<SEC-DOCUMENT>0001104659-22-022863.txt : 20220214
<SEC-HEADER>0001104659-22-022863.hdr.sgml : 20220214
<ACCEPTANCE-DATETIME>20220214161740
ACCESSION NUMBER:		0001104659-22-022863
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20220214
DATE AS OF CHANGE:		20220214
GROUP MEMBERS:		KOH, BONG
GROUP MEMBERS:		SHAH, NIMISH
GROUP MEMBERS:		VENROCK HEALTHCARE CAPITAL PARTNERS EG, L.P.
GROUP MEMBERS:		VENROCK HEALTHCARE CAPITAL PARTNERS III, L.P.
GROUP MEMBERS:		VHCP CO-INVESTMENT HOLDINGS II, LLC
GROUP MEMBERS:		VHCP CO-INVESTMENT HOLDINGS III, LLC
GROUP MEMBERS:		VHCP MANAGEMENT EG, LLC
GROUP MEMBERS:		VHCP MANAGEMENT II, LLC
GROUP MEMBERS:		VHCP MANAGEMENT III, LLC

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			aTYR PHARMA INC
		CENTRAL INDEX KEY:			0001339970
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				203435077
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-88839
		FILM NUMBER:		22632297

	BUSINESS ADDRESS:	
		STREET 1:		3545 JOHN HOPKINS COURT, STE #250
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121
		BUSINESS PHONE:		858-731-8389

	MAIL ADDRESS:	
		STREET 1:		3545 JOHN HOPKINS COURT, STE #250
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Venrock Healthcare Capital Partners II, L.P.
		CENTRAL INDEX KEY:			0001602264
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		7 BRYANT PARK
		STREET 2:		23RD FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10018
		BUSINESS PHONE:		650 475 3734

	MAIL ADDRESS:	
		STREET 1:		7 BRYANT PARK
		STREET 2:		23RD FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10018
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>tm226174d9_sc13ga.htm
<DESCRIPTION>SC 13G/A
<TEXT>
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<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>WASHINGTON, D.C. 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>SCHEDULE 13G/A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>UNDER THE SECURITIES EXCHANGE ACT OF 1934<BR>
(Amendment No. 1)*</B></P>

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<P STYLE="font: 24pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>aTyr Pharma, Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Name of Issuer)</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>Common Stock, $0.001 par value</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Title of Class of Securities)</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>002120202</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(CUSIP Number)</B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>December 31, 2021</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B>(Date of Event Which Requires Filing of This
Statement)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:</P>

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    <TD STYLE="text-align: center; vertical-align: top; width: 0.4in; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Rule 13d-1(b)</FONT></TD></TR>

<TR STYLE="background-color: white">
    <TD STYLE="text-align: center; vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">x</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Rule 13d-1(c)</FONT></TD></TR>

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    <TD STYLE="text-align: center; vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-family: Wingdings; font-size: 10pt">&uml;</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Rule 13d-1(d)</FONT></TD></TR>
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    <TD STYLE="width: 1%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">*</FONT></TD>
    <TD STYLE="width: 99%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.</FONT></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">The information required in the remainder of this cover page shall
not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 (&#8220;Act&#8221;) or otherwise
subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</P>




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    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 2 of 17</FONT></TD></TR>
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<TD STYLE="border-top: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt 3pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD COLSPAN="2" STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">1. </FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Name of reporting persons<BR>
 Venrock Healthcare Capital Partners II, L.P.</TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">2.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Check the Appropriate Box if a Member of a Group (See Instructions)<BR>
 (a) <FONT STYLE="font-family: Wingdings">x</FONT><SUP>1</SUP> (b) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">SEC USE ONLY</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Citizenship or Place of Organization<BR>
 Delaware</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="3" ROWSPAN="4" STYLE="text-align: center; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 0.5pt 3pt">Number of <BR>
Shares <BR>
Beneficially<BR>
 Owned by<BR>
 Each <BR>
Reporting<BR>
 Person<BR>
 With:</TD>
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">5. </FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Voting Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Shared Voting Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Dispositive Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 0.5pt 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; padding: 0.5pt 3pt 0.5pt 0.5pt; vertical-align: top">Shared Dispositive Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-top: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 1.5pt 10.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">Aggregate Amount Beneficially Owned by Each Reporting Person<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Percent of Class Represented by Amount in Row (9)<BR>
 5.6%<SUP>3</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Type of Reporting Person (See Instructions)<BR>
 PN</TD></TR>
<TR>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 5%; padding: 0.5pt">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 85%; padding: 0.5pt">&nbsp;</TD></TR>
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    <TD STYLE="width: 0.25in; font-size: 10pt"><FONT STYLE="font-size: 10pt">1 </FONT></TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.</FONT></TD></TR>

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    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
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    <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">2 </FONT></TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">Consists of (i) 257,664 shares held by Venrock Healthcare Capital Partners II, L.P., (ii) 104,470 shares held by VHCP Co-Investment Holdings II, LLC, (iii) 527,720 shares held by Venrock Healthcare Capital Partners III, L.P., (iv) 52,802 shares held by VHCP Co-Investment Holdings III, LLC and (v) 622,344 shares held by Venrock Healthcare Capital Partners EG, L.P. </FONT></TD></TR>

