<SEC-DOCUMENT>0000947871-22-000432.txt : 20220401
<SEC-HEADER>0000947871-22-000432.hdr.sgml : 20220401
<ACCEPTANCE-DATETIME>20220401170657
ACCESSION NUMBER:		0000947871-22-000432
CONFORMED SUBMISSION TYPE:	SC 13D/A
PUBLIC DOCUMENT COUNT:		2
FILED AS OF DATE:		20220401
DATE AS OF CHANGE:		20220401
GROUP MEMBERS:		ORBIMED CAPITAL GP V LLC
GROUP MEMBERS:		ORBIMED CAPITAL LLC
GROUP MEMBERS:		ORBIMED GENESIS GP LLC

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			PMV Pharmaceuticals, Inc.
		CENTRAL INDEX KEY:			0001699382
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				463218129
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13D/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-91714
		FILM NUMBER:		22799290

	BUSINESS ADDRESS:	
		STREET 1:		8 CLARKE DRIVE
		CITY:			CRANBURY
		STATE:			NJ
		ZIP:			08512
		BUSINESS PHONE:		(609) 642-6664

	MAIL ADDRESS:	
		STREET 1:		8 CLARKE DRIVE
		CITY:			CRANBURY
		STATE:			NJ
		ZIP:			08512

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ORBIMED ADVISORS LLC
		CENTRAL INDEX KEY:			0001055951
		IRS NUMBER:				133976876
		STATE OF INCORPORATION:			DE

	FILING VALUES:
		FORM TYPE:		SC 13D/A

	BUSINESS ADDRESS:	
		STREET 1:		601 LEXINGTON AVENUE
		STREET 2:		54TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
		BUSINESS PHONE:		(212) 739-6400

	MAIL ADDRESS:	
		STREET 1:		601 LEXINGTON AVENUE
		STREET 2:		54TH FLOOR
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13D/A
<SEQUENCE>1
<FILENAME>ss908991_sc13da.htm
<DESCRIPTION>AMENDMENT NO. 1
<TEXT>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>

<!-- Field: Rule-Page --><DIV STYLE="margin-top: 12pt; margin-bottom: 3pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>UNITED STATES</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SECURITIES AND EXCHANGE COMMISSION</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Washington, D.C. 20549</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 16pt Times New Roman, Times, Serif; margin: 0 9.35pt 0 0; text-align: center"><B>SCHEDULE 13D</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 9.35pt 0 0; text-align: center"><B>Under the Securities Exchange Act of
1934</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 9.35pt 0 0; text-align: center"><B>(Amendment No. 1)*</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 100%; padding: 2.25pt; font: 12pt Times New Roman, Times, Serif; text-align: center"><FONT STYLE="font-size: 16pt"><B>PMV Pharmaceuticals, Inc.</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-top: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Name of Issuer)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; text-indent: 1in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>COMMON STOCK</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Title of Class of Securities)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; text-indent: 0.75in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 10pt; color: #333333; background-color: white"><B>69353Y103</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(CUSIP Number)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 1in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>OrbiMed Advisors LLC</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>OrbiMed Capital GP V LLC</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>OrbiMed Genesis GP LLC</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>OrbiMed Capital LLC</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>601 Lexington Avenue, 54th Floor</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>New York, NY 10022</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Telephone: (212) 739-6400</B></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 1in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">(Name, Address and Telephone Number of Person Authorized
    to<BR>
    Receive Notices and Communications)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; text-indent: 1in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>March 29, 2022</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 10pt">(Date of Event which Requires Filing of this Statement)</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">If the filing person has previously filed a statement on Schedule 13G to
report the acquisition that is the subject of this Schedule&nbsp;13D, and is filing this schedule because of &sect;&sect;240.13d-1(e),
240.13d-1(f) or 240.13d-1(g), check the following box.&nbsp; &#9744;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Note:</B>&nbsp; Schedules filed in paper format shall include a signed
original and five copies of the schedule, including all exhibits.&nbsp; See &sect;240.13d-7(b) for other parties to whom copies are to
be sent.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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    <TD STYLE="width: 18px; font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">*</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif"><FONT STYLE="font-size: 10pt">The remainder of this cover page shall be filled out for a Reporting Person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter disclosures provided in a prior cover page.</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">The information required on the remainder of this cover page shall not
be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the Securities Exchange Act of 1934 (&#8220;Act&#8221;) or otherwise
subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 30%; border: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 6pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No.&nbsp; <FONT STYLE="color: #333333; background-color: white">69353Y103</FONT></B></FONT></TD>
    <TD STYLE="width: 40%; padding: 6pt 6pt 1.5pt; font: 12pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 30%; padding: 6pt; font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="border-top: Black 1pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">1</FONT></TD>
    <TD COLSPAN="4" STYLE="border-top: Black 1pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Names of Reporting Persons.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">OrbiMed Advisors LLC</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">2</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Check the Appropriate Box if a Member of a Group (See Instructions).</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">(a) <FONT STYLE="font-family: Wingdings">o</FONT></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">(b) <FONT STYLE="font-family: Wingdings">o</FONT></P></TD>
