<SEC-DOCUMENT>0001104659-21-119829.txt : 20210927
<SEC-HEADER>0001104659-21-119829.hdr.sgml : 20210927
<ACCEPTANCE-DATETIME>20210927171416
ACCESSION NUMBER:		0001104659-21-119829
CONFORMED SUBMISSION TYPE:	SC 13G
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20210927
DATE AS OF CHANGE:		20210927
GROUP MEMBERS:		KOH, BONG
GROUP MEMBERS:		SHAH, NIMISH
GROUP MEMBERS:		VENROCK HEALTHCARE CAPITAL PARTNERS EG, L.P.
GROUP MEMBERS:		VENROCK HEALTHCARE CAPITAL PARTNERS III, L.P.
GROUP MEMBERS:		VHCP CO-INVESTMENT HOLDINGS II, LLC
GROUP MEMBERS:		VHCP CO-INVESTMENT HOLDINGS III, LLC
GROUP MEMBERS:		VHCP MANAGEMENT EG, LLC
GROUP MEMBERS:		VHCP MANAGEMENT II, LLC
GROUP MEMBERS:		VHCP MANAGEMENT III, LLC

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			aTYR PHARMA INC
		CENTRAL INDEX KEY:			0001339970
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				203435077
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-88839
		FILM NUMBER:		211282673

	BUSINESS ADDRESS:	
		STREET 1:		3545 JOHN HOPKINS COURT, STE #250
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		858-731-8389

	MAIL ADDRESS:	
		STREET 1:		3545 JOHN HOPKINS COURT, STE #250
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Venrock Healthcare Capital Partners II, L.P.
		CENTRAL INDEX KEY:			0001602264
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G

	BUSINESS ADDRESS:	
		STREET 1:		7 BRYANT PARK
		STREET 2:		23RD FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10018
		BUSINESS PHONE:		650 475 3734

	MAIL ADDRESS:	
		STREET 1:		7 BRYANT PARK
		STREET 2:		23RD FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10018
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G
<SEQUENCE>1
<FILENAME>tm2128581d1_sc13g.htm
<DESCRIPTION>SC 13G
<TEXT>
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<!-- Field: Rule-Page --><DIV STYLE="margin-top: 0; margin-bottom: 0; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

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<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>WASHINGTON, D.C. 20549</B></P>

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<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SCHEDULE 13G</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNDER THE SECURITIES EXCHANGE ACT OF 1934<BR>
(Amendment No.&nbsp;)*</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 24pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>aTyr Pharma,&nbsp;Inc.</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Name of Issuer)</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Common Stock, $0.001 par value</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Title of Class&nbsp;of Securities)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>002120202</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(CUSIP Number)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>September&nbsp;16, 2021</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Date of Event Which Requires Filing of This
Statement)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the appropriate box to designate the rule&nbsp;pursuant to which
this Schedule is filed:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="vertical-align: top; width: 3%; padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-family: Wingdings">&uml;</FONT></TD>
    <TD STYLE="vertical-align: top; width: 95%; padding: 0.25pt; font-size: 10pt">Rule&nbsp;13d-1(b)</TD></TR>
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    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 3%; padding: 0.25pt"><FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT></TD>
    <TD STYLE="vertical-align: top; width: 95%; padding: 0.25pt">Rule&nbsp;13d-1(c)</TD></TR>
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    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 3%; padding: 0.25pt"><FONT STYLE="font-family: Wingdings">&uml;</FONT></TD>
    <TD STYLE="vertical-align: top; width: 95%; padding: 0.25pt">Rule&nbsp;13d-1(d)</TD></TR>
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    <TD STYLE="width: 2%; padding: 0.25pt">*</TD>
    <TD STYLE="width: 98%; padding: 0.25pt">The remainder of this cover page&nbsp;shall be filled out for a reporting person&rsquo;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The information required in the remainder of this cover page&nbsp;shall
not be deemed to be &ldquo;filed&rdquo; for the purpose of Section&nbsp;18 of the Securities Exchange Act of 1934 (&ldquo;Act&rdquo;)
or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see
the Notes).</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt"><B>CUSIP No.&nbsp;002120202</B></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt; text-align: right">Page&nbsp;2 of 17</TD></TR>
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    <TD STYLE="border: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">1. </TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Name of reporting persons</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Venrock Healthcare Capital Partners II, L.P.</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">2.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;<FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT><FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT>
    (b)&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">3.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">SEC USE ONLY</TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">4.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Delaware</P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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  <TR STYLE="background-color: white">
    <TD ROWSPAN="4" STYLE="border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.25pt 2.25pt; width: 10%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Number of</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Shares</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Owned by</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Each</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Reporting</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">With:</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt; width: 5%">5. </TD>
    <TD STYLE="border-right: black 1.5pt solid; vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt; width: 85%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">6.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">7.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-left: black 1.5pt solid; padding: 0.25pt 2.25pt; border-right: black 1.5pt solid; font-size: 10pt">8.</TD>
    <TD STYLE="border-right: black 1.5pt solid; padding: 0.25pt 2.25pt 0.25pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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    <TD STYLE="border: black 1.5pt solid; padding: 0.75pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">9.</TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.75pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">10.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">Check if the Aggregate Amount in Row (9)&nbsp;Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">11.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class&nbsp;Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">6.7%<FONT STYLE="font-size: 10pt"><SUP>3</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">12.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">PN</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">1&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G.</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">2&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Consists of (i)&nbsp;318,101 shares held by Venrock Healthcare Capital Partners II, L.P., (ii)&nbsp;128,969 shares held by VHCP Co-Investment Holdings II, LLC, (iii)&nbsp;545,106 shares held by Venrock Healthcare Capital Partners III, L.P., (iv)&nbsp;54,540 shares held by VHCP Co-Investment Holdings III, LLC and (v)&nbsp;768,284 shares held by Venrock Healthcare Capital Partners EG, L.P. </TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">3&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">This percentage is calculated based upon 27,088,620 shares of the Issuer&rsquo;s Common Stock outstanding after the closing of the Issuer&rsquo;s public offering, as reported in the Issuer&rsquo;s prospectus supplement dated September&nbsp;15, 2021 and filed with the Securities and Exchange Commission on September&nbsp;16, 2021. </TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt"><B>CUSIP No.&nbsp;002120202</B></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt; text-align: right">Page&nbsp;3 of 17</TD></TR>
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    <TD STYLE="border: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">1. </TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Name of reporting persons</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Co-Investment Holdings II, LLC</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
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    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;<FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT><FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT>
    (b)&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">3.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">SEC USE ONLY</TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">4.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Delaware</P></TD></TR>
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    <TD ROWSPAN="4" STYLE="border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.25pt 2.25pt; width: 10%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Number of</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Shares</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Owned by</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Each</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Reporting</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">With:</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt; width: 5%">5. </TD>
    <TD STYLE="border-right: black 1.5pt solid; vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt; width: 85%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">6.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">7.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-left: black 1.5pt solid; padding: 0.25pt 2.25pt; border-right: black 1.5pt solid; font-size: 10pt">8.</TD>
