5pt"><B>CHECK
    BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</B> (See Instructions)</TD>
    <TD STYLE="vertical-align: bottom; width: 36pt; text-align: center"><FONT STYLE="font: 10pt Wingdings">o</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding-right: 6pt; padding-left: 5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; text-align: center">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>11.</B></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 5pt"><B>PERCENT
    OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 5pt; padding-bottom: 5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 5pt 6pt 5pt 36pt">9.985%<SUP>1, 2</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>12.</B></TD>
    <TD COLSPAN="2" STYLE="padding-right: 6pt; padding-left: 5pt"><B>TYPE
    OF REPORTING PERSON</B> (See Instructions)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-top: 5pt; padding-left: 36pt">IN</TD></TR>
</TABLE>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt; margin-bottom: 10pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%; font: bold 10pt Arial, Helvetica, Sans-Serif"><TR><TD STYLE="text-align: left; width: 100%"><PAGE></PAGE></TD></TR></TABLE></DIV>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Arial, Helvetica, Sans-Serif">
<TR>
    <TD STYLE="width: 25%; border: windowtext 1pt solid; text-align: center; vertical-align: middle"><FONT STYLE="font-size: 12pt">CUSIP No. &nbsp;&nbsp;10211F100</FONT></TD>
    <TD STYLE="vertical-align: middle; width: 57%; border-right: windowtext 1pt solid; text-align: center"><FONT STYLE="font-size: 16pt"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 18%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; text-align: left; vertical-align: middle; padding-left: 5pt">Page
    4 of 10  Pages</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>1.</B></TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt; font: 10pt Times New Roman, Times, Serif"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>NAMES OF REPORTING PERSONS</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">Mr. David Kroin</P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif">I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):</P>
        </TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>2.</B></TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt; font: 10pt Times New Roman, Times, Serif"><B>CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 36pt">&nbsp;</TD>
    <TD STYLE="width: 36pt; padding-left: 5pt; font: 10pt Times New Roman, Times, Serif">(a)</TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; padding-left: 5pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 5pt; font: 10pt Times New Roman, Times, Serif">(b)</TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 5pt; font: 10pt Times New Roman, Times, Serif">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: #CCCCCC">
    <TD STYLE="text-align: center; padding-top: 5pt; padding-bottom: 20pt"><B>3.</B></TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt; font: 10pt Times New Roman, Times, Serif; padding-top: 5pt; padding-bottom: 20pt"><B>SEC USE ONLY</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 5pt"><B>4.</B></TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt; font: 10pt Times New Roman, Times, Serif; padding-top: 5pt"><B>CITIZENSHIP OR PLACE OF ORGANIZATION</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 5pt; padding-bottom: 5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 5pt; font: 10pt Times New Roman, Times, Serif; padding-top: 5pt; padding-bottom: 5pt">USA</TD></TR>
</TABLE>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD ROWSPAN="4" STYLE="width: 20%; text-align: center; vertical-align: middle"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>NUMBER OF SHARES</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>BENEFICIALLY</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>OWNED BY EACH</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>REPORTING PERSON</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>WITH</B></P>

</TD>
    <TD STYLE="width: 36pt; font: 10pt Times New Roman, Times, Serif; text-align: center"><B>5.</B></TD>
    <TD STYLE="width: 54%; font: 10pt Times New Roman, Times, Serif"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>SOLE VOTING POWER</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 10pt Times New Roman, Times, Serif">0</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 5pt Times New Roman, Times, Serif">&nbsp;</P></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><B>6.</B></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>SHARED VOTING POWER</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 10pt Times New Roman, Times, Serif">3,084,268<SUP>1</SUP></P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 5pt Times New Roman, Times, Serif">&nbsp;</P></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><B>7.</B></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>SOLE DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 10pt Times New Roman, Times, Serif">0</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 5pt Times New Roman, Times, Serif">&nbsp;</P></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; font: 10pt Times New Roman, Times, Serif">
    <TD STYLE="font: 10pt Times New Roman, Times, Serif; text-align: center"><B>8.</B></TD>
    <TD STYLE="font: 10pt Times New Roman, Times, Serif"><P STYLE="margin: 0pt 0; font: 10pt Times New Roman, Times, Serif"><B>SHARED DISPOSITIVE POWER</B></P>
        <P STYLE="margin: 0pt 0; font: 5pt Times New Roman, Times, Serif">&nbsp;</P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 10pt Times New Roman, Times, Serif">3,084,268<SUP>1</SUP></P>
        <P STYLE="margin: 0pt 0; text-align: center; font: 5pt Times New Roman, Times, Serif">&nbsp;</P></TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>9.</B></TD>