    <TD STYLE="white-space: nowrap; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">3</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">SEC Use Only&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.25in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">4</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Source of Funds (See Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">AF</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">5</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Check if Disclosure of Legal Proceedings Is Required Pursuant to Items&nbsp;2(d)
    or 2(e)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.75in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">6</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Delaware</P></TD></TR>
  <TR>
    <TD COLSPAN="2" ROWSPAN="4" STYLE="border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">NUMBER OF</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">SHARES</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">BENEFICIALLY</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">OWNED BY</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">EACH</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">REPORTING</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">PERSON</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">WITH</P></TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">7</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">0</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">8</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">6,589,330</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">9</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">0</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">10</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">6,589,330</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">11</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Aggregate Amount Beneficially Owned by Each Reporting Person&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">6,589,330</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">12</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
    Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 1.5in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
    &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">13</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Percent of Class Represented by Amount in Row (11)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">14.5%*</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">14</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Type of Reporting Person (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">IA</P></TD></TR>
  <TR>
    <TD STYLE="width: 9%">&nbsp;</TD>
    <TD STYLE="width: 12%">&nbsp;</TD>
    <TD STYLE="width: 9%">&nbsp;</TD>
    <TD STYLE="width: 63%">&nbsp;</TD>
    <TD STYLE="width: 7%">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0">* This percentage is calculated based upon 45,450,699 shares of common stock
outstanding of PMV Pharmaceuticals, Inc. (the &#8220;Issuer&#8221;), as set forth in the Issuer&#8217;s Annual Report on Form 10-K filed
with the Securities and Exchange Commission (&#8220;SEC&#8221;) on March 1, 2022.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 30%; border: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 6pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. <FONT STYLE="color: #333333; background-color: white">69353Y103</FONT></B></FONT></TD>
    <TD STYLE="width: 40%; padding: 6pt 6pt 1.5pt; font: 12pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 30%; padding: 6pt; font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="border-top: Black 1pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">1</FONT></TD>
    <TD COLSPAN="4" STYLE="border-top: Black 1pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Names of Reporting Persons.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">OrbiMed Capital GP V LLC</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">2</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Check the Appropriate Box if a Member of a Group (See Instructions).</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">(a) <FONT STYLE="font-family: Wingdings">o</FONT></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">(b) <FONT STYLE="font-family: Wingdings">o</FONT></P></TD>
    <TD STYLE="white-space: nowrap; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">3</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt"><FONT STYLE="font-size: 10pt">SEC Use Only&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </FONT></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">4</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Source of Funds (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">AF</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">5</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt"><FONT STYLE="font-size: 10pt">Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </FONT></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">6</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Delaware</P></TD></TR>
  <TR>
    <TD COLSPAN="2" ROWSPAN="4" STYLE="border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">NUMBER OF</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">SHARES</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">BENEFICIALLY</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">OWNED BY</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">EACH</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">REPORTING</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">PERSON</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">WITH</P></TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">7</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">0</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">8</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">6,475,291</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">9</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">0</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">10</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">6,475,291</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">11</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Aggregate Amount Beneficially Owned by Each Reporting Person&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">6,475,291</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">12</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </FONT></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">13</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Percent of Class Represented by Amount in Row (11)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">14.2%*</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">14</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Type of Reporting Person (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">OO</P></TD></TR>