    <TD STYLE="border-right: black 1.5pt solid; padding: 0.25pt 2.25pt 0.25pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
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    <TD STYLE="border: black 1.5pt solid; padding: 0.75pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">9.</TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.75pt 2.25pt 0.75pt 0.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">10.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">Check if the Aggregate Amount in Row (9)&nbsp;Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
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    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">11.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class&nbsp;Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">6.7%<FONT STYLE="font-size: 10pt"><SUP>3</SUP></FONT></P></TD></TR>
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    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">12.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">OO</P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">1&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G.</TD></TR>
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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">2&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Consists of (i)&nbsp;318,101 shares held by Venrock Healthcare Capital Partners II, L.P., (ii)&nbsp;128,969 shares held by VHCP Co-Investment Holdings II, LLC, (iii)&nbsp;545,106 shares held by Venrock Healthcare Capital Partners III, L.P., (iv)&nbsp;54,540 shares held by VHCP Co-Investment Holdings III, LLC and (v)&nbsp;768,284 shares held by Venrock Healthcare Capital Partners EG, L.P. </TD></TR>
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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">3&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">This percentage is calculated based upon 27,088,620 shares of the Issuer&rsquo;s Common Stock outstanding after the closing of the Issuer&rsquo;s public offering, as reported in the Issuer&rsquo;s prospectus supplement dated September&nbsp;15, 2021 and filed with the Securities and Exchange Commission on September&nbsp;16, 2021. </TD></TR>
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    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt"><B>CUSIP No.&nbsp;002120202</B></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt; text-align: right">Page&nbsp;4 of 17</TD></TR>
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    <TD STYLE="border: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">1. </TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Name of reporting persons</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Venrock Healthcare Capital Partners III, L.P.</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">2.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;<FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT><FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT>
    (b)&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">3.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">SEC USE ONLY</TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">4.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Delaware</P></TD></TR>
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    <TD ROWSPAN="4" STYLE="border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.25pt 2.25pt; width: 10%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Number of</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Shares</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Owned by</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Each</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Reporting</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">With:</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt; width: 5%">5. </TD>
    <TD STYLE="border-right: black 1.5pt solid; vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt; width: 85%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
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    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">6.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">7.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-left: black 1.5pt solid; padding: 0.25pt 2.25pt; border-right: black 1.5pt solid; font-size: 10pt">8.</TD>
    <TD STYLE="border-right: black 1.5pt solid; padding: 0.25pt 2.25pt 0.25pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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    <TD STYLE="border: black 1.5pt solid; padding: 0.75pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">9.</TD>
    <TD COLSPAN="7" STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.75pt 2.25pt 0.75pt 0.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">10.</TD>
    <TD COLSPAN="7" STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">Check if the Aggregate Amount in Row (9)&nbsp;Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">11.</TD>
    <TD COLSPAN="7" STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class&nbsp;Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">6.7%<FONT STYLE="font-size: 10pt"><SUP>3</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
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    <TD COLSPAN="7" STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">PN</P></TD></TR>
  <TR>
    <TD STYLE="width: 4%; padding: 0.25pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 6%; padding: 0.25pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; padding: 0.25pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; padding: 0.25pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; padding: 0.25pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; padding: 0.25pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 84%; padding: 0.25pt; font-size: 10pt">&nbsp;</TD></TR>
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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">1&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G.</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">2&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Consists of (i)&nbsp;318,101 shares held by Venrock Healthcare Capital Partners II, L.P., (ii)&nbsp;128,969 shares held by VHCP Co-Investment Holdings II, LLC, (iii)&nbsp;545,106 shares held by Venrock Healthcare Capital Partners III, L.P., (iv)&nbsp;54,540 shares held by VHCP Co-Investment Holdings III, LLC and (v)&nbsp;768,284 shares held by Venrock Healthcare Capital Partners EG, L.P. </TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">3&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">This percentage is calculated based upon 27,088,620 shares of the Issuer&rsquo;s Common Stock outstanding after the closing of the Issuer&rsquo;s public offering, as reported in the Issuer&rsquo;s prospectus supplement dated September&nbsp;15, 2021 and filed with the Securities and Exchange Commission on September&nbsp;16, 2021. </TD></TR>
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    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt"><B>CUSIP No.&nbsp;002120202</B></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt; text-align: right">Page&nbsp;5 of 17</TD></TR>
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    <TD STYLE="border: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">1. </TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Name of reporting persons</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Co-Investment Holdings III, LLC</P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">2.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;<FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT><FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT>
    (b)&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">3.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">SEC USE ONLY</TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">4.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Delaware</P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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  <TR STYLE="background-color: white">
    <TD ROWSPAN="4" STYLE="border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.25pt 2.25pt; width: 10%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Number of</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Shares</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Owned by</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Each</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Reporting</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">With:</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt; width: 5%">5. </TD>
    <TD STYLE="border-right: black 1.5pt solid; vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt; width: 85%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">6.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">7.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-left: black 1.5pt solid; padding: 0.25pt 2.25pt; border-right: black 1.5pt solid; font-size: 10pt">8.</TD>
    <TD STYLE="border-right: black 1.5pt solid; padding: 0.25pt 2.25pt 0.25pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
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    <TD STYLE="border: black 1.5pt solid; padding: 0.75pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">9.</TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.75pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">10.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">Check if the Aggregate Amount in Row (9)&nbsp;Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">11.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class&nbsp;Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">6.7%<FONT STYLE="font-size: 10pt"><SUP>3</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">12.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">OO</P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">1&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G.</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">2&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Consists of (i)&nbsp;318,101 shares held by Venrock Healthcare Capital Partners II, L.P., (ii)&nbsp;128,969 shares held by VHCP Co-Investment Holdings II, LLC, (iii)&nbsp;545,106 shares held by Venrock Healthcare Capital Partners III, L.P., (iv)&nbsp;54,540 shares held by VHCP Co-Investment Holdings III, LLC and (v)&nbsp;768,284 shares held by Venrock Healthcare Capital Partners EG, L.P. </TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">3&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">This percentage is calculated based upon 27,088,620 shares of the Issuer&rsquo;s Common Stock outstanding after the closing of the Issuer&rsquo;s public offering, as reported in the Issuer&rsquo;s prospectus supplement dated September&nbsp;15, 2021 and filed with the Securities and Exchange Commission on September&nbsp;16, 2021. </TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt"><B>CUSIP No.&nbsp;002120202</B></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt; text-align: right">Page&nbsp;6 of 17</TD></TR>
