<SEC-DOCUMENT>0001193125-23-149315-index.html : 20230519
<SEC-HEADER>0001193125-23-149315.hdr.sgml : 20230519
<ACCEPTANCE-DATETIME>20230519160915
ACCESSION NUMBER:		0001193125-23-149315
CONFORMED SUBMISSION TYPE:	424B5
PUBLIC DOCUMENT COUNT:		4
FILED AS OF DATE:		20230519
DATE AS OF CHANGE:		20230519

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Prelude Therapeutics Inc
		CENTRAL INDEX KEY:			0001678660
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				811384762
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		424B5
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-261019
		FILM NUMBER:		23940124

	BUSINESS ADDRESS:	
		STREET 1:		200 POWDER MILL ROAD
		CITY:			WILMINGTON
		STATE:			DE
		ZIP:			19803
		BUSINESS PHONE:		(302) 547-3768

	MAIL ADDRESS:	
		STREET 1:		200 POWDER MILL ROAD
		CITY:			WILMINGTON
		STATE:			DE
		ZIP:			19803

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Prelude Therapeutics Inc.
		DATE OF NAME CHANGE:	20160630
</SEC-HEADER>
<DOCUMENT>
<TYPE>424B5
<SEQUENCE>1
<FILENAME>d487902d424b5.htm
<DESCRIPTION>424B5
<TEXT>
Document 1 - file: d487902d424b5.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>2
<FILENAME>g487902g00q05.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 2 - file: g487902g00q05.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>3
<FILENAME>g487902g01p31.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 3 - file: g487902g01p31.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>4
<FILENAME>g487902g42h54.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 4 - file: g487902g42h54.jpg

</DOCUMENT>
</SEC-DOCUMENT>