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Equity Incentive Plans, Equity Inducement Plans, Employee Stock Purchase Plan and Stock-Based Compensation (Tables)

9 Months Ended

Sep. 30, 2024

Share-Based Payment Arrangement [Abstract]

Summary of Option Activity

The following table summarizes option activity under the Company’s 2004 Plan, 2018 Plan and 2021 Plan:

		Shares				Weighted- Average Exercise Price
Stock options outstanding at December 31, 2023			7,905,032			$	11.24
Granted			1,545,209				4.18
Exercised			(63,748	)			4.24
Canceled and forfeited			(481,931	)			10.91
Stock options outstanding at September 30, 2024			8,904,562				10.08
Stock options exercisable at September 30, 2024			6,349,762			$	11.85

Summary of Status and Activity of Non-vested RSUs

A summary of the status and activity of non-vested RSUs during the nine months ended September 30, 2024 is as follows:

		Number of shares				Weighted Average Grant-Date Fair Value
Non-vested December 31, 2023			5,244,873			$	8.31
Granted			2,710,030				4.40
Vested and released			(1,555,054	)			9.71
Canceled and forfeited			(377,115	)			8.00
Non-vested September 30, 2024			6,022,734			$	6.21

Schedule of Stock-Based Compensation Expense Recognized

Total stock-based compensation expense recognized was as follows:

		Three Months Ended								Nine Months Ended
		September 30,								September 30,
		2024				2023				2024				2023
		(in thousands)								(in thousands)
Research and development expense:		$	3,268			$	2,877			$	9,514			$	8,825
General and administrative expense:			3,277				3,126				9,258				9,860
Total		$	6,545			$	6,003			$	18,772			$	18,685

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure of the number and weighted-average grant date fair value for restricted stock units that were outstanding at the beginning and end of the year, and the number of restricted stock units that were granted, vested, or forfeited during the year.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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