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    <TD STYLE="border: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">1. </TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Name of reporting persons</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Venrock Healthcare Capital Partners EG, L.P.</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">2.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;<FONT STYLE="font-family: Wingdings">x</FONT><FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT>
    (b)&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">3.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">SEC USE ONLY</TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">4.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Delaware</P></TD></TR>
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    <TD ROWSPAN="4" STYLE="border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.25pt 2.25pt; width: 10%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Number of</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Shares</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Owned by</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Each</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Reporting</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">With:</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt; width: 5%">5. </TD>
    <TD STYLE="border-right: black 1.5pt solid; vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">6.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">7.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-left: black 1.5pt solid; padding: 0.25pt 2.25pt; border-right: black 1.5pt solid; font-size: 10pt">8.</TD>
    <TD STYLE="border-right: black 1.5pt solid; padding: 0.25pt 2.25pt 0.25pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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    <TD STYLE="border: black 1.5pt solid; padding: 0.75pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">9.</TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.75pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">10.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">Check if the Aggregate Amount in Row (9)&nbsp;Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">11.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class&nbsp;Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">6.7%<FONT STYLE="font-size: 10pt"><SUP>3</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">12.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">PN</P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">1&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G.</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">2&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Consists of (i)&nbsp;318,101 shares held by Venrock Healthcare Capital Partners II, L.P., (ii)&nbsp;128,969 shares held by VHCP Co-Investment Holdings II, LLC, (iii)&nbsp;545,106 shares held by Venrock Healthcare Capital Partners III, L.P., (iv)&nbsp;54,540 shares held by VHCP Co-Investment Holdings III, LLC and (v)&nbsp;768,284 shares held by Venrock Healthcare Capital Partners EG, L.P. </TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">3&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">This percentage is calculated based upon 27,088,620 shares of the Issuer&rsquo;s Common Stock outstanding after the closing of the Issuer&rsquo;s public offering, as reported in the Issuer&rsquo;s prospectus supplement dated September&nbsp;15, 2021 and filed with the Securities and Exchange Commission on September&nbsp;16, 2021. </TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt"><B>CUSIP No.&nbsp;002120202</B></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt; text-align: right">Page&nbsp;7 of 17</TD></TR>
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    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Name of reporting persons</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Management II, LLC</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">2.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;<FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT><FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT>
    (b)&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">3.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">SEC USE ONLY</TD></TR>
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    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">4.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Delaware</P></TD></TR>
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  <TR STYLE="background-color: white">
    <TD ROWSPAN="4" STYLE="border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.25pt 2.25pt; width: 10%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Number of</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Shares</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Owned by</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Each</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Reporting</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">With:</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt; width: 5%">5. </TD>
    <TD STYLE="border-right: black 1.5pt solid; vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">6.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">7.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-left: black 1.5pt solid; padding: 0.25pt 2.25pt; border-right: black 1.5pt solid; font-size: 10pt">8.</TD>
    <TD STYLE="border-right: black 1.5pt solid; padding: 0.25pt 2.25pt 0.25pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
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    <TD STYLE="border-right: Black 1.5pt solid; border-top: black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.75pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">9.</TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.75pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">10.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">Check if the Aggregate Amount in Row (9)&nbsp;Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">11.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class&nbsp;Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">6.7%<FONT STYLE="font-size: 10pt"><SUP>3</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">12.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">OO</P></TD></TR>
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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">1&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G.</TD></TR>
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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">2&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Consists of (i)&nbsp;318,101 shares held by Venrock Healthcare Capital Partners II, L.P., (ii)&nbsp;128,969 shares held by VHCP Co-Investment Holdings II, LLC, (iii)&nbsp;545,106 shares held by Venrock Healthcare Capital Partners III, L.P., (iv)&nbsp;54,540 shares held by VHCP Co-Investment Holdings III, LLC and (v)&nbsp;768,284 shares held by Venrock Healthcare Capital Partners EG, L.P. </TD></TR>
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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">3&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">This percentage is calculated based upon 27,088,620 shares of the Issuer&rsquo;s Common Stock outstanding after the closing of the Issuer&rsquo;s public offering, as reported in the Issuer&rsquo;s prospectus supplement dated September&nbsp;15, 2021 and filed with the Securities and Exchange Commission on September&nbsp;16, 2021. </TD></TR>
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    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt"><B>CUSIP No.&nbsp;002120202</B></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt; text-align: right">Page&nbsp;8 of 17</TD></TR>
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    <TD STYLE="border: Black 1.5pt solid; padding: 0.25pt 1.75pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">1. </TD>
    <TD STYLE="border-top: Black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: Black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Name of reporting persons</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Management III, LLC</P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">2.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;<FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT><FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT>
    (b)&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">3.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">SEC USE ONLY</TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt">4.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Delaware</P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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  <TR STYLE="background-color: white">
    <TD ROWSPAN="4" STYLE="border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.25pt 2.25pt; width: 10%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Number of</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Shares</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Owned by</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Each</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Reporting</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">With:</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt; width: 5%">5. </TD>
    <TD STYLE="border-right: black 1.5pt solid; vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt; width: 85%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">6.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">7.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-left: black 1.5pt solid; padding: 0.25pt 2.25pt; border-right: black 1.5pt solid; font-size: 10pt">8.</TD>
