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Income Taxes - Additional Information (Details) - USD ($)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Income Tax Contingency [Line Items]      
Federal statutory income tax rate 21.00% 21.00% 21.00%
Net operating loss carryforwards begin to expire in 2033 $ 27,515,000    
Net operating loss carryforwards, do not expire amount $ 132,371,000    
Net operating loss carryforward, description Net operating loss carryforwards related to tax years after 2017 of $132,371 do not expire.    
Interest or penalties accrued $ 0 $ 0  
Unrecognized tax benefits $ 1,654,000 877,000 $ 543,000
Open tax year 2013 2014 2015 2016 2017 2018 2019 2020 2021    
Federal      
Income Tax Contingency [Line Items]      
Net operating loss carryforwards $ 159,886,000 97,665,000  
Operating loss carryforwards expiration year 2033    
Tax credit carryforward, expiration 2034    
Income tax examination period 3 years    
Federal | Research and Development Tax Credits      
Income Tax Contingency [Line Items]      
Credit carryforward, amount $ 6,588,000 3,470,000  
State      
Income Tax Contingency [Line Items]      
Operating loss carryforwards expiration year 2033    
Income tax examination period 4 years    
State | New Jersey      
Income Tax Contingency [Line Items]      
Net operating loss carryforwards $ 154,972,000 92,805,000  
Tax credit carryforward, expiration 2022    
State | California      
Income Tax Contingency [Line Items]      
Net operating loss carryforwards $ 4,912,000 4,912,000  
Tax credit carryforward, expiration 2022    
State | Lexington, Massachusetts      
Income Tax Contingency [Line Items]      
Net operating loss carryforwards $ 4,640,000 $ 950,000