    <SEC-DOCUMENT>0001193125-26-191603-index.html : 20260429
    <SEC-HEADER>0001193125-26-191603.hdr.sgml : 20260429
    <ACCEPTANCE-DATETIME>20260429161323
    ACCESSION NUMBER:		0001193125-26-191603
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20251231
    FILED AS OF DATE:		20260429
    DATE AS OF CHANGE:		20260429
    EFFECTIVENESS DATE:		20260429

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Prelude Therapeutics Inc
    		CENTRAL INDEX KEY:			0001678660
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				811384762
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-39527
    		FILM NUMBER:		26916184

    	BUSINESS ADDRESS:
    		STREET 1:		175 INNOVATION BOULEVARD
    		CITY:			WILMINGTON
    		STATE:			DE
    		ZIP:			19805
    		BUSINESS PHONE:		(302) 467-1280

    	MAIL ADDRESS:
    		STREET 1:		175 INNOVATION BOULEVARD
    		CITY:			WILMINGTON
    		STATE:			DE
    		ZIP:			19805

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Prelude Therapeutics Inc.
    		DATE OF NAME CHANGE:	20160630
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>ars_4.29.26.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: ars_4.29.26.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>