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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
CASH FLOWS FROM OPERATING ACTIVITIES: |  |  |
Loss | $ (29,290) | $ (24,609) | $ (32,203)
Adjustments required to reconcile loss to net cash used in operating activities: |  |  |
Depreciation | 946 | 887 | 762
Changes in accrued liability for employee rights upon retirement | 21 | 38 | 106
Share-based compensation expenses | 1,217 | 2,552 | 4,654
Net changes in operating leases | 71 | 5 |
Changes in fair value of marketable securities | 138 | 65 | 29
Finance expenses, net | 12 | 50 | (34)
Changes in operating asset and liabilities: |  |  |
Receivables from collaborative arrangements | 1,967 | (4,120) |
Prepaid expenses and other current assets | 219 | 1,694 | (1,463)
Accounts payable, accrued expenses and other | (542) | 938 | 3,029
Long term receivables |  |  | 1,653
Net cash used in operating activities | (25,241) | (22,500) | (23,467)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |  |
Purchase of property and equipment | (449) | (597) | (1,052)
Bank deposits | (21,400) | 1,000 | 3,000
Restricted long-term deposits | (21) | (10) | 8
Investments in marketable securities | (32,322) | (38,702) | (71,783)
Proceeds from sales and maturity of marketable securities | 51,498 | 54,333 | 15,092
Net cash provided by (used in) investing activities | (2,694) | 16,024 | (54,735)
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
Proceeds from exercise of options granted to employees | 151 |  | 44
Proceeds from issuance of shares and warrants through public offering, net of issuance costs | 21,306 | 10,613 | 78,775
Net proceeds from issuance of shares and warrants to the controlling shareholder through private placement | 5,000 |  |
Net cash provided by financing activities | 26,457 | 10,613 | 78,819
EFFECT OF EXCHANGE RATE ON CASH AND CASH EQUIVALENTS | (12) | (50) | 34
INCREASE (DECREASE) IN CASH AND CASH EQUIVALENTS | (1,490) | 4,087 | 651
CASH AND CASH EQUIVALENTS AND RESRICTED CASH AT BEGINNING OF THE YEAR | 9,762 | 5,675 | 5,024
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH AT END OF THE YEAR | 8,272 | 9,762 | 5,675
Cash and Cash equivalents | 7,122 | 9,412 | 5,325
Restricted cash | 1,150 | 350 | 350
CASH AND CASH EQUIVALENTS AND RESTRICTED CASH SHOWN IN STATEMENT OF CASH FLOWS | 8,272 | 9,762 | 5,675
SUPPLEMENTARY INFORMATION ON INVESTING AND FINANCING ACTIVITIES NOT INVOLVING CASH FLOWS: |  |  |
Recognition of new operating lease ROU and liabilities | 378 | 1,329 |
Conversion of loans from the controlling shareholder |  |  | 65,338
SUPPLEMENTARY INFORMATION: |  |  |
Income taxes paid | 7 |  |
Interest received | $ 770 | $ 1,600 | $ 1,477

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- Definition Interest received on loans and other debt instruments during the current period. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 16 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3337-108585 + Details
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- Definition The cash inflow associated with the amount received from entity's first offering of stock to the public. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with the amount received from entity's raising of capital via private rather than public placement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3255-108585 + Details
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- Definition Amount of cash restricted as to withdrawal or usage. Cash includes, but is not limited to, currency on hand, demand deposits with banks or financial institutions, and other accounts with general characteristics of demand deposits. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 8 -URI http://asc.fasb.org/extlink&oid=121583591&loc=SL98516268-108586 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 942 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.9-03(1)(a)) -URI http://asc.fasb.org/extlink&oid=120398452&loc=d3e534808-122878 Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 944 -SubTopic 210 -Section S99 -Paragraph 1 -Subparagraph (SX 210.7-03(a)(2)) -URI http://asc.fasb.org/extlink&oid=120400017&loc=d3e572229-122910 + Details
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