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Segments (Tables)

3 Months Ended

Mar. 31, 2025

Segment Reporting [Abstract]

Schedule of Significant Expense Categories Reviewed by CODM

The following tables summarizes the significant expense categories regularly reviewed by the CODM for the three months ended March 31, 2025 and 2024:

		Three months ended March 31,
(in thousands)		2025				2024
Operating expenses:
Research and development
PRT3789		$	4,493			$	4,161
PRT7732			2,979				—
Discovery programs			2,468				5,190
Other			2,429				2,865
General costs, including personnel related			16,447				15,193
Total research and development			28,816				27,409
General and administrative			5,790				6,934
Total operating expenses		$	34,606			$	34,343
Loss from operations			(34,606	)			(34,343	)
Other income, net			2,521				2,912
Net loss		$	(32,085	)		$	(31,431	)

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Schedule of significant expense categories reviewed by CODM.

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