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    <TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt">&nbsp;</TD></TR>
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    <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">3 </FONT></TD>
    <TD STYLE="font-size: 10pt"><FONT STYLE="font-size: 10pt">This percentage is calculated based upon 27,790,677 shares of the Issuer&#8217;s Common Stock outstanding as of November 9, 2021, as reported in the Issuer&#8217;s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 12, 2021. </FONT></TD></TR>
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    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 3 of 17</FONT></TD></TR>
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<TD STYLE="border-top: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt 3pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD COLSPAN="2" STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">1. </FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Name of reporting persons<BR>
 VHCP Co-Investment Holdings II, LLC</TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">2.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Check the Appropriate Box if a Member of a Group (See Instructions)<BR>
 (a) <FONT STYLE="font-family: Wingdings">x</FONT><SUP>1</SUP> (b) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
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<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">SEC USE ONLY</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Citizenship or Place of Organization<BR>
 Delaware</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="3" ROWSPAN="4" STYLE="text-align: center; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 0.5pt 3pt">Number of <BR>
Shares<BR>
 Beneficially<BR>
 Owned by<BR>
 Each <BR>
Reporting<BR>
 Person <BR>
With:</TD>
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">5. </FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Voting Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Shared Voting Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Dispositive Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 0.5pt 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; padding: 0.5pt 3pt 0.5pt 0.5pt; vertical-align: top">Shared Dispositive Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-top: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 1.5pt 10.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">Aggregate Amount Beneficially Owned by Each Reporting Person<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Percent of Class Represented by Amount in Row (9)<BR>
 5.6%<SUP>3</SUP></TD></TR>
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<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Type of Reporting Person (See Instructions)<BR>
 OO</TD></TR>
<TR>
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<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 5%; padding: 0.5pt">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 85%; padding: 0.5pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.</FONT></TD></TR>

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    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">2 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Consists of (i) 257,664 shares held by Venrock Healthcare Capital Partners II, L.P., (ii) 104,470 shares held by VHCP Co-Investment Holdings II, LLC, (iii) 527,720 shares held by Venrock Healthcare Capital Partners III, L.P., (iv) 52,802 shares held by VHCP Co-Investment Holdings III, LLC and (v) 622,344 shares held by Venrock Healthcare Capital Partners EG, L.P. </FONT></TD></TR>

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    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">3 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">This percentage is calculated based upon 27,790,677 shares of the Issuer&#8217;s Common Stock outstanding as of November 9, 2021, as reported in the Issuer&#8217;s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 12, 2021. </FONT></TD></TR>
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    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 4 of 17</FONT></TD></TR>
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<TD STYLE="border-top: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt 3pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD COLSPAN="2" STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">1. </FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Name of reporting persons<BR>
 Venrock Healthcare Capital Partners III, L.P.</TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">2.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Check the Appropriate Box if a Member of a Group (See Instructions)<BR>
 (a) <FONT STYLE="font-family: Wingdings">x</FONT><SUP>1</SUP> (b) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">SEC USE ONLY</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Citizenship or Place of Organization<BR>
 Delaware</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="3" ROWSPAN="4" STYLE="text-align: center; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 0.5pt 3pt">Number of <BR>
Shares <BR>
Beneficially<BR>
 Owned by<BR>
 Each <BR>
Reporting<BR>
 Person <BR>
With:</TD>
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">5. </FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Voting Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Shared Voting Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Dispositive Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 0.5pt 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; padding: 0.5pt 3pt 0.5pt 0.5pt; vertical-align: top">Shared Dispositive Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-top: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 1.5pt 10.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">Aggregate Amount Beneficially Owned by Each Reporting Person<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD></TR>
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<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Percent of Class Represented by Amount in Row (9)<BR>
 5.6%<SUP>3</SUP></TD></TR>
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<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Type of Reporting Person (See Instructions)<BR>
 PN</TD></TR>
<TR>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 5%; padding: 0.5pt">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 85%; padding: 0.5pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.</FONT></TD></TR>

<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">2 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Consists of (i) 257,664 shares held by Venrock Healthcare Capital Partners II, L.P., (ii) 104,470 shares held by VHCP Co-Investment Holdings II, LLC, (iii) 527,720 shares held by Venrock Healthcare Capital Partners III, L.P., (iv) 52,802 shares held by VHCP Co-Investment Holdings III, LLC and (v) 622,344 shares held by Venrock Healthcare Capital Partners EG, L.P. </FONT></TD></TR>