    <TD STYLE="border-right: black 1.5pt solid; padding: 0.25pt 2.25pt 0.25pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-top: black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.75pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">9.</TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.75pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">10.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">Check if the Aggregate Amount in Row (9)&nbsp;Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">11.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class&nbsp;Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">6.7%<FONT STYLE="font-size: 10pt"><SUP>3</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">12.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">OO</P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">1&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G.</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">2&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Consists of (i)&nbsp;318,101 shares held by Venrock Healthcare Capital Partners II, L.P., (ii)&nbsp;128,969 shares held by VHCP Co-Investment Holdings II, LLC, (iii)&nbsp;545,106 shares held by Venrock Healthcare Capital Partners III, L.P., (iv)&nbsp;54,540 shares held by VHCP Co-Investment Holdings III, LLC and (v)&nbsp;768,284 shares held by Venrock Healthcare Capital Partners EG, L.P. </TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">3&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">This percentage is calculated based upon 27,088,620 shares of the Issuer&rsquo;s Common Stock outstanding after the closing of the Issuer&rsquo;s public offering, as reported in the Issuer&rsquo;s prospectus supplement dated September&nbsp;15, 2021 and filed with the Securities and Exchange Commission on September&nbsp;16, 2021. </TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt"><B>CUSIP No.&nbsp;002120202</B></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt; text-align: right">Page&nbsp;9 of 17</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="border: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">1. </TD>
    <TD STYLE="border-top: Black 1.5pt solid; border-bottom: Black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Name of reporting persons</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Management EG, LLC</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">2.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;<FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT><FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT>
    (b)&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">3.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">SEC USE ONLY</TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">4.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Delaware</P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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  <TR STYLE="background-color: white">
    <TD ROWSPAN="4" STYLE="border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.25pt 2.25pt; width: 10%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Number of</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Shares</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Owned by</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Each</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Reporting</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">With:</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt; width: 5%">5. </TD>
    <TD STYLE="border-right: black 1.5pt solid; vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt; width: 85%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">6.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">7.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-left: black 1.5pt solid; padding: 0.25pt 2.25pt; border-right: black 1.5pt solid; font-size: 10pt">8.</TD>
    <TD STYLE="border-right: black 1.5pt solid; padding: 0.25pt 2.25pt 0.25pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  </TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-top: black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; padding-top: 0.75pt; padding-right: 0.25pt; padding-left: 9.75pt; font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">9.</FONT></TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.75pt 2.25pt 0.75pt 0.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<SUP>2</SUP></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; border-bottom: Black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 9.75pt; font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">10.</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid; border-right: black 1.5pt solid; padding-top: 0.25pt; padding-right: 2.25pt; padding-left: 0.25pt; font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Check if the Aggregate Amount in Row (9)&nbsp;Excludes Certain Shares (See Instructions) </FONT><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; border-bottom: Black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 9.75pt; font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">11.</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class&nbsp;Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">6.7%<SUP>3</SUP></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; border-bottom: Black 1.5pt solid; padding-top: 0.25pt; padding-right: 0.25pt; padding-left: 9.75pt; font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">12.</FONT></TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">OO</P></TD></TR>
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<P STYLE="margin: 0">&nbsp;</P>

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  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.25pt; font-size: 10pt">1&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt; font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G.</TD></TR>
  <TR>
    <TD STYLE="width: 2%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 92%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">2&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Consists of (i)&nbsp;318,101 shares held by Venrock Healthcare Capital Partners II, L.P., (ii)&nbsp;128,969 shares held by VHCP Co-Investment Holdings II, LLC, (iii)&nbsp;545,106 shares held by Venrock Healthcare Capital Partners III, L.P., (iv)&nbsp;54,540 shares held by VHCP Co-Investment Holdings III, LLC and (v)&nbsp;768,284 shares held by Venrock Healthcare Capital Partners EG, L.P. </TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">3&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">This percentage is calculated based upon 27,088,620 shares of the Issuer&rsquo;s Common Stock outstanding after the closing of the Issuer&rsquo;s public offering, as reported in the Issuer&rsquo;s prospectus supplement dated September&nbsp;15, 2021 and filed with the Securities and Exchange Commission on September&nbsp;16, 2021. </TD></TR>
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    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt"><B>CUSIP No.&nbsp;002120202</B></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt; text-align: right">Page&nbsp;10 of 17</TD></TR>
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    <TD STYLE="border-right: Black 1.5pt solid; border-top: black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">1. </TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Name of Reporting Persons</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shah, Nimish</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">2.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;<FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT><FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT>
    (b)&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">3.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">SEC USE ONLY</TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">4.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">United States</P></TD></TR>
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  <TR STYLE="background-color: white">
    <TD ROWSPAN="4" STYLE="border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.25pt 2.25pt; width: 10%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Number of</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Shares</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Owned by</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Each</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Reporting</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">With:</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt; width: 5%">5. </TD>
    <TD STYLE="border-right: black 1.5pt solid; vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt; width: 85%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">6.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">7.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-left: black 1.5pt solid; padding: 0.25pt 2.25pt; border-right: black 1.5pt solid; font-size: 10pt">8.</TD>
    <TD STYLE="border-right: black 1.5pt solid; padding: 0.25pt 2.25pt 0.25pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
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    <TD STYLE="border-right: Black 1.5pt solid; border-top: black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.75pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">9.</TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.75pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">10.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">Check if the Aggregate Amount in Row (9)&nbsp;Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">11.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class&nbsp;Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">6.7%<FONT STYLE="font-size: 10pt"><SUP>3</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">12.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">IN</P></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">1&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G.</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">2&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Consists of (i)&nbsp;318,101 shares held by Venrock Healthcare Capital Partners II, L.P., (ii)&nbsp;128,969 shares held by VHCP Co-Investment Holdings II, LLC, (iii)&nbsp;545,106 shares held by Venrock Healthcare Capital Partners III, L.P., (iv)&nbsp;54,540 shares held by VHCP Co-Investment Holdings III, LLC and (v)&nbsp;768,284 shares held by Venrock Healthcare Capital Partners EG, L.P. </TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">3&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">This percentage is calculated based upon 27,088,620 shares of the Issuer&rsquo;s Common Stock outstanding after the closing of the Issuer&rsquo;s public offering, as reported in the Issuer&rsquo;s prospectus supplement dated September&nbsp;15, 2021 and filed with the Securities and Exchange Commission on September&nbsp;16, 2021. </TD></TR>