  <TR>
    <TD STYLE="width: 9%">&nbsp;</TD>
    <TD STYLE="width: 12%">&nbsp;</TD>
    <TD STYLE="width: 9%">&nbsp;</TD>
    <TD STYLE="width: 63%">&nbsp;</TD>
    <TD STYLE="width: 7%">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0">* This percentage is calculated based upon 45,450,699 shares of common stock
outstanding of PMV Pharmaceuticals, Inc. (the &#8220;Issuer&#8221;), as set forth in the Issuer&#8217;s Annual Report on Form 10-K filed
with the Securities and Exchange Commission (&#8220;SEC&#8221;) on March 1, 2022.</P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 30%; border: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 6pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. <FONT STYLE="color: #333333; background-color: white">69353Y103</FONT></B></FONT></TD>
    <TD STYLE="width: 40%; padding: 6pt 6pt 1.5pt; font: 12pt Times New Roman, Times, Serif; text-align: center">&nbsp;</TD>
    <TD STYLE="width: 30%; padding: 6pt; font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR>
    <TD STYLE="border-top: Black 1pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">1</FONT></TD>
    <TD COLSPAN="4" STYLE="border-top: Black 1pt solid; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Names of Reporting Persons.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">OrbiMed Genesis GP LLC</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">2</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Check the Appropriate Box if a Member of a Group (See Instructions).</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">(a) <FONT STYLE="font-family: Wingdings">o</FONT></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">(b) <FONT STYLE="font-family: Wingdings">o</FONT></P></TD>
    <TD STYLE="white-space: nowrap; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">3</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt"><FONT STYLE="font-size: 10pt">SEC Use Only&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </FONT></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">4</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Source of Funds (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">AF</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">5</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt"><FONT STYLE="font-size: 10pt">Check if Disclosure of Legal Proceedings Is Required Pursuant to Items 2(d) or 2(e)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </FONT></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">6</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Delaware</P></TD></TR>
  <TR>
    <TD COLSPAN="2" ROWSPAN="4" STYLE="border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">NUMBER OF</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">SHARES</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">BENEFICIALLY</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">OWNED BY</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">EACH</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">REPORTING</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">PERSON</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">WITH</P></TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">7</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">0</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">8</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">114,039</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">9</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">0</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">10</FONT></TD>
    <TD COLSPAN="2" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">114,039</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">11</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Aggregate Amount Beneficially Owned by Each Reporting Person&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">114,039</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">12</FONT></TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt"><FONT STYLE="font-size: 10pt">Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </FONT></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">13</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Percent of Class Represented by Amount in Row (11)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">0.3%*</P></TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">14</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Type of Reporting Person (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">OO</P></TD></TR>
  <TR>
    <TD STYLE="width: 9%">&nbsp;</TD>
    <TD STYLE="width: 12%">&nbsp;</TD>
    <TD STYLE="width: 9%">&nbsp;</TD>
    <TD STYLE="width: 63%">&nbsp;</TD>
    <TD STYLE="width: 7%">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0">* This percentage is calculated based upon 45,450,699 shares of common stock
outstanding of PMV Pharmaceuticals, Inc. (the &#8220;Issuer&#8221;), as set forth in the Issuer&#8217;s Annual Report on Form 10-K filed
with the Securities and Exchange Commission (&#8220;SEC&#8221;) on March 1, 2022.</P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;&nbsp;</P>

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<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD COLSPAN="4" STYLE="border: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 6pt"><FONT STYLE="font-size: 10pt"><B>CUSIP No. <FONT STYLE="color: #333333; background-color: white">69353Y103</FONT></B></FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif; padding: 6pt 6pt 1.5pt; text-align: center">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="font: 12pt Times New Roman, Times, Serif; padding: 6pt">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt">&nbsp;</TD>