<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">3 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">This percentage is calculated based upon 27,790,677 shares of the Issuer&#8217;s Common Stock outstanding as of November 9, 2021, as reported in the Issuer&#8217;s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 12, 2021. </FONT></TD></TR>
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    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 5 of 17</FONT></TD></TR>
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<TR STYLE="background-color: white">
<TD STYLE="border-top: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt 3pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD COLSPAN="2" STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">1. </FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Name of reporting persons<BR>
 VHCP Co-Investment Holdings III, LLC</TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">2.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Check the Appropriate Box if a Member of a Group (See Instructions)<BR>
 (a) <FONT STYLE="font-family: Wingdings">x</FONT><SUP>1</SUP> (b) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">SEC USE ONLY</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Citizenship or Place of Organization<BR>
 Delaware</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="3" ROWSPAN="4" STYLE="text-align: center; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 0.5pt 3pt">Number of<BR>
 Shares <BR>
Beneficially<BR>
 Owned by <BR>
Each <BR>
Reporting<BR>
 Person <BR>
With:</TD>
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">5. </FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Voting Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Shared Voting Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Dispositive Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 0.5pt 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; padding: 0.5pt 3pt 0.5pt 0.5pt; vertical-align: top">Shared Dispositive Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-top: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 1.5pt 10.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">Aggregate Amount Beneficially Owned by Each Reporting Person<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Percent of Class Represented by Amount in Row (9)<BR>
 5.6%<SUP>3</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Type of Reporting Person (See Instructions)<BR>
 OO</TD></TR>
<TR>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 5%; padding: 0.5pt">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 85%; padding: 0.5pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.</FONT></TD></TR>

<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">2 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Consists of (i) 257,664 shares held by Venrock Healthcare Capital Partners II, L.P., (ii) 104,470 shares held by VHCP Co-Investment Holdings II, LLC, (iii) 527,720 shares held by Venrock Healthcare Capital Partners III, L.P., (iv) 52,802 shares held by VHCP Co-Investment Holdings III, LLC and (v) 622,344 shares held by Venrock Healthcare Capital Partners EG, L.P. </FONT></TD></TR>

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    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">3 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">This percentage is calculated based upon 27,790,677 shares of the Issuer&#8217;s Common Stock outstanding as of November 9, 2021, as reported in the Issuer&#8217;s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 12, 2021. </FONT></TD></TR>
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    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 6 of 17</FONT></TD></TR>
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<TD STYLE="border-top: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt 3pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD COLSPAN="2" STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">1. </FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Name of reporting persons<BR>
 Venrock Healthcare Capital Partners EG, L.P.</TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">2.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Check the Appropriate Box if a Member of a Group (See Instructions)<BR>
 (a) <FONT STYLE="font-family: Wingdings">x</FONT><SUP>1</SUP> (b) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">SEC USE ONLY</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Citizenship or Place of Organization<BR>
 Delaware</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="3" ROWSPAN="4" STYLE="text-align: center; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 0.5pt 3pt">Number of <BR>
Shares<BR>
 Beneficially <BR>
Owned by <BR>
Each <BR>
Reporting <BR>
Person <BR>
With:</TD>
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">5. </FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Voting Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Shared Voting Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Dispositive Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 0.5pt 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; padding: 0.5pt 3pt 0.5pt 0.5pt; vertical-align: top">Shared Dispositive Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-top: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 1.5pt 10.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">Aggregate Amount Beneficially Owned by Each Reporting Person<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Percent of Class Represented by Amount in Row (9)<BR>
 5.6%<SUP>3</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Type of Reporting Person (See Instructions)<BR>
 PN</TD></TR>
<TR>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 5%; padding: 0.5pt">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 85%; padding: 0.5pt">&nbsp;</TD></TR>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 0.25in; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">1 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.</FONT></TD></TR>

<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">2 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Consists of (i) 257,664 shares held by Venrock Healthcare Capital Partners II, L.P., (ii) 104,470 shares held by VHCP Co-Investment Holdings II, LLC, (iii) 527,720 shares held by Venrock Healthcare Capital Partners III, L.P., (iv) 52,802 shares held by VHCP Co-Investment Holdings III, LLC and (v) 622,344 shares held by Venrock Healthcare Capital Partners EG, L.P. </FONT></TD></TR>

<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">3 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">This percentage is calculated based upon 27,790,677 shares of the Issuer&#8217;s Common Stock outstanding as of November 9, 2021, as reported in the Issuer&#8217;s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 12, 2021. </FONT></TD></TR>
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    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 7 of 17</FONT></TD></TR>
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<TD STYLE="border-top: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt 3pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD COLSPAN="2" STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">1. </FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Name of reporting persons<BR>
 <FONT STYLE="font-size: 10pt">VHCP Management II, LLC</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">2.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Check the Appropriate Box if a Member of a Group (See Instructions)<BR>
 (a) <FONT STYLE="font-family: Wingdings">x</FONT><SUP>1</SUP> (b) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">SEC USE ONLY</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Citizenship or Place of Organization<BR>
 Delaware</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="3" ROWSPAN="4" STYLE="text-align: center; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 0.5pt 3pt">Number of <BR>
Shares <BR>
Beneficially <BR>
Owned by <BR>
Each <BR>
Reporting <BR>
Person <BR>
With:</TD>
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">5. </FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Voting Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Shared Voting Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Dispositive Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 0.5pt 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; padding: 0.5pt 3pt 0.5pt 0.5pt; vertical-align: top">Shared Dispositive Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-top: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 1.5pt 10.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">Aggregate Amount Beneficially Owned by Each Reporting Person<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Percent of Class Represented by Amount in Row (9)<BR>
 5.6%<SUP>3</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Type of Reporting Person (See Instructions)<BR>
 OO</TD></TR>
<TR>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 5%; padding: 0.5pt">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 85%; padding: 0.5pt">&nbsp;</TD></TR>
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    <TD STYLE="width: 0.25in; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">1 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.</FONT></TD></TR>