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    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt"><B>CUSIP No.&nbsp;002120202</B></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt; text-align: right">Page&nbsp;11 of 17</TD></TR>
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    <TD STYLE="border-right: Black 1.5pt solid; border-top: black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">1. </TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Name of Reporting Persons</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Koh, Bong</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">2.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the Appropriate Box if a Member of a Group (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">(a)&nbsp;<FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#120;</FONT></FONT><FONT STYLE="font-size: 10pt"><SUP>1</SUP></FONT>
    (b)&nbsp;<FONT STYLE="font-family: Wingdings">&uml;</FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">3.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">SEC USE ONLY</TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">4.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Citizenship or Place of Organization</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">United States</P></TD></TR>
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  <TR STYLE="background-color: white">
    <TD ROWSPAN="4" STYLE="border-left: black 1.5pt solid; padding: 0.25pt 0.25pt 0.25pt 2.25pt; width: 10%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Number of</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Shares</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Beneficially</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Owned by</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Each</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Reporting</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">With:</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt; width: 5%">5. </TD>
    <TD STYLE="border-right: black 1.5pt solid; vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt; width: 85%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">6.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Voting Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt; font-size: 10pt">7.</TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Sole Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">0</P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-left: black 1.5pt solid; padding: 0.25pt 2.25pt; border-right: black 1.5pt solid; font-size: 10pt">8.</TD>
    <TD STYLE="border-right: black 1.5pt solid; padding: 0.25pt 2.25pt 0.25pt 5pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Shared Dispositive Power</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-top: black 1.5pt solid; border-bottom: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.75pt 0.25pt 0.75pt 9.75pt; font-size: 10pt; width: 5%">9.</TD>
    <TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.75pt 2.25pt 0.75pt 0.25pt; width: 95%">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Aggregate Amount Beneficially Owned by Each Reporting Person</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">1,815,000<FONT STYLE="font-size: 10pt"><SUP>2</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">10.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid; font-size: 10pt">Check if the Aggregate Amount in Row (9)&nbsp;Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">11.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Percent of Class&nbsp;Represented by Amount in Row (9)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">6.7%<FONT STYLE="font-size: 10pt"><SUP>3</SUP></FONT></P></TD></TR>
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="border-right: Black 1.5pt solid; border-left: Black 1.5pt solid; padding: 0.25pt 0.25pt 0.75pt 9.75pt; border-bottom: Black 1.5pt solid; font-size: 10pt">12.</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 0.25pt 2.25pt 0.75pt 0.25pt; border-right: black 1.5pt solid">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Type of Reporting Person (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">IN</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">1&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G.</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">2&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">Consists of (i)&nbsp;318,101 shares held by Venrock Healthcare Capital Partners II, L.P., (ii)&nbsp;128,969 shares held by VHCP Co-Investment Holdings II, LLC, (iii)&nbsp;545,106 shares held by Venrock Healthcare Capital Partners III, L.P., (iv)&nbsp;54,540 shares held by VHCP Co-Investment Holdings III, LLC and (v)&nbsp;768,284 shares held by Venrock Healthcare Capital Partners EG, L.P. </TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt; font-size: 10pt">3&nbsp;</TD>
    <TD STYLE="width: 98%; padding: 0.25pt; font-size: 10pt">This percentage is calculated based upon 27,088,620 shares of the Issuer&rsquo;s Common Stock outstanding after the closing of the Issuer&rsquo;s public offering, as reported in the Issuer&rsquo;s prospectus supplement dated September&nbsp;15, 2021 and filed with the Securities and Exchange Commission on September&nbsp;16, 2021. </TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: #FEFEFE">
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Page 12 of 17</FONT></TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Introductory Note: This Schedule 13G is filed on behalf of Venrock
Healthcare Capital Partners II, L.P., a limited partnership organized under the laws of the State of Delaware (&ldquo;VHCP II LP&rdquo;),
VHCP Co-Investment Holdings II, LLC, a limited liability company organized under the laws of the State of Delaware (&ldquo;VHCP Co-Investment
II&rdquo;), Venrock Healthcare Capital Partners III, L.P., a limited partnership organized under the laws of the State of Delaware (&ldquo;VHCP
III LP&rdquo;), VHCP Co-Investment Holdings III, LLC, a limited liability company organized under the laws of the State of Delaware (&ldquo;VHCP
Co-Investment III&rdquo;), Venrock Healthcare Capital Partners EG, L.P., a limited partnership organized under the laws of the State of
Delaware (&ldquo;VHCP EG&rdquo;), VHCP Management II, LLC, a limited liability company organized under the laws of the State of Delaware
(&ldquo;VHCP Management II&rdquo;), VHCP Management III, LLC, a limited liability company organized under the laws of the State of Delaware
(&ldquo;VHCP Management III&rdquo;), VHCP Management EG, LLC, a limited liability company organized under the laws of the State of Delaware
(&ldquo;VHCP Management EG&rdquo; and collectively with VHCP II LP, VHCP Co-Investment II, VHCP III LP, VHCP Co-Investment III, VHCP EG,
VHCP Management II and VHCP Management III, the &ldquo;Venrock Entities&rdquo;), Nimish Shah (&ldquo;Shah&rdquo;) and Bong Koh (&ldquo;Koh&rdquo;)
in respect of Common Stock of aTyr Pharma, Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 1.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 2%; padding: 0.25pt">(a)</TD>
    <TD STYLE="vertical-align: top; width: 96%; padding: 0.25pt">Name of Issuer</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">aTyr Pharma,&nbsp;Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 2%; padding: 0.25pt">(b)</TD>
    <TD STYLE="vertical-align: top; width: 96%; padding: 0.25pt">Address of Issuer&rsquo;s Principal Executive Offices</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">3545 John Hopkins Court, Suite&nbsp;#250</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">San Diego, CA 92121</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 2.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 2%; padding: 0.25pt">(a)</TD>
    <TD STYLE="vertical-align: top; width: 96%; padding: 0.25pt">Name of Person Filing</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Venrock Healthcare Capital Partners II, L.P.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Co-Investment Holdings II, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Venrock Healthcare Capital Partners III, L.P.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Co-Investment Holdings III, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Venrock Healthcare Capital Partners EG, L.P.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Management II, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Management III, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Management EG, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Nimish Shah</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Bong Koh</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 2%; padding: 0.25pt">(b)</TD>
    <TD STYLE="vertical-align: top; width: 96%; padding: 0.25pt">Address of Principal Business Office or, if none, Residence</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="width: 14%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 36%; padding: 0.25pt">New York Office:</TD>
    <TD STYLE="vertical-align: top; width: 50%; padding: 0.25pt">Palo Alto Office:</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">7 Bryant Park</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">3340 Hillview Avenue</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">23rd Floor</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Palo Alto, CA 94304</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">New York, NY 10018</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 2%; padding: 0.25pt">(c)</TD>
    <TD STYLE="vertical-align: top; width: 96%; padding: 0.25pt">Citizenship</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">All of the Venrock Entities were organized in Delaware. The individuals
are both United States citizens.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: #FEFEFE">