    <TD COLSPAN="2"><B>AGGREGATE
    AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-top: 5pt; padding-bottom: 5pt; padding-left: 36pt">3,084,268<SUP>1</SUP></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; width: 36pt; text-align: center"><B>10.</B></TD>
    <TD STYLE="vertical-align: top"><B>CHECK
    BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES</B> (See Instructions)</TD>
    <TD STYLE="vertical-align: bottom; width: 36pt; text-align: center"><FONT STYLE="font-family: Wingdings">o</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top; text-align: center">&nbsp;</TD>
    <TD STYLE="vertical-align: top">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>11.</B></TD>
    <TD COLSPAN="2"><B>PERCENT
    OF CLASS REPRESENTED BY AMOUNT IN ROW (9)</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center; padding-top: 5pt; padding-bottom: 5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-top: 5pt; padding-bottom: 5pt; padding-left: 36pt">9.985%<SUP>1,2</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center"><B>12.</B></TD>
    <TD COLSPAN="2"><B>TYPE
    OF REPORTING PERSON</B> (See Instructions)</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: center">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-top: 5pt; padding-left: 36pt">IN</TD></TR>
</TABLE>

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<TR>
    <TD STYLE="width: 25%; border: windowtext 1pt solid; text-align: center; vertical-align: middle"><FONT STYLE="font-size: 12pt">CUSIP No. &nbsp;&nbsp;10211F100</FONT></TD>
    <TD STYLE="vertical-align: middle; width: 57%; border-right: windowtext 1pt solid; text-align: center"><FONT STYLE="font-size: 16pt"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 18%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; text-align: left; vertical-align: middle; padding-left: 5pt">Page
    5 of 10  Pages</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2"><B>Item 1.</B></TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 54pt">&nbsp;</TD>
    <TD STYLE="width: 24pt">(a)</TD>
    <TD>Name of Issuer</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Bovie Medical Corporation</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(b)</TD>
    <TD>Address of Issuer&rsquo;s Principal Executive Offices</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>4 Manhattanville Road, Suite 106, Purchase, NY 10577</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="3"><B>Item 2.</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(a)</TD>
    <TD>Name of Person Filing</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 24pt">Great Point Partners, LLC</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 24pt">Dr. Jeffrey R. Jay, M.D.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 24pt">Mr. David Kroin</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">The Reporting Persons have entered into a Joint Filing Agreement, dated February 14, 2017, a copy of which is filed with this Schedule 13G/A as Exhibit A, pursuant to which the Reporting Persons have agreed to file this statement jointly in accordance with the provisions of Rule 13d-1(k)(1) under the Act.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(b)</TD>
    <TD>Address of Principal Business Office, or if none, Residence</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>The address of the principal business office of each of the Reporting
    Persons is</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 24pt">165 Mason Street, 3rd Floor</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="padding-left: 24pt">Greenwich, CT 06830</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(c)</TD>
    <TD>Citizenship</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="text-align: justify">Great Point Partners, LLC is a limited liability company organized under the laws of the State of Delaware. Dr. Jeffrey R. Jay, M.D. is a citizen of the United States. Mr. David Kroin is a citizen of the United States.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(d)</TD>
    <TD>Title of Class of Securities </TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Common Stock</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(e)</TD>
    <TD>CUSIP Number</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>10211F100</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD><B>Item 3.</B></TD>
    <TD COLSPAN="3"><B>If this statement is filed pursuant to &sect;240.13d-1(b)
        or 240.13d.2(b) or (c), check whether the person filing is a:</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 54pt">&nbsp;</TD>
    <TD STYLE="width: 24pt">&nbsp;</TD>
    <TD STYLE="width: 24pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(a)</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD>Broker or dealer registered under Section 15 of the Act (15 U.S.C. 78o) </TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(b)</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD>Bank as defined in Section 3(a)(6) of the Act (15 U.S.C. 78c).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(c)</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD>Insurance company as defined in Section 3(a)(19) of the Act (15. U.S.C. 78c).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(d)</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD>Investment Company registered under Section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(e)</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">x</FONT></TD>
    <TD>An investment adviser in accordance with &sect;240.13d-1(b)(1)(ii)(E).</TD></TR>
</TABLE>

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<TR>
    <TD STYLE="width: 25%; border: windowtext 1pt solid; text-align: center; vertical-align: middle"><FONT STYLE="font-size: 12pt">CUSIP No. &nbsp;&nbsp;10211F100</FONT></TD>