<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">2 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Consists of (i) 257,664 shares held by Venrock Healthcare Capital Partners II, L.P., (ii) 104,470 shares held by VHCP Co-Investment Holdings II, LLC, (iii) 527,720 shares held by Venrock Healthcare Capital Partners III, L.P., (iv) 52,802 shares held by VHCP Co-Investment Holdings III, LLC and (v) 622,344 shares held by Venrock Healthcare Capital Partners EG, L.P. </FONT></TD></TR>

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    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">3 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">This percentage is calculated based upon 27,790,677 shares of the Issuer&#8217;s Common Stock outstanding as of November 9, 2021, as reported in the Issuer&#8217;s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 12, 2021. </FONT></TD></TR>
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    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 8 of 17</FONT></TD></TR>
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<TD STYLE="border-top: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt 3pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD COLSPAN="2" STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">1. </FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Name of reporting persons<BR>
 <FONT STYLE="font-size: 10pt">VHCP Management III, LLC</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">2.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Check the Appropriate Box if a Member of a Group (See Instructions)<BR>
 (a) <FONT STYLE="font-family: Wingdings">x</FONT><SUP>1</SUP> (b) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">SEC USE ONLY</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Citizenship or Place of Organization<BR>
 Delaware</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="3" ROWSPAN="4" STYLE="text-align: center; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 0.5pt 3pt">Number of <BR>
Shares <BR>
Beneficially<BR>
 Owned by<BR>
 Each <BR>
Reporting <BR>
Person<BR>
 With:</TD>
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">5. </FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Voting Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Shared Voting Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Dispositive Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 0.5pt 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; padding: 0.5pt 3pt 0.5pt 0.5pt; vertical-align: top">Shared Dispositive Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-top: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 1.5pt 10.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">Aggregate Amount Beneficially Owned by Each Reporting Person<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Percent of Class Represented by Amount in Row (9)<BR>
 5.6%<SUP>3</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Type of Reporting Person (See Instructions)<BR>
 OO</TD></TR>
<TR>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 5%; padding: 0.5pt">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 85%; padding: 0.5pt">&nbsp;</TD></TR>
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    <TD STYLE="width: 0.25in; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">1 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.</FONT></TD></TR>

<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">2 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Consists of (i) 257,664 shares held by Venrock Healthcare Capital Partners II, L.P., (ii) 104,470 shares held by VHCP Co-Investment Holdings II, LLC, (iii) 527,720 shares held by Venrock Healthcare Capital Partners III, L.P., (iv) 52,802 shares held by VHCP Co-Investment Holdings III, LLC and (v) 622,344 shares held by Venrock Healthcare Capital Partners EG, L.P. </FONT></TD></TR>

<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">3 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">This percentage is calculated based upon 27,790,677 shares of the Issuer&#8217;s Common Stock outstanding as of November 9, 2021, as reported in the Issuer&#8217;s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 12, 2021. </FONT></TD></TR>
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    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 9 of 17</FONT></TD></TR>
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<TD STYLE="border-top: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt 3pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD COLSPAN="2" STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">1. </FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Name of reporting persons<BR>
 VHCP Management EG, LLC</TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">2.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Check the Appropriate Box if a Member of a Group (See Instructions)<BR>
 (a) <FONT STYLE="font-family: Wingdings">x</FONT><SUP>1</SUP> (b) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">SEC USE ONLY</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Citizenship or Place of Organization<BR>
 Delaware</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="3" ROWSPAN="4" STYLE="text-align: center; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 0.5pt 3pt">Number of<BR>
 Shares<BR>
 Beneficially<BR>
 Owned by <BR>
Each <BR>
Reporting<BR>
 Person <BR>
With:</TD>
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">5. </FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Voting Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Shared Voting Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Dispositive Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 0.5pt 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; padding: 0.5pt 3pt 0.5pt 0.5pt; vertical-align: top">Shared Dispositive Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-top: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 1.5pt 10.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">Aggregate Amount Beneficially Owned by Each Reporting Person<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Percent of Class Represented by Amount in Row (9)<BR>
 5.6%<SUP>3</SUP></TD></TR>
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<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Type of Reporting Person (See Instructions)<BR>
 OO</TD></TR>
<TR>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 5%; padding: 0.5pt">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 85%; padding: 0.5pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.</FONT></TD></TR>

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    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">2 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Consists of (i) 257,664 shares held by Venrock Healthcare Capital Partners II, L.P., (ii) 104,470 shares held by VHCP Co-Investment Holdings II, LLC, (iii) 527,720 shares held by Venrock Healthcare Capital Partners III, L.P., (iv) 52,802 shares held by VHCP Co-Investment Holdings III, LLC and (v) 622,344 shares held by Venrock Healthcare Capital Partners EG, L.P. </FONT></TD></TR>