    <TD STYLE="border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt">&nbsp;</TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">1</FONT></TD>
    <TD COLSPAN="6" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Names of Reporting Persons.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">OrbiMed Capital LLC</P></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">2</FONT></TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Check the Appropriate Box if a Member of a Group (See Instructions).</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">(a) <FONT STYLE="font-family: Wingdings">o</FONT></P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">(b) <FONT STYLE="font-family: Wingdings">o</FONT></P></TD>
    <TD STYLE="white-space: nowrap; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">3</FONT></TD>
    <TD COLSPAN="6" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt"><FONT STYLE="font-size: 10pt">SEC Use Only&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; </FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">4</FONT></TD>
    <TD COLSPAN="6" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Source of Funds (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">AF</P></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">5</FONT></TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Check if Disclosure of Legal Proceedings Is Required Pursuant to Items
    2(d) or 2(e)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.75in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">6</FONT></TD>
    <TD COLSPAN="6" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Citizenship or Place of Organization&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Cayman Islands</P></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD COLSPAN="2" ROWSPAN="4" STYLE="border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">NUMBER OF</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">SHARES</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">BENEFICIALLY</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">OWNED BY</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">EACH</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">REPORTING</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">PERSON</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">WITH</P></TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">7</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Sole Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">266,093</P></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">8</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Shared Voting Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">0</P></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">9</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Sole Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">266,093</P></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">10</FONT></TD>
    <TD COLSPAN="4" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Shared Dispositive Power&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">0</P></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">11</FONT></TD>
    <TD COLSPAN="6" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Aggregate Amount Beneficially Owned by Each Reporting Person&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">266,093</P></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">12</FONT></TD>
    <TD COLSPAN="5" STYLE="border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Check if the Aggregate Amount in Row (11) Excludes Certain Shares (See
    Instructions)</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P></TD>
    <TD STYLE="vertical-align: top; border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-family: Wingdings; font-size: 10pt">o</FONT></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">13</FONT></TD>
    <TD COLSPAN="6" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Percent of Class Represented by Amount in Row (11)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">0.6%*</P></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 2.25pt; text-align: center"><FONT STYLE="font-size: 14pt">14</FONT></TD>
    <TD COLSPAN="6" STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; padding: 2.25pt">
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Type of Reporting Person (See Instructions)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">IA</P></TD>
    <TD STYLE="font: 12pt Times New Roman, Times, Serif">&nbsp;</TD></TR>
  <TR>
    <TD STYLE="width: 7%">&nbsp;</TD>
    <TD STYLE="width: 12%">&nbsp;</TD>
    <TD STYLE="width: 7%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="width: 48%">&nbsp;</TD>
    <TD STYLE="width: 19%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 1%">&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 8pt Times New Roman, Times, Serif; margin: 0">* This percentage is calculated based upon 45,450,699 shares of common stock
outstanding of PMV Pharmaceuticals, Inc. (the &#8220;Issuer&#8221;), as set forth in the Issuer&#8217;s Annual Report on Form 10-K filed
with the Securities and Exchange Commission (&#8220;SEC&#8221;) on March 1, 2022.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 10pt 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Item 1.&nbsp; Security and Issuer</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">This Amendment No. 1 to Schedule
13D (the &#8220;<U>Statement</U>&#8221;) supplements and amends the Statement on Schedule 13D of OrbiMed Advisors LLC, OrbiMed Capital
GP V LLC, OrbiMed Genesis GP LLC and OrbiMed Capital LLC originally filed with the Securities and Exchange Commission (the &#8220;<U>SEC</U>&#8221;)
on October 5, 2020 (the &#8220;<U>Statement</U>&#8221;). This Statement relates to the common stock, par <FONT STYLE="background-color: white">value
$.00001 per share</FONT> (the &#8220;<U>Shares</U>&#8221;) of PMV Pharmaceuticals, Inc., <FONT STYLE="background-color: white">a corporation
organized under the laws of Delaware</FONT> (the &#8220;<U>Issuer</U>&#8221; ), with its principal executive offices located at 8 Clarke
Drive, Suite 3, Cranbury, New Jersey 08512. The Shares are listed on the NASDAQ Global Select Market under the ticker symbol &#8220;PMVP&#8221;.