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Page 13 of 17</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 2%; padding: 0.25pt">(d)</TD>
    <TD STYLE="vertical-align: top; width: 96%; padding: 0.25pt">Title of Class&nbsp;of Securities</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Common Stock, par value $0.001 per share</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 2%; padding: 0.25pt">(e)</TD>
    <TD STYLE="vertical-align: top; width: 96%; padding: 0.25pt">CUSIP Number</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">002120202</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 6%; padding: 0.25pt; text-align: justify"><B>Item 3. </B></TD>
    <TD STYLE="width: 94%; padding: 0.25pt; text-align: justify"><B>If this statement is filed pursuant to &sect;&sect;240.13d-1(b), or 240.13d-2(b)&nbsp;or (c), check whether the person filing is a:</B></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 6%; padding: 0.25pt"><B>Item 4.</B></TD>
    <TD STYLE="width: 94%; padding: 0.25pt"><B>Ownership</B></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 2%; padding: 0.25pt">(a)</TD>
    <TD STYLE="vertical-align: top; width: 96%; padding: 0.25pt">Amount Beneficially Owned as of September&nbsp;27, 2021:</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width: 76%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 83%; padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners II, L.P.</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 15%; padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Co-Investment Holdings II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners III, L.P.</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Co-Investment Holdings III, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners EG, L.P.</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management III, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management EG, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Nimish Shah</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Bong Koh</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 2%; padding: 0.25pt">(b)</TD>
    <TD STYLE="vertical-align: top; width: 96%; padding: 0.25pt">Percent of Class&nbsp;as of September&nbsp;27, 2021:</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 76%; border-collapse: collapse; margin-left: 1.5in">
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 83%; padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners II, L.P.</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 15%; padding: 0.25pt; text-align: right">6.7</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Co-Investment Holdings II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">6.7</TD>
    <TD STYLE="padding: 0.25pt">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners III, L.P.</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">6.7</TD>
    <TD STYLE="padding: 0.25pt">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Co-Investment Holdings III, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">6.7</TD>
    <TD STYLE="padding: 0.25pt">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners EG, L.P.</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">6.7</TD>
    <TD STYLE="padding: 0.25pt">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">6.7</TD>
    <TD STYLE="padding: 0.25pt">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management III, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">6.7</TD>
    <TD STYLE="padding: 0.25pt">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management EG, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">6.7</TD>
    <TD STYLE="padding: 0.25pt">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Nimish Shah</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">6.7</TD>
    <TD STYLE="padding: 0.25pt">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Bong Koh</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">6.7</TD>
    <TD STYLE="padding: 0.25pt">%</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 2%; padding: 0.25pt">(c)</TD>
    <TD STYLE="vertical-align: top; width: 96%; padding: 0.25pt">Number of shares as to which the person has, as of September&nbsp;27, 2021:</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 2%; padding: 0.25pt">(i)</TD>
    <TD STYLE="vertical-align: top; width: 96%; padding: 0.25pt">Sole power to vote or to direct the vote</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 76%; border-collapse: collapse; margin-left: 1.5in">
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 85%; padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners II, L.P.</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 13%; padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Co-Investment Holdings II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners III, L.P.</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Co-Investment Holdings III, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners EG, L.P.</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management III, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management EG, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Nimish Shah</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Bong Koh</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: #FEFEFE">
    <TD STYLE="width: 50%; padding: 0.25pt"><B>CUSIP No.&nbsp;002120202</B></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; text-align: right">Page&nbsp;14 of 17</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 2%; padding: 0.25pt">(ii)</TD>
    <TD STYLE="vertical-align: top; width: 96%; padding: 0.25pt">Shared power to vote or to direct the vote</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width: 76%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 83%; padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners II, L.P.</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 15%; padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Co-Investment Holdings II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners III, L.P.</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Co-Investment Holdings III, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners EG, L.P.</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management III, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management EG, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Nimish Shah</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Bong Koh</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 3%; padding: 0.25pt">(iii)</TD>
    <TD STYLE="vertical-align: top; width: 95%; padding: 0.25pt">Sole power to dispose or to direct the disposition of</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 76%; border-collapse: collapse; margin-left: 1.5in">
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 85%; padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners II, L.P.</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 13%; padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Co-Investment Holdings II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners III, L.P.</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Co-Investment Holdings III, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners EG, L.P.</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management III, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management EG, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Nimish Shah</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Bong Koh</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">0</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 2%; padding: 0.25pt">(iv)</TD>
    <TD STYLE="vertical-align: top; width: 96%; padding: 0.25pt">Shared power to dispose or to direct the disposition of</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" ALIGN="CENTER" STYLE="font: 10pt Times New Roman, Times, Serif; width: 76%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="width: 83%; padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners II, L.P.</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 15%; padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="width: 1%; padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Co-Investment Holdings II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners III, L.P.</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Co-Investment Holdings III, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Venrock Healthcare Capital Partners EG, L.P.</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management III, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">VHCP Management EG, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: #CCEEFF">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Nimish Shah</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: white">
    <TD STYLE="padding: 0.25pt 0.25pt 0.25pt 0.25in; text-indent: -0.25in">Bong Koh</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; text-align: right">1,815,000</TD>
    <TD STYLE="padding: 0.25pt">(1)</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">(1)</TD>
    <TD STYLE="width: 98%; padding: 0.25pt">Consists of (i)&nbsp;318,101 shares held by Venrock Healthcare Capital Partners II, L.P., (ii)&nbsp;128,969 shares held by VHCP Co-Investment Holdings II, LLC, (iii)&nbsp;545,106 shares held by Venrock Healthcare Capital Partners III, L.P., (iv)&nbsp;54,540 shares held by VHCP Co-Investment Holdings III, LLC and (v)&nbsp;768,284 shares held by Venrock Healthcare Capital Partners EG, L.P. VHCP Management II, LLC is the general partner of Venrock Healthcare Capital Partners II, L.P. and the manager of VHCP Co-Investment Holdings II, LLC. VHCP Management III, LLC is the general partner of Venrock Healthcare Capital Partners III, L.P. and the manager of VHCP Co-Investment Holdings III, LLC. VHCP Management EG, LLC is the general partner of Venrock Healthcare Capital Partners EG, L.P. Messrs.&nbsp;Shah and Koh are the voting members of VHCP Management II, LLC, VHCP Management III, LLC and VHCP Management EG, LLC.</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: #FEFEFE">
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; font-size: 10pt; text-align: right"><FONT STYLE="font-family: Times New Roman, Times, Serif; font-size: 10pt">Page 15 of 17</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 6%; padding: 0.25pt"><B>Item 5.</B></TD>