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    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">3 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">This percentage is calculated based upon 27,790,677 shares of the Issuer&#8217;s Common Stock outstanding as of November 9, 2021, as reported in the Issuer&#8217;s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 12, 2021. </FONT></TD></TR>
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<TD COLSPAN="2" STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">1. </FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Name of Reporting Persons<BR>
 Shah, Nimish</TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">2.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Check the Appropriate Box if a Member of a Group (See Instructions)<BR>
 (a) <FONT STYLE="font-family: Wingdings">x</FONT><SUP>1</SUP> (b) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">SEC USE ONLY</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Citizenship or Place of Organization<BR>
 United States</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="3" ROWSPAN="4" STYLE="text-align: center; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 0.5pt 3pt">Number of<BR>
 Shares <BR>
Beneficially<BR>
 Owned by <BR>
Each <BR>
Reporting<BR>
 Person <BR>
With:</TD>
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">5. </FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Voting Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Shared Voting Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Dispositive Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 0.5pt 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; padding: 0.5pt 3pt 0.5pt 0.5pt; vertical-align: top">Shared Dispositive Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-top: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 1.5pt 10.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">Aggregate Amount Beneficially Owned by Each Reporting Person<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Percent of Class Represented by Amount in Row (9)<BR>
 5.6%<SUP>3</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Type of Reporting Person (See Instructions)<BR>
 IN</TD></TR>
<TR>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 5%; padding: 0.5pt">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 85%; padding: 0.5pt">&nbsp;</TD></TR>
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  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 0.25in; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">1 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.</FONT></TD></TR>

<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">2 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Consists of (i) 257,664 shares held by Venrock Healthcare Capital Partners II, L.P., (ii) 104,470 shares held by VHCP Co-Investment Holdings II, LLC, (iii) 527,720 shares held by Venrock Healthcare Capital Partners III, L.P., (iv) 52,802 shares held by VHCP Co-Investment Holdings III, LLC and (v) 622,344 shares held by Venrock Healthcare Capital Partners EG, L.P. </FONT></TD></TR>

<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">3 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">This percentage is calculated based upon 27,790,677 shares of the Issuer&#8217;s Common Stock outstanding as of November 9, 2021, as reported in the Issuer&#8217;s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 12, 2021. </FONT></TD></TR>
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    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 11 of 17</FONT></TD></TR>
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<TR STYLE="background-color: white">
<TD STYLE="border-top: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt 3pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD COLSPAN="2" STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; padding: 1.5pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD>
<TD STYLE="border-top: black 1.5pt solid; border-right: black 1.5pt solid; padding: 1.5pt 3pt 0.5pt 0.5pt"><FONT STYLE="font-size: 2pt">&nbsp;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">1. </FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Name of Reporting Persons<BR>
 Koh, Bong</TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">2.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Check the Appropriate Box if a Member of a Group (See Instructions)<BR>
 (a) <FONT STYLE="font-family: Wingdings">x</FONT><SUP>1</SUP> (b) <FONT STYLE="font-family: Wingdings">&uml;</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">3.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">SEC USE ONLY</FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">4.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Citizenship or Place of Organization<BR>
 United States</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="3" ROWSPAN="4" STYLE="text-align: center; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 0.5pt 3pt">Number of<BR>
 Shares <BR>
Beneficially<BR>
 Owned by <BR>
Each <BR>
Reporting<BR>
 Person <BR>
With:</TD>
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">5. </FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Voting Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">6.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Shared Voting Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 1.5pt 3pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">7.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; vertical-align: top">Sole Dispositive Power<BR>
 0</TD></TR>
<TR STYLE="background-color: white">
<TD COLSPAN="2" STYLE="border-right: Black 1.5pt solid; vertical-align: top; border-left: Black 1.5pt solid; padding: 0.5pt 2.5pt 0.5pt 3pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">8.</FONT></TD>
<TD STYLE="border-right: black 1.5pt solid; padding: 0.5pt 3pt 0.5pt 0.5pt; vertical-align: top">Shared Dispositive Power<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-top: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 1.5pt 0.5pt 1.5pt 10.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">9.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-top: black 1.5pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 1.5pt 3pt 1.5pt 0.5pt">Aggregate Amount Beneficially Owned by Each Reporting Person<BR>
 1,565,000<SUP>2</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">10.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) <FONT STYLE="font-family: Wingdings">&uml;</FONT></FONT></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">11.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Percent of Class Represented by Amount in Row (9)<BR>
 5.6%<SUP>3</SUP></TD></TR>
<TR STYLE="background-color: white">
<TD STYLE="vertical-align: top; border-left: black 1.5pt solid; padding: 0.5pt 0.5pt 1.5pt 10.5pt; border-bottom: black 1.5pt solid; font-size: 10pt"><FONT STYLE="font-size: 10pt">12.</FONT></TD>
<TD STYLE="vertical-align: bottom; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">&nbsp;</TD>
<TD COLSPAN="4" STYLE="vertical-align: top; border-bottom: black 1.5pt solid; padding: 0.5pt 3pt 1.5pt 0.5pt; border-right: black 1.5pt solid">Type of Reporting Person (See Instructions)<BR>
 IN</TD></TR>
<TR>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 5%; padding: 0.5pt">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD STYLE="width: 1%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
<TD STYLE="width: 85%; padding: 0.5pt">&nbsp;</TD></TR>
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    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, Venrock Healthcare Capital Partners EG, L.P., VHCP Management II, LLC, VHCP Management III, LLC, VHCP Management EG, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.</FONT></TD></TR>