Information given in response to each item shall be deemed incorporated by reference in all other items, as applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">This Amendment No. 1 is being
filed to report that the beneficial ownership of the outstanding Shares held by the Reporting Persons was reduced by more than 1% since
the filing of the Statement following the transactions described in Item 5(c) below. Further, as a result of the transactions described
in Item 5(c) below, OrbiMed Partners Master Fund Limited (&#8220;<U>OPM</U>&#8221;) no longer holds any Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Item 2. Identity and Background</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">(a) This Schedule 13D is being
filed by OrbiMed Advisors LLC (&#8220;<U>OrbiMed Advisors</U>&#8221;), OrbiMed Capital GP V LLC (&#8220;<U>OrbiMed GP</U>&#8221;), OrbiMed
Genesis GP LLC (&#8220;<U>OrbiMed Genesis</U>&#8221;), and OrbiMed Capital LLC (&#8220;<U>OrbiMed Capital</U>&#8221;) (collectively, the
&#8220;<U>Reporting Persons</U>&#8221;).</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;(b) &#8212; (c), (f) OrbiMed
Advisors, a limited liability company organized under the laws of Delaware and a registered investment adviser under the Investment Advisers
Act of 1940, as amended, is the managing member or general partner of certain entities as more particularly described in Item 6 below.&nbsp;
OrbiMed Advisors has its principal offices at 601 Lexington Avenue, 54th Floor, New York, New York 10022.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">OrbiMed GP, a limited liability
company organized under the laws of Delaware, is the general partner of a limited partnership as more particularly described in Item 6
below.&nbsp; OrbiMed GP has its principal offices at 601 Lexington Avenue, 54th Floor, New York, New York 10022.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">OrbiMed Genesis, a limited liability
company organized under the laws of Delaware, is the general partner of a limited partnership as more particularly described in Item 6
below.&nbsp; OrbiMed Genesis has its principal offices at 601 Lexington Avenue, 54th Floor, New York, New York 10022.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">OrbiMed Capital, a limited liability
company organized under the laws of Delaware and a registered investment adviser under the Investment Advisers Act of 1940, as amended,
is the investment adviser of certain entities as more particularly described in Item 6 below.&nbsp; OrbiMed Capital has its principal
offices at 601 Lexington Avenue, 54th Floor, New York, New York 10022.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">The directors and executive officers
of OrbiMed Advisors, OrbiMed Capital, OrbiMed GP, and OrbiMed Genesis are set forth on Schedules I, II, III, and IV, respectively, attached
hereto.&nbsp; Schedules I, II, III and IV set forth the following information with respect to each such person:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">(i)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;name;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">(ii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;business
address;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">(iii)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;present
principal occupation of employment and the name, principal business and address of any corporation or other organization in which such
employment is conducted; and</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">(iv)&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;citizenship.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">(d) &#8212; (e) During the last
five years, neither the Reporting Persons nor any Person named in Schedules I through IV has been (i) convicted in a criminal proceeding
(excluding traffic violations or similar misdemeanors) or (ii) a party to a civil proceeding of a judicial or administrative body of competent
jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of,
or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B></B></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Item 3.&nbsp; Source and Amount of Funds or Other Consideration</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 20pt; background-color: white">Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Item 4.&nbsp; Purpose of Transaction</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">The Shares were initially acquired
by the Reporting Persons for the purpose of making an investment in the Issuer and not with the intention of acquiring control of the
Issuer&#8217;s business on behalf of the Reporting Persons&#8217; respective advisory clients.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">The Reporting Persons from time
to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer&#8217;s business, financial
condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those
for the Issuer&#8217;s Shares in particular, as well as other developments and other investment opportunities.&nbsp; Based upon such review,
the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances
existing from time to time.&nbsp; If the Reporting Persons believe that further investment in the Issuer is attractive, whether because
of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either in the open market or in
privately negotiated transactions.&nbsp; Similarly, depending on market and other factors, the Reporting Persons may determine to dispose
of some or all of the Shares currently owned by the Reporting Persons or otherwise acquired by the Reporting Persons either in the open
market or in privately negotiated transactions.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">Except as set forth in this Schedule
13D, the Reporting Persons have not formulated any plans or proposals which relate to or would result in:&nbsp; (a) the acquisition by
any person of additional securities of the Issuer or the disposition of securities of the Issuer, (b) an extraordinary corporate transaction,
such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries, (c) a sale or transfer of a material
amount of the assets of the Issuer or any of its subsidiaries, (d) any change in the present Board of Directors or management of the Issuer,
including any plans or proposals to change the number or term of directors or to fill any existing vacancies on the board, (e) any material