    <TD STYLE="vertical-align: middle; width: 57%; border-right: windowtext 1pt solid; text-align: center"><FONT STYLE="font-size: 16pt"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 18%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; text-align: left; vertical-align: middle; padding-left: 5pt">Page
    6 of 10  Pages</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(f)</TD>
    <TD STYLE="text-align: left"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD>An employee benefit plan or endowment fund in accordance with &sect;240.13d-1(b)(1)(ii)(F).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD STYLE="text-align: left">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 54pt">&nbsp;</TD>
    <TD STYLE="width: 24pt">(g)</TD>
    <TD STYLE="width: 24pt"><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD>A parent holding company or control person in accordance with &sect;240.13d-1(b)(1)(ii)(G).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(h)</TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD>A savings associations as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C. 1813).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(i)</TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD>A church plan that is excluded from the definition of an investment company under Section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C. 80a-3).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(j)</TD>
    <TD><FONT STYLE="font-family: Wingdings">o</FONT></TD>
    <TD>Group, in accordance with &sect;240.13d-1(b)(1)(ii)(J).</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD><B>Item 4.</B></TD>
    <TD COLSPAN="3"><B>Ownership</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="3">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="3">Biomedical Value Fund, L.P. (&ldquo;BVF&rdquo;) is the record owner of 1,444,921 shares of Common Stock (&ldquo;BVF Shares&rdquo;) and Series A 6% preferred stock convertible into 921,858 shares of Common Stock (the &ldquo;BVF Preferred Shares&rdquo;). Great Point Partners, LLC (&ldquo;Great Point&rdquo;) is the investment manager of BVF, and by virtue of such status may be deemed to be the beneficial owner of the BVF Shares and the BVF Preferred Shares. Each of Dr. Jeffrey R. Jay, M.D. (&ldquo;Dr. Jay&rdquo;), as senior managing member of Great Point, and Mr. David Kroin (&ldquo;Mr. Kroin&rdquo;), as special managing member of Great Point, has voting and investment power with respect to the BVF Shares and BVF Preferred Shares, and therefore may be deemed to be the beneficial owner of the BVF Shares and the BVF Preferred Shares. </TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="3">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="3">Biomedical Offshore Value Fund, Ltd. (&ldquo;BOVF&rdquo;) is the record owner of 808,323 shares of Common Stock (the &ldquo;BOVF Shares&rdquo;) and Series A 6% preferred stock convertible into 515,709 shares of Common Stock (the &ldquo;BOVF Preferred Shares&rdquo;). Great Point is the investment manager of BOVF, and by virtue of such status may be deemed to be the beneficial owner of the BOVF Shares and BOVF Preferred Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the BOVF Shares and BOVF Preferred Shares, and therefore may be deemed to be the beneficial owner of the BOVF Shares and BOVF Preferred Shares.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="3">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="3">Biomedical Institutional Value Fund, L.P. (&ldquo;BIVF&rdquo;) is the record owner of 371,588 shares of Common Stock (the &ldquo;BIVF Shares&rdquo;) and Series A 6% preferred stock convertible into 237,073 shares of Common Stock (the &ldquo;BIVF Preferred Shares&rdquo;). Great Point is the investment manager of BIVF, and by virtue of such status may be deemed to be the beneficial owner of the BIVF Shares and BIVF Preferre Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the BIVF Shares and BIVF Preferred Shares, and therefore may be deemed to be the beneficial owner of the BIVF Shares and BIVF Preferred Shares.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="3">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="3">Class D Series of GEF-PS, LP (&ldquo;GEF-PS&rdquo;) is the record owner of 379,021 shares of Common Stock (the &ldquo;GEF-PS Shares&rdquo;) and Series A 6% preferred stock convertible into 241,816 shares of Common Stock (the &ldquo;GEF-PS Preferred Shares&rdquo;). Great Point is the investment manager of GEF-PS, and by virtue of such status may be deemed to be the beneficial owner of the GEF-PS Shares and GEF-PS Preferred Shares. Each of Dr. Jay, as senior managing member of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to the GEF-PS Shares and GEF-PS Preferred Shares, and therefore may be deemed to be the beneficial owner of the GEF-PS Shares and GEF-PS Preferred Shares.</TD></TR>
</TABLE>

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<TR>
    <TD STYLE="border: windowtext 1pt solid; text-align: center; width: 25%; vertical-align: middle"><FONT STYLE="font-size: 12pt">CUSIP No. &nbsp;&nbsp;10211F100</FONT></TD>
    <TD STYLE="vertical-align: middle; border-right: windowtext 1pt solid; text-align: center; width: 57%"><FONT STYLE="font-size: 16pt"><B>13G/A</B></FONT></TD>
    <TD STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; text-align: left; vertical-align: middle; padding-left: 5pt; width: 18%">Page
    7      of  10 Pages</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 54pt">&nbsp;</TD>
    <TD>WS Investments II, LLC (&ldquo;WS&rdquo;) is the record owner of 51,147 shares of Common Stock (&ldquo;WS
    Shares&rdquo;) and Series A 6% preferred stock convertible into 34,822 shares of Common Stock (the &ldquo;WS Preferred Shares&rdquo;).