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    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">2 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Consists of (i) 257,664 shares held by Venrock Healthcare Capital Partners II, L.P., (ii) 104,470 shares held by VHCP Co-Investment Holdings II, LLC, (iii) 527,720 shares held by Venrock Healthcare Capital Partners III, L.P., (iv) 52,802 shares held by VHCP Co-Investment Holdings III, LLC and (v) 622,344 shares held by Venrock Healthcare Capital Partners EG, L.P. </FONT></TD></TR>

<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">3 </FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">This percentage is calculated based upon 27,790,677 shares of the Issuer&#8217;s Common Stock outstanding as of November 9, 2021, as reported in the Issuer&#8217;s Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 12, 2021. </FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>




<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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  <TR STYLE="background-color: #FEFEFE">
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 12 of 17</FONT></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Introductory Note: This Schedule 13G/A is filed on behalf of Venrock
Healthcare Capital Partners II, L.P., a limited partnership organized under the laws of the State of Delaware (&#8220;VHCP II LP&#8221;),
VHCP Co-Investment Holdings II, LLC, a limited liability company organized under the laws of the State of Delaware (&#8220;VHCP Co-Investment
II&#8221;), Venrock Healthcare Capital Partners III, L.P., a limited partnership organized under the laws of the State of Delaware (&#8220;VHCP
III LP&#8221;), VHCP Co-Investment Holdings III, LLC, a limited liability company organized under the laws of the State of Delaware (&#8220;VHCP
Co-Investment III&#8221;), Venrock Healthcare Capital Partners EG, L.P., a limited partnership organized under the laws of the State of
Delaware (&#8220;VHCP EG&#8221;), VHCP Management II, LLC, a limited liability company organized under the laws of the State of Delaware
(&#8220;VHCP Management II&#8221;), VHCP Management III, LLC, a limited liability company organized under the laws of the State of Delaware
(&#8220;VHCP Management III&#8221;), VHCP Management EG, LLC, a limited liability company organized under the laws of the State of Delaware
(&#8220;VHCP Management EG&#8221; and collectively with VHCP II LP, VHCP Co-Investment II, VHCP III LP, VHCP Co-Investment III, VHCP EG,
VHCP Management II and VHCP Management III, the &#8220;Venrock Entities&#8221;), Nimish Shah (&#8220;Shah&#8221;) and Bong Koh (&#8220;Koh&#8221;)
in respect of Common Stock of aTyr Pharma, Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 1.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(a)</FONT> <FONT STYLE="font-size: 10pt">Name of Issuer</FONT></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">aTyr Pharma, Inc.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(b)</FONT> <FONT STYLE="font-size: 10pt">Address of Issuer&#8217;s Principal Executive Offices</FONT></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">3545 John Hopkins Court, Suite #250</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">San Diego, CA 92121</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>Item 2.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(a)</FONT> <FONT STYLE="font-size: 10pt">Name of Person Filing</FONT></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Venrock Healthcare Capital Partners II, L.P.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Co-Investment Holdings II, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Venrock Healthcare Capital Partners III, L.P.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Co-Investment Holdings III, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Venrock Healthcare Capital Partners EG, L.P.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Management II, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Management III, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">VHCP Management EG, LLC</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Nimish Shah</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Bong Koh</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(b)</FONT> <FONT STYLE="font-size: 10pt">Address of Principal Business Office or, if none, Residence</FONT></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="width: 11%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; width: 36%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">New York Office:</FONT></TD>
    <TD STYLE="vertical-align: top; width: 53%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Palo Alto Office:</FONT></TD></TR>
  <TR>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">7 Bryant Park</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">3340 Hillview Avenue</FONT></TD></TR>
  <TR>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">23rd Floor</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Palo Alto, CA 94304</FONT></TD></TR>
  <TR>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">New York, NY 10018</FONT></TD>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(c)</FONT> <FONT STYLE="font-size: 10pt">Citizenship</FONT></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">All of the Venrock Entities were organized in Delaware. The individuals
are both United States citizens.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: #FEFEFE">
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 13 of 17</FONT></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(d)</FONT> <FONT STYLE="font-size: 10pt">Title of Class of Securities</FONT></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Common Stock, par value $0.001 per share</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(e)</FONT> <FONT STYLE="font-size: 10pt">CUSIP Number</FONT></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">002120202</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt; width: 8%; font-size: 10pt; text-align: justify"><FONT STYLE="font-size: 10pt"><B>Item 3. </B></FONT></TD>
    <TD STYLE="padding: 0.5pt; width: 92%; font-size: 10pt; text-align: justify"><FONT STYLE="font-size: 10pt"><B>If this statement is filed pursuant to &sect;&sect;240.13d-1(b), or 240.13d-2(b) or (c), check whether the person filing is a:</B></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not applicable</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 7%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Item 4.</B></FONT></TD>
    <TD STYLE="width: 93%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Ownership</B></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(a)</FONT> <FONT STYLE="font-size: 10pt">Amount Beneficially Owned as of December 31, 2021:</FONT></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 75%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 87%; font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners II, L.P.</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Co-Investment Holdings II, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners III, L.P.</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Co-Investment Holdings III, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners EG, L.P.</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management II, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management III, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="white-space: nowrap; font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management EG, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Nimish Shah</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Bong Koh</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(b)</FONT> <FONT STYLE="font-size: 10pt">Percent of Class as of December 31, 2021:</FONT></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 75%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 87%; font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners II, L.P.</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">5.6</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Co-Investment Holdings II, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.6</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners III, L.P.</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.6</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Co-Investment Holdings III, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.6</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners EG, L.P.</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.6</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management II, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.6</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management III, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.6</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management EG, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.6</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Nimish Shah</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.6</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Bong Koh</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">5.6</TD><TD STYLE="font-size: 10pt; text-align: left">%</TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(c)
Number of shares as to which the person has, as of December 31, 2021:</FONT></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(i)</FONT> <FONT STYLE="font-size: 10pt">Sole power to vote or to direct the vote</FONT></P>


