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Segments - Schedule of Significant Expense Categories Reviewed by CODM (Details) - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2025
Mar. 31, 2024
Operating expenses:    
Research and development $ 28,816 $ 27,409
General and administrative 5,790 6,934
Total operating expenses 34,606 34,343
Loss from operations (34,606) (34,343)
Other income, net 2,521 2,912
Net loss (32,085) (31,431)
PRT3789    
Operating expenses:    
Research and development 4,493 4,161
PRT7732    
Operating expenses:    
Research and development 2,979  
Discovery Programs    
Operating expenses:    
Research and development 2,468 5,190
Other    
Operating expenses:    
Research and development 2,429 2,865
General Costs, Including Personnel Related    
Operating expenses:    
Research and development $ 16,447 $ 15,193