    Great Point is the investment manager with respect to the WS Shares and WS Preferred Shares, and by virtue of such status
    may be deemed to be the beneficial owner of the WS Shares and WS Preferred Shares. Each of Dr. Jay, as senior managing member
    of Great Point, and Mr. Kroin, as special managing member of Great Point, has voting and investment power with respect to
    the WS Shares and WS Preferred Shares, and therefore may be deemed to be the beneficial owner of the WS Shares and WS Preferred
    Shares. </TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>The provisions of the preferred stock described above restrict the conversion of such preferred stock to the extent that,
    after giving effect to such conversion, the holder of the preferred stock and its affiliates and any other person or entities
    with which such holder would constitute a group would beneficially own in excess of 9.985% of the number of shares of Common
    Stock of the Issuer outstanding immediately after giving effect to such exercise (the &ldquo;Ownership Cap&rdquo;). Therefore,
    the reporting persons could be deemed to beneficially own such number of shares underlying such preferred stock as would result
    in total beneficial ownership by such reporting persons up to the Ownership Cap.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Notwithstanding the above, Great Point, Dr. Jay and Mr. Kroin disclaim beneficial ownership of the BVF Shares, the BVF
    Preferred Shares, the BOVF Shares, the BOVF Preferred Shares, the BIVF Shares, the BIVF Preferred Shares, the GEF-PS Shares,
    the GEF-PS Preferred Shares, the WS Shares and the WS Preferred Shares, except to the extent of their respective pecuniary
    interests.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>Provide the following information regarding the aggregate number and percentage of the class of securities of the issuer
    identified in Item 1.</TD></TR>
</TABLE>


<P STYLE="margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>1.</TD>
    <TD COLSPAN="2" STYLE="padding-left: 36pt; text-indent: -36pt"><B>Great Point Partners, LLC</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding-left: 36pt; text-indent: -36pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(a)</TD>
    <TD COLSPAN="2">Amount beneficially owned: 3,084,268<FONT STYLE="color: black"><SUP>3</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="color: black">(b)</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="color: black">Percent of class:&nbsp;9.985%<SUP>3,4</SUP></FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(c)</TD>
    <TD COLSPAN="2">Number of shares as to which the person has:</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 54pt">&nbsp;</TD>
    <TD STYLE="width: 24pt">&nbsp;</TD>
    <TD STYLE="width: 24pt">(i)</TD>
    <TD>Sole power to vote or to direct the vote:&nbsp;&nbsp;- 0 -</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>(ii)</TD>
    <TD>Shared power to vote or to direct the vote: 3,084,268<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>(iii)</TD>
    <TD>Sole power to dispose or to direct the disposition of: - 0 -.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>(iv)</TD>
    <TD>Shared power to dispose or to direct the disposition of: 3,084,268<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>2.</TD>
    <TD COLSPAN="2"><B>Dr. Jeffrey R. Jay, M.D.</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(a)</TD>
    <TD COLSPAN="2">Amount beneficially owned: 3,084,268<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(b)</TD>
    <TD COLSPAN="2">Percent of class:&nbsp;&nbsp;9.985%<SUP>3,4</SUP></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font-size: 10pt">
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 4%; text-align: left; text-indent: 0pt; font-family: Times New Roman, Times, Serif; font-weight: bold"><FONT STYLE="font-family: Times New Roman, Times, Serif; color: black"><SUP>3</SUP></FONT></TD>
    <TD STYLE="width: 96%; text-align: justify; text-indent: 0pt; font-family: Times New Roman, Times, Serif; font-weight: bold"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-weight: normal">Consists of (i) 3,055,000 shares of Common Stock owned collectively by Biomedical Value Fund, LP (&ldquo;BVF&rdquo;), Biomedical Offshore Value Fund, Ltd. (&ldquo;BOVF&rdquo;), Biomedical Institutional Value Fund, LP (&ldquo;BIVF&rdquo;), Class D Series of GEF-PS, LP (&ldquo;GEF-PS&rdquo;) and WS Investments II, LLC (&ldquo;WS&rdquo;), and (ii) 29,268 shares by issuable upon conversion of Series A 6% preferred stock collectively owned by each of BVF, BOVF, BIVF, GEF-PS, and WS. Does not include: Series A 6% preferred stock convertible into 1,922,010 shares, collectively owned by each of BVF, BOVF, BIVF, GEF-PS, and WS.</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; font-family: Times New Roman, Times, Serif; font-weight: bold; "><FONT STYLE="font-size: 10pt; color: black">&nbsp;</FONT></TD>
