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Collaboration and License Agreements and Supply Agreements (Tables)
9 Months Ended
Sep. 30, 2023
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]  
Summary of Recognized Revenue

In accordance with the collaboration agreements, the Company recognized revenue as follows:

 

 

 

Three Months Ended

 

 

Nine Months Ended

 

 

 

September 30,

 

 

September 30,

 

 

 

2023

 

 

2022

 

 

2023

 

 

2022

 

 

 

(in thousands)

 

 

(in thousands)

 

Bristol Myers Squibb Company (“BMS”)

 

$

189

 

 

 

4,343

 

 

$

5,591

 

 

 

8,774

 

Merck Sharp & Dohme Corporation (“Merck”)

 

 

83

 

 

 

10,157

 

 

 

2,776

 

 

 

11,367

 

Merck KGaA, Darmstadt, Germany (operating in the United
   States and Canada under the name “EMD Serono”)

 

 

-

 

 

 

166

 

 

 

8

 

 

 

2,200

 

Astellas Pharma Inc. (“Astellas”)

 

 

9,988

 

 

 

4,985

 

 

 

23,593

 

 

 

4,985

 

Tasly Biopharmaceuticals Co., Ltd. (“Tasly”)

 

 

5,072

 

 

 

-

 

 

 

5,072

 

 

 

25,000

 

Vaxcyte

 

 

1,592

 

 

 

1,496

 

 

 

2,970

 

 

 

2,814

 

BioNova Pharmaceuticals, Ltd. (“BioNova”)

 

 

-

 

 

 

4,000

 

 

 

-

 

 

 

4,000

 

Total revenue

 

$

16,924

 

 

$

25,147

 

 

$

40,010

 

 

 

59,140

 

Summary of Deferred Revenue Balance

The following table presents the changes in the Company’s deferred revenue balance from collaboration agreements during the nine months ended September 30, 2023:

 

 

Nine Months Ended

 

 

 

September 30, 2023

 

 

 

(in thousands)

 

Deferred revenue—December 31, 2022

 

$

106,644

 

Additions to deferred revenue

 

 

11,018

 

Recognition of revenue in current period

 

 

(15,525

)

Deferred revenue—September 30, 2023

 

$

102,137

 

2018 BMS Master Services Agreement  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]  
Summary of Recognized Revenue

Revenues under the BMS Agreement and the 2018 BMS Master Services Agreement were as follows:

 

 

 

Three Months Ended

 

 

Nine Months Ended

 

 

 

September 30,

 

 

September 30,

 

 

 

2023

 

 

2022

 

 

2023

 

 

2022

 

 

 

(in thousands)

 

 

(in thousands)

 

Research and development services

 

$

-

 

 

$

107

 

 

$

413

 

 

$

591

 

Materials supply

 

 

189

 

 

 

4,236

 

 

 

5,178

 

 

 

8,183

 

Total revenue

 

$

189

 

 

$

4,343

 

 

$

5,591

 

 

$

8,774

 

2020 Merck Master Services Agreement  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]  
Summary of Recognized Revenue

Revenues under the 2018 Merck Agreement and the 2020 Merck Master Services Agreement were as follows:

 

 

 

Three Months Ended

 

 

Nine Months Ended

 

 

 

September 30,

 

 

September 30,

 

 

 

2023

 

 

2022

 

 

2023

 

 

2022

 

 

 

(in thousands)

 

 

(in thousands)

 

Ongoing performance related to
   unsatisfied performance obligations

 

$

-

 

 

$

-

 

 

$

-

 

 

$

862

 

Contingent payment

 

 

-

 

 

 

10,000

 

 

 

-

 

 

 

10,000

 

Research and development services

 

 

20

 

 

 

136

 

 

 

224

 

 

 

402

 

Materials supply

 

 

63

 

 

 

21

 

 

 

2,552

 

 

 

103

 

Total revenue

 

$

83

 

 

$

10,157

 

 

$

2,776

 

 

$

11,367

 

2019 EMD Serono Supply Agreement  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]  
Summary of Recognized Revenue

Revenues under the EMD Serono agreements were as follows:

 

 

 

Three Months Ended

 

 

Nine Months Ended

 

 

 

September 30,

 

 

September 30,

 

 

 

2023

 

 

2022

 

 

2023

 

 

2022

 

 

 

(in thousands)

 

 

(in thousands)

 

Research and development services

 

$

-

 

 

$

78

 

 

$

6

 

 

$

494

 

Materials supply

 

 

-

 

 

 

88

 

 

 

2

 

 

 

1,706

 

Total revenue

 

$

-

 

 

$

166

 

 

$

8

 

 

$

2,200

 

Supply Agreement | Vaxcyte, Inc.  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]  
Summary of Recognized Revenue

Revenues under the Vaxcyte Supply Agreement were as follows:

 

 

 

Three Months Ended

 

 

Nine Months Ended

 

 

 

September 30,

 

 

September 30,

 

 

 

2023

 

 

2022

 

 

2023

 

 

2022

 

 

 

(in thousands)

 

 

(in thousands)

 

Research and development services

 

$

636

 

 

$

651

 

 

$

1,707

 

 

$

1,794

 

Materials supply

 

 

956

 

 

 

845

 

 

 

1,263

 

 

 

1,020

 

Total revenue

 

$

1,592

 

 

$

1,496

 

 

$

2,970

 

 

$

2,814

 

Astellas License and Collaboration Agreement  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]  
Summary of Recognized Revenue

Revenues under the Astellas Agreement were as follows:

 

 

 

Three Months Ended

 

 

Nine Months Ended

 

 

 

September 30,

 

 

September 30,

 

 

 

2023

 

 

2022

 

 

2023

 

 

2022

 

 

 

(in thousands)

 

 

(in thousands)

 

Ongoing performance related to
   unsatisfied performance obligations

 

$

5,612

 

 

$

1,925

 

 

$

11,423

 

 

$

1,925

 

Research and development services

 

 

1,920

 

 

 

809

 

 

 

4,639

 

 

 

809

 

Financing component on unearned revenue

 

 

2,456

 

 

 

2,251

 

 

 

7,531

 

 

 

2,251

 

Total revenue

 

$

9,988

 

 

$

4,985

 

 

$

23,593

 

 

$

4,985

 

Tasly License Agreement  
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]  
Summary of Recognized Revenue

Revenues under the Tasly License Agreement were as follows:

 

 

Three Months Ended

 

 

Nine Months Ended

 

 

 

September 30,

 

 

September 30,

 

 

 

2023

 

 

2022

 

 

2023

 

 

2022

 

 

 

(in thousands)

 

 

(in thousands)

 

Upfront payment

 

$

 

 

$

 

 

$

 

 

$

25,000

 

Contingent payments

 

 

5,000

 

 

 

 

 

 

5,000

 

 

 

 

Research and development services

 

 

72

 

 

 

 

 

 

72

 

 

 

 

Total revenue

 

$

5,072

 

 

$

 

 

$

5,072

 

 

$

25,000