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Stock Plan (Tables) | 12 Months Ended
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Dec. 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
Schedule of Stock Options Activity | The following table summarizes option activity for the year ended December 31, 2021:
|  |  |  |  |  | Options Outstanding |
|  |  |  |  |  |  |  |  |  |  |  |  |  | Weighted- Average |  |  |  |  |
|  |  |  |  |  |  |  |  |  | Weighted |  |  | Remaining |  |  | Aggregate |
|  | Shares |  |  | Number |  |  | Average |  |  | Contractual |  |  | Intrinsic |
|  | Available |  |  | of |  |  | Exercise |  |  | Life |  |  | Value |
|  | for Grant |  |  | Options |  |  | Price |  |  | (in years) |  |  | (in 000s) |
Balances, December 31, 2020 |  |  | 4,609,725 |  |  |  | 4,090,970 |  |  | $ | 3.14 |  |  |  | 7.13 |  |  | $ | 238,792 |
Shares reserved for issuance |  |  | 1,343,334 |  |  |  | – |  |  |  |  |  |  |  |  |  |  |  |  |
Options retired under 2013 Equity Plan |  |  | (237,542 | ) |  |  | – |  |  |  |  |  |  |  |  |  |  |  |  |
Options granted |  |  | (807,180 | ) |  |  | 807,180 |  |  | $ | 29.22 |  |  |  |  |  |  |  |  |
Options forfeited / cancelled |  |  | 43,343 |  |  |  | (43,343 | ) |  | $ | 6.89 |  |  |  |  |  |  |  |  |
Options exercised |  |  | – |  |  |  | (608,800 | ) |  | $ | 2.03 |  |  |  |  |  |  |  |  |
Balances, December 31, 2021 |  |  | 4,951,680 |  |  |  | 4,246,007 |  |  | $ | 8.22 |  |  |  | 6.86 |  |  | $ | 68,506 |
At December 31, 2021 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Vested and expected to vest |  |  |  |  |  |  | 4,246,007 |  |  | $ | 8.22 |  |  |  | 6.86 |  |  | $ | 68,506 |
Exercisable |  |  |  |  |  |  | 2,668,149 |  |  | $ | 3.48 |  |  |  | 5.80 |  |  | $ | 52,952 |
Schedule of Estimated Fair Value of Stock Options | The Company estimated the fair value of stock options using the Black-Scholes options valuation model. The fair value of employee stock options is being amortized on a straight-line basis over the requisite service period of the awards. The fair value of employee stock options was estimated using the following assumptions:
| Year Ended December 31, |
| 2021 |  |  | 2020 |  |  | 2019 |
Risk-free interest rate | 0.35% - 1.30% |  |  | 0.31% - 1.51% |  |  | 1.49% - 2.51% |
Expected life (in years) | 5.50 - 6.44 |  |  | 4.92 - 6.40 |  |  | 5.27 - 6.37 |
Dividend yield | 0% |  |  | 0% |  |  | 0% |
Expected volatility | 76.50% - 79.90% |  |  | 70.70% - 77.60% |  |  | 72.07% - 72.69% |
Stock-based Compensation Expense Related to Options Granted Recorded and Allocated | Stock-based compensation expense recorded under ASC 718 related to options granted was allocated to research and development and general and administrative expense as follows:
|  | For the Years Ended December 31, |
|  | 2021 |  |  | 2020 |  |  | 2019 |
Research and development |  | $ | 1,440 |  |  | $ | 836 |  |  | $ | 302 |
General and administrative |  |  | 3,900 |  |  |  | 1,097 |  |  |  | 606 |
Total stock-based compensation |  | $ | 5,340 |  |  | $ | 1,933 |  |  | $ | 908 |
2020 ESPP |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] |
Schedule of Estimated Fair Value of Stock Options | The weighted average assumptions used to estimate the fair value of stock options granted and stock purchase rights under the ESPP are as follows:
| Year Ended December 31, 2021 |
Risk-free interest rate | 0.04% |
Expected life (in years) |  | 0.50 |
Dividend yield | 0% |
Expected volatility | 77.83% |

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