    <TD STYLE="text-align: justify; font-family: Times New Roman, Times, Serif; font-weight: bold"><FONT STYLE="font-size: 10pt;  color: black">&nbsp;</FONT></TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; font-family: Times New Roman, Times, Serif; font-weight: bold; "><FONT STYLE="font-size: 10pt; text-underline-style: none; color: black"><SUP>4</SUP></FONT></TD>
    <TD STYLE="text-align: justify; font-family: Times New Roman, Times, Serif; font-weight: bold"><FONT STYLE="font-size: 10pt; font-weight: normal; text-underline-style: none">Based on a total of 30,859,753 shares outstanding, as reported to the Reporting Persons by the Issuer.</FONT></TD></TR>
</TABLE>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Arial, Helvetica, Sans-Serif">
<TR>
    <TD STYLE="border: windowtext 1pt solid; text-align: center; width: 25%; vertical-align: middle"><FONT STYLE="font-size: 12pt">CUSIP No. &nbsp;&nbsp;10211F100</FONT></TD>
    <TD STYLE="vertical-align: middle; border-right: windowtext 1pt solid; text-align: center; width: 57%"><FONT STYLE="font-size: 16pt"><B>13G/A</B></FONT></TD>
    <TD STYLE="border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; text-align: left; vertical-align: middle; padding-left: 5pt; width: 18%">Page
    8           of  10 Pages</TD></TR>
</TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(c)</TD>
    <TD COLSPAN="2">Number of shares as to which the person has:</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 54pt">&nbsp;</TD>
    <TD STYLE="width: 24pt">&nbsp;</TD>
    <TD STYLE="width: 24pt">&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>(i)</TD>
    <TD>Sole power to vote or to direct the vote:&nbsp;&nbsp;0.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>(ii)</TD>
    <TD>Shared power to vote or to direct the vote: 3,084,268<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>(iii)</TD>
    <TD>Sole power to dispose or to direct the disposition of:&nbsp;&nbsp;0.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>(iv)</TD>
    <TD>Shared power to dispose or to direct the disposition of: 3,084,268<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>3.</TD>
    <TD COLSPAN="2"><B>Mr. David Kroin</B></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(a)</TD>
    <TD COLSPAN="2">Amount beneficially owned: 3,084,268<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(b)</TD>
    <TD COLSPAN="2">Percent of class:&nbsp;&nbsp;9.985%<SUP>3,4</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>(c)</TD>
    <TD COLSPAN="2">Number of shares as to which the person has:</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>(i)</TD>
    <TD>Sole power to vote or to direct the vote:&nbsp;&nbsp;0.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>(ii)</TD>
    <TD>Shared power to vote or to direct the vote: 3,084,268<SUP>3</SUP></TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>(iii)</TD>
    <TD>Sole power to dispose or to direct the disposition of:&nbsp;&nbsp;0.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>(iv)</TD>
    <TD>Shared power to dispose or to direct the disposition of: 3,084,268<SUP>3</SUP></TD></TR>
</TABLE>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 72pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0 0pt 54pt; text-align: justify; text-indent: 0pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0pt; font-weight: bold; width: 54pt">Item 5.</TD>
    <TD STYLE="text-indent: 0pt; font-weight: bold">Ownership of Five Percent or Less of a Class</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
    <TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="text-align: left; text-indent: 54pt">If this statement is being filed to report the fact that as of the date hereof each of the Reporting Persons has ceased to be the beneficial owner of more than five percent of the class of securities, check the following <FONT STYLE="font-family: Wingdings">o</FONT>.</TD></TR>

<TR STYLE="vertical-align: top">
    <TD COLSPAN="2" STYLE="text-align: left; text-indent: 54pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 54pt; text-indent: 0pt; font-weight: bold">Item 6.</TD>
    <TD STYLE="text-indent: 0pt; font-weight: bold">Ownership of More
    than Five Percent on Behalf of Another Person:</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
    <TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="text-align: left; text-indent: 0pt">See Item 4.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0pt; font-weight: bold">Item 7.</TD>
    <TD STYLE="text-indent: 0pt; font-weight: bold">Identification and Classification
    of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
    <TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="text-align: left; text-indent: 0pt">Not Applicable.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0pt; font-weight: bold">Item 8.</TD>
    <TD STYLE="text-indent: 0pt; font-weight: bold">Identification and Classification
    of Members of the Group</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