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<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 75%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 87%; font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners II, L.P.</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">0</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Co-Investment Holdings II, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners III, L.P.</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Co-Investment Holdings III, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners EG, L.P.</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management II, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management III, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management EG, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Nimish Shah</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Bong Koh</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>




<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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  <TR STYLE="background-color: #FEFEFE">
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 14 of 17</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(ii)</FONT> <FONT STYLE="font-size: 10pt">Shared power to vote or to direct the vote</FONT></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 75%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 87%; font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners II, L.P.</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Co-Investment Holdings II, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners III, L.P.</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Co-Investment Holdings III, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners EG, L.P.</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management II, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="white-space: nowrap; font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management III, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management EG, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Nimish Shah</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Bong Koh</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(iii)</FONT> <FONT STYLE="font-size: 10pt">Sole power to dispose or to direct the disposition of</FONT></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 75%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 87%; font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners II, L.P.</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">0</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Co-Investment Holdings II, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners III, L.P.</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Co-Investment Holdings III, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners EG, L.P.</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management II, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management III, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management EG, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Nimish Shah</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Bong Koh</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">0</TD><TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin-left: 0.125in; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 10pt">(iv)</FONT> <FONT STYLE="font-size: 10pt">Shared power to dispose or to direct the disposition of</FONT></P>


<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLPADDING="0" CELLSPACING="0" ALIGN="CENTER" STYLE="border-collapse: collapse; width: 75%; font: 10pt Times New Roman, Times, Serif">
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="width: 87%; font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners II, L.P.</TD><TD STYLE="width: 1%; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="width: 1%; font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="width: 10%; font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="width: 1%; font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Co-Investment Holdings II, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners III, L.P.</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="white-space: nowrap; font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Co-Investment Holdings III, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Venrock Healthcare Capital Partners EG, L.P.</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management II, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management III, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">VHCP Management EG, LLC</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: rgb(204,238,255)">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Nimish Shah</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  <TR STYLE="vertical-align: bottom; background-color: White">
    <TD STYLE="font-size: 10pt; text-align: left; text-indent: -0.25in; padding-left: 18.25pt">Bong Koh</TD><TD STYLE="font-size: 10pt">&nbsp;</TD>
    <TD STYLE="font-size: 10pt; text-align: left">&nbsp;</TD><TD STYLE="font-size: 10pt; text-align: right">1,565,000</TD><TD STYLE="font-size: 10pt; text-align: left">(1)</TD></TR>
  </TABLE>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 0.25in; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">(1)</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Consists of (i) 257,664 shares held by Venrock Healthcare Capital Partners II, L.P., (ii) 104,470 shares held by VHCP Co-Investment Holdings II, LLC, (iii) 527,720 shares held by Venrock Healthcare Capital Partners III, L.P., (iv) 52,802 shares held by VHCP Co-Investment Holdings III, LLC and (v) 622,344 shares held by Venrock Healthcare Capital Partners EG, L.P. VHCP Management II, LLC is the general partner of Venrock Healthcare Capital Partners II, L.P. and the manager of VHCP Co-Investment Holdings II, LLC. VHCP Management III, LLC is the general partner of Venrock Healthcare Capital Partners III, L.P. and the manager of VHCP Co-Investment Holdings III, LLC. VHCP Management EG, LLC is the general partner of Venrock Healthcare Capital Partners EG, L.P. Messrs. Shah and Koh are the voting members of VHCP Management II, LLC, VHCP Management III, LLC and VHCP Management EG, LLC.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: #FEFEFE">
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 15 of 17</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; width: 8%; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Item 5.</B></FONT></TD>
    <TD STYLE="padding: 0.5pt; width: 92%; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Ownership of Five Percent or Less of a Class</B></FONT></TD></TR>
  </TABLE>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">If this statement is being filed to report the fact that as of the
date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the
following <FONT STYLE="font-family: Wingdings"><FONT STYLE="font-family: Wingdings">&#168;</FONT></FONT>.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; width: 8%; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Item 6.</B></FONT></TD>
    <TD STYLE="padding: 0.5pt; width: 92%; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Ownership of More than Five Percent on Behalf of Another Person</B></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not Applicable</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; width: 8%; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Item 7.</B></FONT></TD>
    <TD STYLE="padding: 0.5pt; width: 92%; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.</B></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not Applicable</P>