change in the Issuer&#8217;s capitalization or dividend policy of the Issuer, (f) any other material change in the Issuer&#8217;s business
or corporate structure, (g) any change in the Issuer&#8217;s charter or bylaws or other instrument corresponding thereto or other action
which may impede the acquisition of control of the Issuer by any person, (h) causing a class of the Issuer&#8217;s securities to be deregistered
or delisted from a national securities exchange or to cease to be authorized to be quoted in an inter-dealer quotation system of a registered
national securities association, (i) a class of equity securities of the Issuer becoming eligible for termination of registration pursuant
to Section 12(g)(4) of the Act or (j) any action similar to any of those enumerated above.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Item 5.&nbsp; Interest in Securities of the Issuer</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;(a) &#8212; (b) The following
disclosure is based upon 45,450,699 outstanding Shares of the Issuer, as set forth in the Issuer&#8217;s Annual Report on Form 10-K filed
the SEC on March 1, 2022.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">As of the date of this filing,
OrbiMed Private Investments V, LP (&#8220;<U>OPI V</U>&#8221;), a limited partnership organized under the laws of Delaware, holds 6,475,291
Shares, constituting approximately 14.2% of the issued and outstanding Shares.&nbsp; OrbiMed GP is the general partner of OPI V, pursuant
to the terms of the limited partnership agreement of OPI V, and OrbiMed Advisors is the managing member of OrbiMed GP, pursuant to the
terms of the limited liability company agreement of OrbiMed GP.&nbsp; As a result, OrbiMed Advisors and OrbiMed GP share power to direct
the vote and disposition of the Shares held by OPI V and may be deemed directly or indirectly, including by reason of their mutual affiliation,
to be the beneficial owners of the Shares held by OPI V.&nbsp; OrbiMed Advisors exercises this investment and voting power through a management
committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the Shares held
by OPI VI.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">In addition, OrbiMed Advisors
and OrbiMed GP, pursuant to their authority under the limited partnership agreement of OPI V, caused OPI V to enter into the agreements
referred to in Item 6 below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">As of the date of this filing,
OrbiMed Genesis Master Fund, L.P. (&#8220;<U>Genesis</U>&#8221;), a limited partnership organized under the laws of the Cayman Islands,
holds 114,039 Shares constituting approximately 0.3% of the issued and outstanding Shares.&nbsp; OrbiMed Genesis is the general partner
of Genesis, pursuant to the terms of the limited partnership agreement of Genesis, and OrbiMed Advisors is the managing member of OrbiMed
Genesis, pursuant to the terms of the limited liability company agreement of OrbiMed Genesis.&nbsp; As a result, OrbiMed Advisors and
OrbiMed Genesis share power to direct the vote and disposition of the Shares held by Genesis and may be deemed, directly or indirectly,
including by reason of their mutual affiliation, to be the beneficial owners of the Shares held by Genesis.&nbsp;OrbiMed Advisors exercises
this investment and voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho and W. Carter Neild, each of
whom disclaims beneficial ownership of the Shares held by Genesis.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">In addition, OrbiMed Advisors
and OrbiMed Genesis, pursuant to their authority under the limited partnership agreement of Genesis, caused Genesis to enter into the
agreements referred to in Item 6 below.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">As of the date of this filing,
the Biotech Growth Trust PLC (&#8220;<U>BIOG</U>&#8221;), a publicly-listed investment trust organized under the laws of England, holds
266,093 Shares constituting approximately 0.6% of the issued and outstanding Shares.&nbsp; OrbiMed Capital is the investment advisor of
BIOG. As a result, OrbiMed Capital has the power to direct the vote and disposition of the Shares held by BIOG and may be deemed directly
or indirectly, including by reason of mutual affiliation, to be the beneficial owner of the Shares held by BIOG.&nbsp; OrbiMed Capital
disclaims any beneficial ownership over the shares of the other Reporting Persons.&nbsp; OrbiMed Capital exercises this investment and
voting power through a management committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial
ownership of the Shares held by BIOG.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">As of March 31, 2022, OPM, an
exempted company organized under the laws of Bermuda, no longer holds any Shares. OrbiMed Capital is the investment advisor of OPM. As
a result, OrbiMed Capital has the power to direct the vote and disposition of the Shares held by OPM and may be deemed directly or indirectly,
including by reason of mutual affiliation, to be the beneficial owner of the Shares held by OPM. OrbiMed Capital disclaims any beneficial
ownership over the shares of the other Reporting Persons. OrbiMed Capital exercises this investment and voting power through a management
committee comprised of Carl L. Gordon, Sven H. Borho, and W. Carter Neild, each of whom disclaims beneficial ownership of the Shares held
by OPM.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">(c)</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="width: 17%; border: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Seller</B></FONT></TD>
    <TD STYLE="width: 23%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Date of Transaction</B></FONT></TD>
    <TD STYLE="width: 20%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Transaction</B></FONT></TD>
    <TD STYLE="width: 20%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Number of Shares</B></FONT></TD>
    <TD STYLE="width: 20%; border-top: Black 1pt solid; border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt"><B>Price Per Share</B></FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">OPM</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">March 29, 2022</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">Sold</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">365,000</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">$21.52</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">OPM</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">March 30, 2022</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">Sold</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">75,000</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">$22.39</FONT></TD></TR>