    <TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="text-align: left; text-indent: 0pt">Not Applicable.</TD></TR>

<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0pt; font-weight: bold; width: 54pt">Item 9.</TD>
    <TD STYLE="text-indent: 0pt; font-weight: bold">Notice of Dissolution of Group</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD>
    <TD STYLE="text-indent: 0pt; font-weight: bold">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="text-align: left; text-indent: 0pt">Not Applicable.</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD>
    <TD STYLE="text-align: left; text-indent: 0pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="text-indent: 0pt; font-weight: bold">Item 10.</TD>
    <TD STYLE="text-indent: 0pt; font-weight: bold">Certification</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">By signing below I certify
that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose
of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not
held in connection with or as participant in any transaction having that purpose or effect.</P>

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<TR>
    <TD STYLE="width: 25%; border: windowtext 1pt solid; text-align: center; vertical-align: middle"><FONT STYLE="font-size: 12pt">CUSIP No. &nbsp;&nbsp;10211F100</FONT></TD>
    <TD STYLE="vertical-align: middle; width: 57%; border-right: windowtext 1pt solid; text-align: center"><FONT STYLE="font-size: 16pt"><B>13G/A</B></FONT></TD>
    <TD STYLE="width: 18%; border-top: windowtext 1pt solid; border-right: windowtext 1pt solid; border-bottom: windowtext 1pt solid; text-align: left; vertical-align: middle; padding-left: 5pt">Page
    9           of  10 Pages</TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>
<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><U>SIGNATURE</U></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">After reasonable inquiry
and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">Date: February 14, 2017</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 0pt">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">GREAT POINT PARTNERS, LLC</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 37%">&nbsp;</TD>
    <TD STYLE="width: 10%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>By:&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Dr. Jeffrey R. Jay, M.D.,</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;&nbsp;as senior managing member</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">DR. JEFFREY R. JAY, M.D.</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid">/s/ Mr. David Kroin</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">MR. DAVID KROIN</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right"><U>Exhibit A</U></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"></P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">AGREEMENT REGARDING THE JOINT FILING
OF SCHEDULE 13G/A</P>

<P STYLE="font: bold 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The undersigned hereby agree as follows:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each of them
is individually eligible to use the Schedule 13G/A to which this Exhibit is attached, and such Schedule 13G/A is filed on behalf
of each of them; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">(ii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Each of them
is responsible for the timely filing of such Schedule 13G/A and any amendments thereto, and for the completeness and accuracy of
the information concerning such person contained therein; but none of them is responsible for the completeness or accuracy of the
information concerning the other persons making the filing, unless such person knows or has reason to believe that such information
is inaccurate.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify; text-indent: 36pt">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">Date: February 14, 2017</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse; font: 10pt Times New Roman, Times, Serif">
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">GREAT POINT PARTNERS, LLC</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%">&nbsp;</TD>
    <TD STYLE="width: 3%">&nbsp;</TD>
    <TD STYLE="width: 37%">&nbsp;</TD>
    <TD STYLE="width: 10%">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>By:&nbsp;</TD>
    <TD STYLE="border-bottom: Black 1px solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>Dr. Jeffrey R. Jay, M.D.,</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;&nbsp;as senior managing member</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid">/s/ Dr. Jeffrey R. Jay, M.D.</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">DR. JEFFREY R. JAY, M.D.</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2" STYLE="border-bottom: Black 1px solid">/s/ Mr. David Kroin</TD>
    <TD>&nbsp;</TD></TR>
<TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">MR. DAVID KROIN</TD>
    <TD>&nbsp;</TD></TR>
</TABLE>

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