<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 8%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Item 8.</B></FONT></TD>
    <TD STYLE="width: 92%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Identification and Classification of Members of the Group</B></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not Applicable</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 8%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Item 9.</B></FONT></TD>
    <TD STYLE="width: 92%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Notice of Dissolution of a Group</B></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Not Applicable</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="width: 9%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Item 10.</B></FONT></TD>
    <TD STYLE="width: 91%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Certification</B></FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the
control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction
having that purpose or effect, other than activities solely in connection with a nomination under &sect; 240.14a-11.</P>




<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"></P>

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    <DIV STYLE="margin-top: 12pt; margin-bottom: 6pt; border-bottom: Black 1pt solid"><P STYLE="text-align: left; margin-top: 0pt; margin-bottom: 0pt">&nbsp;</P></DIV>
    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 12pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="background-color: #FEFEFE">
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 16 of 17</FONT></TD></TR>
  </TABLE>

<P STYLE="margin-top: 0; margin-bottom: 0">&nbsp;</P>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0; text-align: center"><B><U>SIGNATURE</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">After reasonable inquiry and to the best of my knowledge and belief,
I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">Dated: February 14, 2022</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Venrock Healthcare Capital Partners II, L.P.</B></FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Venrock Healthcare Capital Partners III, L.P.</B></FONT></TD></TR>
  <TR>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">VHCP Management II, LLC</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">VHCP Management III, LLC</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Its:</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">General Partner</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Its:</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">General Partner</FONT></TD></TR>
  <TR>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ David L. Stepp</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ David L. Stepp</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 3%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
    <TD STYLE="width: 40%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">David L. Stepp</FONT></TD>
    <TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 3%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 5%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
    <TD STYLE="width: 40%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">David L. Stepp</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Its:</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Authorized Signatory</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Its:</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Authorized Signatory</FONT></TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>VHCP Co-Investment Holdings II, LLC</B></FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>VHCP Co-Investment Holdings III, LLC</B></FONT></TD></TR>
  <TR>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">VHCP Management II, LLC</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">VHCP Management III, LLC</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Its:</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Manager</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Its:</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Manager</FONT></TD></TR>
  <TR>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ David L. Stepp</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ David L. Stepp</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">David L. Stepp</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">David L. Stepp</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Its:</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Authorized Signatory</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Its:</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Authorized Signatory</FONT></TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="3" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>VHCP Management II, LLC</B></FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>VHCP Management III, LLC</B></FONT></TD></TR>
  <TR>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ David L. Stepp</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ David L. Stepp</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">David L. Stepp</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">David L. Stepp</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Its:</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Authorized Signatory</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Its:</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Authorized Signatory</FONT></TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Venrock Healthcare Capital Partners EG, L.P.</B></FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>VHCP Management EG, LLC</B></FONT></TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">VHCP Management EG, LLC</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ David L. Stepp</FONT></TD></TR>
  <TR>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Its:</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">General Partner</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">David L. Stepp</FONT></TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Its:</FONT></TD>
    <TD COLSPAN="2" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Authorized Signatory</FONT></TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ David L. Stepp</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Name:</FONT></TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">David L. Stepp</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Its:</FONT></TD>
    <TD COLSPAN="2" STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">Authorized Signatory</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="padding: 0.5pt">&nbsp;</TD></TR>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 10pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="vertical-align: top; width: 48%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Bong Koh</B></FONT></TD>
    <TD STYLE="width: 4%; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="width: 48%; padding: 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ David L. Stepp</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">David L. Stepp, Attorney-in-fact</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>Nimish Shah</B></FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="vertical-align: top; border-bottom: black 1pt solid; padding: 0.5pt 0.5pt 1pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">/s/ David L. Stepp</FONT></TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt">&nbsp;</TD></TR>
  <TR>
    <TD COLSPAN="3" STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">David L. Stepp, Attorney-in-fact</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>




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  <TR STYLE="background-color: #FEFEFE">
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. 002120202</B></FONT></TD>
    <TD STYLE="width: 50%; padding: 0.5pt; font-size: 10pt; text-align: right"><FONT STYLE="font-size: 10pt">Page 17 of 17</FONT></TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0"><B>EXHIBITS</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>

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    <TD STYLE="width: 0.25in; padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">A:</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">Joint Filing Agreement (incorporated by reference to Exhibit A to Schedule
13G filed September 27, 2021)</TD></TR>

<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">B:</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">Power of Attorney for Nimish Shah (incorporated by reference to Exhibit
B to Schedule 13G filed September 27, 2021)</TD></TR>

<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">&nbsp;</TD></TR>
<TR STYLE="vertical-align: top; background-color: white">
    <TD STYLE="padding: 0.5pt; font-size: 10pt"><FONT STYLE="font-size: 10pt">C:</FONT></TD>
    <TD STYLE="padding: 0.5pt; font-size: 10pt">Power of Attorney for Bong Koh (incorporated by reference to Exhibit
C to Schedule 13G filed September 27, 2021)</TD></TR>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0pt 0">&nbsp;</P>



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