  <TR STYLE="vertical-align: bottom">
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; border-left: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">OPM</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">March 31, 2022</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">Sold</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">34,500</FONT></TD>
    <TD STYLE="border-right: Black 1pt solid; border-bottom: Black 1pt solid; font: 12pt Times New Roman, Times, Serif; padding-right: 5.4pt; padding-left: 5.4pt; text-align: center"><FONT STYLE="font-size: 10pt">$21.17</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">(d) Not applicable.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">(e) Not applicable.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Item 6.&nbsp; Contracts, Arrangements, Understandings or Relationships
with Respect to Securities of the Issuer</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">In addition to the relationships
between the Reporting Persons described in Items 2 and 5 above, OrbiMed GP is the general partner of OPI V, pursuant to the terms of the
limited partnership agreement of OPI V.&nbsp; Pursuant to this agreement and relationship, OrbiMed GP has discretionary investment management
authority with respect to the assets of OPI V. Such authority includes the power to vote and otherwise dispose of securities held by OPI
V.&nbsp; The number of outstanding Shares of the Issuer attributable to OPI V is 6,475,291 Shares. OrbiMed GP, pursuant to its authority
under the limited partnership agreement of OPI VI, may be considered to hold indirectly 6,475,291 Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">OrbiMed Genesis is the general
partner of Genesis, pursuant to the terms of the limited partnership agreement of Genesis.&nbsp; Pursuant to this agreement and relationship,
OrbiMed Genesis has discretionary investment management authority with respect to the assets of Genesis. Such authority includes the power
to vote and otherwise dispose of securities held by Genesis.&nbsp; The number of outstanding Shares of the Issuer attributable to Genesis
is 114,039. OrbiMed Genesis, pursuant to its authority under the limited partnership agreement of Genesis, may be considered to hold indirectly
114,039 Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">OrbiMed Advisors is the managing
member of OrbiMed GP and OrbiMed Genesis, pursuant to the terms of the limited liability company agreements of OrbiMed GP and OrbiMed
Genesis. Pursuant to these agreements and relationships, OrbiMed Advisors and OrbiMed GP have discretionary investment management authority
with respect to the assets of OPI V.&nbsp; OrbiMed Advisors and OrbiMed Genesis have discretionary investment management authority with
respect to the assets of Genesis. Such authority includes the power of OrbiMed GP to vote and otherwise dispose of securities held by
OPI V and the power of OrbiMed Genesis to vote and otherwise dispose of the securities held by Genesis.&nbsp; The number of outstanding
Shares attributable to OPI V is 6,475,291 Shares and the number of Shares attributed to Genesis is 114,039 Shares.&nbsp; OrbiMed Advisors,
pursuant to its authority under the terms of the limited liability company agreements of OrbiMed GP and OrbiMed Genesis, may also be considered
to hold indirectly 6,589,330&nbsp;Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in">OrbiMed Capital is the investment
advisor to BIOG. OrbiMed Capital may be deemed to have voting and investment power over the securities held by BIOG. Such authority includes
the power of OrbiMed Capital to vote and otherwise dispose of securities held by BIOG.&nbsp; The number of outstanding Shares attributable
to BIOG is 266,093 Shares. OrbiMed Capital, as the investment advisor to BIOG, may also be considered to hold indirectly 266,093 Shares.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; background-color: white"><B><I>Investors&#8217; Rights Agreement</I></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 10pt 0 0; text-align: justify; text-indent: 20.15pt">In addition, OPI V, BIOG,
Genesis, and certain other stockholders of the Issuer entered into an Amended and Restated Investors&#8217; Rights Agreement with the
Issuer (the &#8220;<U>Investors&#8217; Rights Agreement</U>&#8221;), dated as of July 17, 2020. Pursuant to the Investors&#8217; Rights
Agreement and subject to the terms and conditions therein, the parties agreed that:</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; background-color: white"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; background-color: white"><I>Demand Registration Rights</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.25in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.25in; background-color: white">At any
time beginning six months following the date of the effective date of the registration statement of the Issuer&#8217;s initial public
offering, the holders of at least 30% of the registrable securities then outstanding of the Issuer may make a written request that the
Issuer register some or all of their registrable securities, subject to certain specified conditions and exceptions, including that the
aggregated gross offering price of such offering must exceed $5 million. The Issuer is required to use commercially reasonable efforts
to effect the registration and will pay all registration expenses, other than underwriting discounts and commissions, related to any demand
registration. The Issuer is not obligated to effect more than two of these registrations.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; background-color: white"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; background-color: white"><I>Piggyback Registration
Rights</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; background-color: white"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.25in; background-color: white"><FONT STYLE="background-color: white">Whenever
the Issuer proposes to file a registration statement under the Securities Act, including a registration statement on Form&nbsp;S-3&nbsp;as
discussed below, other than with respect to certain excluded registrations, OPI V, BIOG, and Genesis will be entitled to notice of the
