<SEC-DOCUMENT>0000929638-25-003930.txt : 20251020
<SEC-HEADER>0000929638-25-003930.hdr.sgml : 20251020
<ACCEPTANCE-DATETIME>20251020160115
ACCESSION NUMBER:		0000929638-25-003930
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20251017
FILED AS OF DATE:		20251020
DATE AS OF CHANGE:		20251020

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Dorton Katina
		CENTRAL INDEX KEY:			0001617541
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-39527
		FILM NUMBER:		251403797

	MAIL ADDRESS:	
		STREET 1:		US ECOLOGY, INC.
		STREET 2:		251 E. FRONT ST., SUITE 400
		CITY:			BOISE
		STATE:			ID
		ZIP:			83702

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Prelude Therapeutics Inc
		CENTRAL INDEX KEY:			0001678660
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				811384762
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		175 INNOVATION BOULEVARD
		CITY:			WILMINGTON
		STATE:			DE
		ZIP:			19805
		BUSINESS PHONE:		(302) 467-1280

	MAIL ADDRESS:	
		STREET 1:		175 INNOVATION BOULEVARD
		CITY:			WILMINGTON
		STATE:			DE
		ZIP:			19805

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Prelude Therapeutics Inc.
		DATE OF NAME CHANGE:	20160630
</SEC-HEADER>
<DOCUMENT>
<TYPE>3
<SEQUENCE>1
<FILENAME>form3.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2025-10-17</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001678660</issuerCik>
        <issuerName>Prelude Therapeutics Inc</issuerName>
        <issuerTradingSymbol>PRLD</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001617541</rptOwnerCik>
            <rptOwnerName>Dorton Katina</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O PRELUDE THERAPEUTICS INCORPORATED</rptOwnerStreet1>
            <rptOwnerStreet2>175 INNOVATION BOULEVARD</rptOwnerStreet2>
            <rptOwnerCity>WILMINGTON</rptOwnerCity>
            <rptOwnerState>DE</rptOwnerState>
            <rptOwnerZipCode>19805</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>true</isDirector>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Bryant D. Lim, Attorney-in-Fact</signatureName>
        <signatureDate>2025-10-20</signatureDate>
    </ownerSignature>
</ownershipDocument>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-24
<SEQUENCE>2
<FILENAME>poa.htm
<TEXT>
<html>
  <head>
    <title></title>
    <!-- Licensed to: Morgan Lewis
         Document created using Broadridge PROfile 25.8.1.5328
         Copyright 1995 - 2025 Broadridge -->
  </head>
<body style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; text-align: left; color: #000000;" bgcolor="#ffffff">
  <div><br>
  </div>
  <div style="text-align: right;"><font style="font-weight: bold;">Exhibit 24</font><br>
  </div>
  <div>
    <div style="text-align: center; margin-top: 51.85pt; color: #000000; font-family: 'Times New Roman'; font-weight: bold;"><u>POWER OF ATTORNEY</u></div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 54pt; margin-top: 26.1pt; color: #000000; font-family: 'Times New Roman';"><font style="font-weight: bold;">KNOW ALL
        PERSONS BY THESE PRESENTS, </font>that the undersigned hereby constitutes and appoints Prelude Therapeutics Incorporated&#8217;s Chief Executive Officer, Chief Financial Officer, and the Chief Legal Officer and each of them, as their true and lawful
      attorney-in- fact to:</div>
    <div style="text-align: justify; text-indent: 72pt; margin-left: 54pt; margin-top: 13.55pt;"><font style="font-family: 'Times New Roman'; color: #000000;">(1)</font><font style="text-indent: 0px; font-size: 5.14pt;" class="TRGRRTFtoHTMLTab">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</font><font style="font-family: 'Times New Roman'; color: #000000;">execute for and on behalf of the undersigned, in the undersigned's capacity as a representative of Prelude Therapeutics
        Incorporated (the <font style="font-weight: bold; font-style: italic;">"Company"), </font>any and all Form ID, or Form 3, 4 or 5 reports and any amendments thereto required to be filed by the
        undersigned in accordance with Section 16(a) of the Securities Exchange Act of 1934 (the <font style="font-weight: bold; font-style: italic;">"Exchange Act") </font>and the rules thereunder with
        respect to transactions in the Company's securities;</font></div>
    <div style="text-align: justify; text-indent: 72pt; margin-left: 54pt; margin-top: 11.75pt;"><font style="font-family: 'Times New Roman'; color: #000000;">(2)</font><font style="text-indent: 0px; font-size: 5.14pt;" class="TRGRRTFtoHTMLTab">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</font><font style="font-family: 'Times New Roman'; color: #000000;">do and perform any and all acts for and on behalf of the undersigned which may be necessary or desirable to complete and