    <TD STYLE="width: 94%; padding: 0.25pt"><B>Ownership of Five Percent or Less of a Class</B></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If this statement is being filed to report the fact that as of the
date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the
following <FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 6%; padding: 0.25pt"><B>Item 6.</B></TD>
    <TD STYLE="width: 94%; padding: 0.25pt"><B>Ownership of More than Five Percent on Behalf of Another Person</B></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not Applicable</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 6%; padding: 0.25pt"><B>Item 7.</B></TD>
    <TD STYLE="width: 94%; padding: 0.25pt"><B>Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.</B></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not Applicable</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 6%; padding: 0.25pt"><B>Item 8.</B></TD>
    <TD STYLE="width: 94%; padding: 0.25pt"><B>Identification and Classification of Members of the Group</B></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not Applicable</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 6%; padding: 0.25pt"><B>Item 9.</B></TD>
    <TD STYLE="width: 94%; padding: 0.25pt"><B>Notice of Dissolution of a Group</B></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not Applicable</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 6%; padding: 0.25pt"><B>Item 10.</B></TD>
    <TD STYLE="width: 94%; padding: 0.25pt"><B>Certification</B></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the
control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction
having that purpose or effect, other than activities solely in connection with a nomination under &sect; 240.14a-11.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: #FEFEFE">
    <TD STYLE="width: 50%; padding: 0.25pt"><B>CUSIP No.&nbsp;002120202</B></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; text-align: right">Page&nbsp;16 of 17</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>SIGNATURE</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">After reasonable inquiry and to the best of my knowledge and belief,&nbsp;I
certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Dated: September&nbsp;27, 2021</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 0.25pt"><B>Venrock Healthcare Capital Partners II, L.P.</B></TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt"><B>Venrock Healthcare Capital Partners III, L.P.</B></TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">VHCP Management II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">VHCP Management III, LLC</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">General Partner</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">General Partner</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding: 0.25pt">Name:</TD>
    <TD STYLE="width: 41%; padding: 0.25pt">David L. Stepp</TD>
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 3%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding: 0.25pt">Name:</TD>
    <TD STYLE="width: 41%; padding: 0.25pt">David L. Stepp</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD STYLE="padding: 0.25pt">Authorized Signatory</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD STYLE="padding: 0.25pt">Authorized Signatory</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 0.25pt"><B>VHCP Co-Investment Holdings II, LLC</B></TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt"><B>VHCP Co-Investment Holdings III, LLC</B></TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">VHCP Management II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">VHCP Management III, LLC</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">Manager</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">Manager</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Name:</TD>
    <TD STYLE="padding: 0.25pt">David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Name:</TD>
    <TD STYLE="padding: 0.25pt">David L. Stepp</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD STYLE="padding: 0.25pt">Authorized Signatory</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD STYLE="padding: 0.25pt">Authorized Signatory</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 0.25pt"><B>VHCP Management II, LLC</B></TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt"><B>VHCP Management III, LLC</B></TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Name:</TD>
    <TD STYLE="padding: 0.25pt">David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Name:</TD>
    <TD STYLE="padding: 0.25pt">David L. Stepp</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD STYLE="padding: 0.25pt">Authorized Signatory</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD STYLE="padding: 0.25pt">Authorized Signatory</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.25pt"><B>Venrock Healthcare Capital Partners EG, L.P.</B></TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt"><B>VHCP Management EG, LLC</B></TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">VHCP Management EG, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">General Partner</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Name:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;&nbsp;David L. Stepp</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;&nbsp;Authorized Signatory</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Name:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.25pt">&nbsp;&nbsp;David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Its:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.25pt">&nbsp;&nbsp;Authorized Signatory</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: top; width: 49%; padding: 0.25pt"><B>Bong Koh</B></TD>
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 49%; padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">David L. Stepp, Attorney-in-fact</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
</TABLE>

<P STYLE="margin: 0"></P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt; width: 49%">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; width: 2%">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt; width: 49%">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt"><B>Nimish Shah</B></TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">David L. Stepp, Attorney-in-fact</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: #FEFEFE">
    <TD STYLE="width: 50%; padding: 0.25pt"><B>CUSIP No.&nbsp;002120202</B></TD>
    <TD STYLE="width: 50%; padding: 0.25pt; text-align: right">Page&nbsp;17 of 17</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>EXHIBITS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">A:</TD>
    <TD STYLE="width: 98%; padding: 0.25pt">Joint Filing Agreement </TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">B:</TD>
    <TD STYLE="width: 98%; padding: 0.25pt">Power of Attorney for Nimish Shah </TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 2%; padding: 0.25pt">C:</TD>
    <TD STYLE="width: 98%; padding: 0.25pt">Power of Attorney for Bong Koh</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXHIBIT&nbsp;A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">JOINT FILING AGREEMENT</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In accordance with Rule&nbsp;13d-1(k)&nbsp;under
the Securities Exchange Act of 1934, as amended, the undersigned agree to the joint filing on behalf of each of them of a statement on
Schedule 13G (including amendments thereto) with respect to the Common Stock of aTyr Pharma,&nbsp;Inc. and further agree that this agreement
be included as an exhibit to such filing. Each party to the agreement expressly authorizes each other party to file on its behalf any
and all amendments to such statement. Each party to this agreement agrees that this joint filing agreement may be signed in counterparts.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">In evidence whereof, the undersigned have caused
this Agreement to be executed on their behalf this 27<FONT STYLE="font-size: 10pt"><SUP>th</SUP></FONT> day of September, 2021.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD COLSPAN="3" STYLE="vertical-align: top; padding: 0.25pt"><B>Venrock Healthcare Capital Partners II, L.P.</B></TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="vertical-align: top; padding: 0.25pt"><B>Venrock Healthcare Capital Partners III, L.P.</B></TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.25pt">VHCP Management II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.25pt">VHCP Management III, LLC</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Its:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.25pt">General Partner</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Its:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.25pt">General Partner</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; width: 3%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 5%; padding: 0.25pt">Name:</TD>
    <TD STYLE="vertical-align: top; width: 41%; padding: 0.25pt">David L. Stepp</TD>
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 3%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 5%; padding: 0.25pt">Name:</TD>
