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Stockholders' Equity (Tables) | 3 Months Ended
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Mar. 31, 2026
Summary of Common Stock Reserved for Future Issuance | Common Stock Reserved for Future Issuance Common stock reserved for future issuance was as follows:
|  | March 31, 2026 |
Common stock options and restricted stock units |  |  | 13,835,392 |
Shares available under the 2015 equity incentive plan |  |  | 2,305,370 |
Shares available under the 2022 inducement plan |  |  | 167,567 |
Shares available under the employee stock purchase plan |  |  | 574,212 |
|  |  | 16,882,541 |
Summary of Stock Option Activity | The following table summarizes our stock option activity under all equity incentive plans for the three months ended March 31, 2026:
|  | Number of Outstanding Stock Options |  |  | Weighted- Average Exercise Price |
Outstanding as of December 31, 2025 |  |  | 9,591,504 |  |  | $ | 3.82 |
Granted |  |  | 3,974,091 |  |  | $ | 0.71 |
Canceled/forfeited/expired |  |  | (139,607 | ) |  | $ | 12.52 |
Outstanding as of March 31, 2026 |  |  | 13,425,988 |  |  | $ | 2.81 |
Schedule of Restricted Stock Units Activity | The following table summarizes our restricted stock unit activity under all equity incentive plans for the three months ended March 31, 2026:
|  | Number of Outstanding Restricted Stock Units |  |  | Weighted-Average Grant Date Fair Value |
Balance as of December 31, 2025 |  |  | 20,108 |  |  | $ | 5.52 |
Granted |  |  | 446,940 |  |  | $ | 0.71 |
Released |  |  | (20,108 | ) |  | $ | 5.52 |
Cancelled |  |  | (37,536 | ) |  | $ | 0.71 |
Balance as of March 31, 2026 |  |  | 409,404 |  |  | $ | 0.71 |
Schedule of Allocation of Stock-Based Compensation for All Options and Restricted Stock Units and Stock Issued Pursuant to Our Employee Stock Purchase Plan | The allocation of stock-based compensation for all options and restricted stock units and stock issued pursuant to our employee stock purchase plan is as follows (in thousands):
|  | Three Months Ended March 31, |
|  | 2026 |  |  | 2025 |
Research and development |  | $ | 283 |  |  | $ | 304 |
General and administrative |  |  | 1,024 |  |  |  | 874 |
Total stock-based compensation expense |  | $ | 1,307 |  |  | $ | 1,178 |
Employee Stock Option [Member] |
Summary of Assumptions Used to Determine Fair Value of Employee Stock Option Grants and Performance Options with Market Condition | The assumptions used in the Black-Scholes option pricing model to determine the fair value of the employee stock option grants were as follows:
|  | Three Months Ended March 31,
|  | 2026 |  | 2025
Expected term (in years) |  | 5.77 – 6.08 |  | 6.02 – 6.08
Risk-free interest rate |  | 3.7% – 3.9% |  | 4.1% – 4.5%
Expected volatility |  | 105.5% – 106.7% |  | 75.9% – 77.2%
Expected dividend yield |  | 0.0% |  | 0.0%

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