        execute any such Form ID, or Form 3, 4 or 5 report and any amendments thereto and timely file such report with the U.S. Securities and Exchange Commission and any stock exchange or similar authority; and</font></div>
    <div style="text-align: justify; text-indent: 72pt; margin-left: 54pt; margin-top: 12.25pt;"><font style="font-family: 'Times New Roman'; color: #000000;">(3)</font><font style="text-indent: 0px; font-size: 5.14pt;" class="TRGRRTFtoHTMLTab">&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</font><font style="font-family: 'Times New Roman'; color: #000000;">take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact,
        may be of benefit to, in the best interest of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned, pursuant to this Power of Attorney, shall be in such form
        and shall contain such terms and conditions as such attorney-in-fact may approve in his or her discretion.</font></div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 54pt; margin-top: 12.25pt; color: #000000; font-family: 'Times New Roman';">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and
      perform each and every act and thing whatsoever requisite, necessary, and proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally
      present, with full power of substitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or his or her substitute or substitutes, shall lawfully do or cause to be done by virtue of this Power of Attorney and the rights
      and powers herein granted. The undersigned acknowledges that no such attorney-in-fact, in serving in such capacity at the request of the undersigned, is hereby assuming, nor is the Company hereby assuming, any of the undersigned's responsibilities to
      comply with Section 16 of the Exchange Act.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-left: 54pt; margin-top: 12.1pt; color: #000000; font-family: 'Times New Roman';">The undersigned agrees that each such attorney-in-fact may rely entirely on information
      furnished orally or in writing by the undersigned to each such attorney-in-fact. The undersigned also agrees to indemnify and hold harmless the Company and each such attorney-in-fact against any losses, claims, damages or liabilities (or actions in
      these respects) that arise out of or are based on any untrue statement or omission of necessary facts in the information provided by the undersigned to such attorney-in-fact for purposes of executing, acknowledging, delivering and filing Forms 3, 4
      or 5 (including amendments thereto) and agrees to reimburse the Company and each such attorney-in-fact for any legal or other expenses reasonably incurred in connection with investigating or defending against any such loss, claim, damage, liability
      or action.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" class="BRPFPageBreakArea">
      <div style="page-break-after: always;" class="BRPFPageBreak">
        <hr style="margin: 4px 0px; width: 100%; border-width: 0; height: 2px; color: #000000; background-color: #000000; clear: both;" noshade="noshade"></div>
    </div>
    <div><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; margin-top: 0.1pt; color: #000000; font-family: 'Times New Roman';">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file
      Form 3, 4 or 5 reports with respect to the undersigned's holdings of and transactions in securities issued by the Company, unless earlier revoked by the undersigned in a signed writing delivered to the foregoing attorneys-in-fact.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-top: 11.8pt; margin-bottom: 25pt; color: #000000; font-family: 'Times New Roman';"><font style="font-weight: bold;">IN</font>&#160;<font style="font-weight: bold;">WITNESS WHEREOF, </font>the undersigned has executed this Power of Attorney as of the date set forth below.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-top: 11.8pt; margin-bottom: 25pt; color: rgb(0, 0, 0); font-family: 'Times New Roman'; margin-left: 324pt;">Signature:&#160; <u>/s/ Katina Dorton</u><br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; margin-top: 11.8pt; margin-bottom: 25pt; color: rgb(0, 0, 0); font-family: 'Times New Roman'; margin-left: 324pt;">Printed Name:&#160; Katina Dorton<br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; margin-top: 11.8pt; margin-bottom: 25pt; color: rgb(0, 0, 0); font-family: 'Times New Roman'; margin-left: 324pt;">Date: 14 October 2025<br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; margin-top: 11.8pt; margin-bottom: 25pt; color: #000000; font-family: 'Times New Roman';"> <br>
    </div>
    <div style="text-align: justify; text-indent: 36pt; margin-top: 11.8pt; margin-bottom: 25pt; color: #000000; font-family: 'Times New Roman';"> <br>
    </div>
    <br>
    <div><br>
    </div>
  </div>
</body>
</html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