    <TD STYLE="vertical-align: top; width: 41%; padding: 0.25pt">David L. Stepp</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Its:</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Authorized Signatory</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Its:</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Authorized Signatory</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="vertical-align: top; padding: 0.25pt"><B>VHCP Co-Investment Holdings II, LLC</B></TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="vertical-align: top; padding: 0.25pt"><B>VHCP Co-Investment Holdings III, LLC</B></TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.25pt">VHCP Management II, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.25pt">VHCP Management III, LLC</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Its:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.25pt">Manager</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Its:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.25pt">Manager</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Name:</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Name:</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">David L. Stepp</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Its:</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Authorized Signatory</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Its:</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Authorized Signatory</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="vertical-align: top; padding: 0.25pt"><B>VHCP Management II, LLC</B></TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="vertical-align: top; padding: 0.25pt"><B>VHCP Management III, LLC</B></TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Name:</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Name:</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;&nbsp;David L. Stepp</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Its:</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Authorized Signatory</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Its:</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Authorized Signatory</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.25pt"><B>Venrock Healthcare Capital Partners EG, L.P.</B></TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt"><B>VHCP Management EG, LLC</B></TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">By:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">VHCP Management EG, LLC</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">General Partner</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Name:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;&nbsp;David L. Stepp</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">Its:</TD>
    <TD COLSPAN="2" STYLE="padding: 0.25pt">&nbsp;&nbsp;Authorized Signatory</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD COLSPAN="2" STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; width: 5%; padding: 0.25pt">Name:</TD>
    <TD STYLE="vertical-align: top; width: 44%; padding: 0.25pt">David L. Stepp</TD>
    <TD STYLE="width: 51%; padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Its:</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt">Authorized Signatory</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="width: 49%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 49%; padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt"><B>Bong Koh</B></TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">David L. Stepp, Attorney-in-fact</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 49%; padding: 0.25pt"><B>Nimish Shah</B></TD>
    <TD STYLE="width: 2%; padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="width: 49%; padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt">/s/ David L. Stepp</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.25pt">David L. Stepp, Attorney-in-fact</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD>
    <TD STYLE="padding: 0.25pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-indent: 0.25in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

<!-- Field: Page; Sequence: 7 -->
    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXHIBIT&nbsp;B</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">POWER OF ATTORNEY FOR NIMISH SHAH</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">KNOW ALL BY THESE PRESENTS, that the undersigned
hereby constitutes and appoints each of David L. Stepp, Sherman G. Souther and Lisa D. Harris signing individually, the undersigned&rsquo;s
true and lawful attorney-in fact and agent to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="width: 8%; padding: 0.25pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 5%; padding: 0.25pt; text-align: justify">(i)</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt; text-align: justify">prepare execute and file, for and on behalf of the undersigned, any and all documents and filings that are required or advisable to be made with the United States Securities and Exchange Commission, any stock exchange or similar authority, under the Securities Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;), and the rules&nbsp;and regulations promulgated thereunder, including without limitation (a)&nbsp;any Joint Filing Agreement under Rule&nbsp;13d-1(k)&nbsp;of the Exchange Act (or any successor provision thereunder), Schedule 13D and Schedule 13G (or any successor schedules or forms adopted under the Exchange Act ) and any amendments thereto in accordance with Section&nbsp;13 of the Exchange Act and the rules&nbsp;thereunder, and (b)&nbsp;Forms 3, 4 and 5 and any amendments thereto in accordance with Section&nbsp;16(a)&nbsp;of the Exchange Act and the rules&nbsp;thereunder; and </TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="width: 8%; padding: 0.25pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 5%; padding: 0.25pt; text-align: justify">(ii)</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt; text-align: justify">take any other action of any nature whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact&rsquo;s discretion. </TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The undersigned hereby grants to such attorney-in-fact
full power and authority to do and perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise
of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally
present, with full power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact&rsquo;s
substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein
granted. The undersigned acknowledges that the foregoing attorney-in-fact, in serving in such capacity at the request of undersigned,
is not assuming, nor is Venrock assuming, any of the undersigned&rsquo;s responsibilities to comply with the Exchange Act, including without
limitation Sections 13 and 16 of the Exchange Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">This power of Attorney shall remain in full force
and effect until the earliest to occur of (a)&nbsp;the undersigned is no longer required to file any form or document with respect to
the undersigned&rsquo;s holdings of and transactions in securities issued by a company, (b)&nbsp;revocation by the undersigned in a signed
writing delivered to the foregoing attorney-in-fact, or (c)&nbsp;until such attorney-in-fact shall no longer be employed by VR Management,
LLC (or its successor).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">IN WITNESS WHEREOF, the undersigned has cause
this Power of Attorney to be executed as of this 27<FONT STYLE="font-size: 10pt"><SUP>th</SUP></FONT> day of September, 2021.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; border-bottom: black 1pt solid; padding: 0.25pt 0.25pt 0.5pt; text-align: justify">/s/ Nimish Shah</TD>
    <TD STYLE="width: 50%; padding: 0.25pt; text-align: justify">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>EXHIBIT&nbsp;C</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">POWER OF ATTORNEY FOR BONG KOH</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">KNOW ALL BY THESE PRESENTS, that the undersigned
hereby constitutes and appoints each of David L. Stepp, Sherman G. Souther and Lisa D. Harris signing individually, the undersigned&rsquo;s
true and lawful attorney-in fact and agent to:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="width: 8%; padding: 0.25pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 5%; padding: 0.25pt; text-align: justify">(i)</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt; text-align: justify">prepare execute and file, for and on behalf of the undersigned, any and all documents and filings that are required or advisable to be made with the United States Securities and Exchange Commission, any stock exchange or similar authority, under the Securities Exchange Act of 1934, as amended (the &ldquo;Exchange Act&rdquo;), and the rules&nbsp;and regulations promulgated thereunder, including without limitation (a)&nbsp;any Joint Filing Agreement under Rule&nbsp;13d-1(k)&nbsp;of the Exchange Act (or any successor provision thereunder), Schedule 13D and Schedule 13G (or any successor schedules or forms adopted under the Exchange Act ) and any amendments thereto in accordance with Section&nbsp;13 of the Exchange Act and the rules&nbsp;thereunder, and (b)&nbsp;Forms 3, 4 and 5 and any amendments thereto in accordance with Section&nbsp;16(a)&nbsp;of the Exchange Act and the rules&nbsp;thereunder; and </TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="width: 8%; padding: 0.25pt; text-align: justify">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 5%; padding: 0.25pt; text-align: justify">(ii)</TD>
    <TD STYLE="vertical-align: top; padding: 0.25pt; text-align: justify">take any other action of any nature whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and conditions as such attorney-in-fact may approve in such attorney-in-fact&rsquo;s discretion. </TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">The undersigned hereby grants to such attorney-in-fact
full power and authority to do and perform any and every act and thing whatsoever requisite, necessary, or proper to be done in the exercise
of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally
present, with full power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact&rsquo;s
substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the rights and powers herein
granted. The undersigned acknowledges that the foregoing attorney-in-fact, in serving in such capacity at the request of undersigned,
is not assuming, nor is Venrock assuming, any of the undersigned&rsquo;s responsibilities to comply with the Exchange Act, including without
limitation Sections 13 and 16 of the Exchange Act.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">This power of Attorney shall remain in full force
and effect until the earliest to occur of (a)&nbsp;the undersigned is no longer required to file any form or document with respect to
the undersigned&rsquo;s holdings of and transactions in securities issued by a company, (b)&nbsp;revocation by the undersigned in a signed
writing delivered to the foregoing attorney-in-fact, or (c)&nbsp;until such attorney-in-fact shall no longer be employed by VR Management,
LLC (or its successor).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: justify">IN WITNESS WHEREOF, the undersigned has cause
this Power of Attorney to be executed as of this 27<FONT STYLE="font-size: 10pt"><SUP>th</SUP></FONT> day of September, 2021.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 50%; border-bottom: black 1pt solid; padding-bottom: 0.5pt; padding-left: 10pt; text-indent: -10pt">/s/ Bong Koh</TD>
    <TD STYLE="width: 50%; padding-left: 10pt; text-indent: -10pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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</SEC-DOCUMENT>