registration and have the right, subject to limitations that the underwriters may impose on the number of Shares included in the registration,
to include the Shares held by them in the registration.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.25in; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; background-color: white"><I>Form S-3 Registration
Rights</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; background-color: white"><I>&nbsp;</I></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.25in; background-color: white">At any
time after the Issuer is qualified to file a registration statement on Form S-3 under the Securities Act, and subject to limitations and
conditions specified in the Investors&#8217; Rights Agreement, holders of at least 30% of the registrable securities then outstanding
may make a written request that the Issuer prepare and file a registration statement on Form S-3 covering their Shares, so long as the
aggregate price to the public equal or exceeds $5 million. The Issuer is not obligated to effect more than two of these Form S-3 registrations
in any 12-month period.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.25in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.25in"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.25in">The foregoing description of
the Investors&#8217; Rights Agreement does not purport to be complete and is qualified in its entirety by reference to the full text of
the Investors&#8217; Rights Agreement, which is filed as Exhibits 2 and incorporated herein by reference.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>Item 7.&nbsp; Material to Be Filed as Exhibits</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 12%; border-top: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 4.5pt"><FONT STYLE="font-size: 10pt"><B>Exhibit</B></FONT></TD>
    <TD STYLE="width: 88%; border: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 4.5pt"><FONT STYLE="font-size: 10pt"><B>Description</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 4.5pt"><FONT STYLE="font-size: 10pt">1.</FONT></TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 4.5pt"><FONT STYLE="font-size: 10pt">Joint Filing Agreement among OrbiMed Advisors LLC, OrbiMed Capital LLC, OrbiMed Genesis GP LLC, and OrbiMed Capital GP V LLC.</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 4.5pt"><FONT STYLE="font-size: 10pt">2.</FONT></TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; font: 12pt Times New Roman, Times, Serif; padding: 4.5pt"><FONT STYLE="font-size: 10pt">Amended and Restated Investors&#8217; Rights Agreement by and among the Issuer and each of the signatories thereto, dated as of July 17, 2020 (incorporated by reference to Exhibit 4.1 to the Issuer&#8217;s Registration Statement on Form S-1 (SEC 333-248627), filed with the SEC on September 4, 2020).</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B></B></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>Signature</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">After reasonable inquiry and to the best of my knowledge
and belief, I certify that the information set forth in this statement is true, complete and correct.</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 12pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD><FONT STYLE="font-size: 10pt">Dated: April 1, 2022</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">ORBIMED ADVISORS LLC</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 52%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 33%">&nbsp;</TD>
    <TD STYLE="width: 10%">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Carl L. Gordon&#9;</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Name: Carl L. Gordon</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Title: Member </FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">ORBIMED CAPITAL GP V LLC</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">ORBIMED ADVISORS LLC, its managing member</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Carl L. Gordon&#9;</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Name: Carl L. Gordon</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Title: Member of OrbiMed Advisors LLC</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">ORBIMED GENESIS GP LLC</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">ORBIMED ADVISORS LLC, it&#8217;s managing member</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Carl L. Gordon&#9;&#9;</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Name: Carl L. Gordon</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Title: Member of OrbiMed Advisors LLC</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">ORBIMED CAPITAL LLC</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Carl L. Gordon&#9;&#9;</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Name: Carl L. Gordon</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Title: Member </FONT></TD>
    <TD>&nbsp;</TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0 0 3.25in"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B>&nbsp;</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SCHEDULE I</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0.05in; text-align: justify; text-indent: 0.45in"><FONT STYLE="font-size: 10pt">The
names and present principal occupations of each of the executive officers and directors of OrbiMed Advisors LLC are set forth below. Unless
otherwise noted, each of these persons is a United States citizen and has a business address of 601 Lexington Avenue, 54</FONT><FONT STYLE="font-size: 8pt">th</FONT>
<FONT STYLE="font-size: 10pt">Floor, New York, NY 10022.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0.05in; text-align: justify; text-indent: 0.45in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 12pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 34%; padding-right: 0.25in; text-align: center"><FONT STYLE="font-size: 10pt"><U>Name</U></FONT></TD>
    <TD STYLE="width: 33%; padding-right: 0.25in; text-align: center"><FONT STYLE="font-size: 10pt"><U>Position with Reporting Person</U></FONT></TD>
    <TD STYLE="width: 33%; padding-right: 0.25in; text-align: center"><FONT STYLE="font-size: 10pt"><U>Principal Occupation</U></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Carl L. Gordon</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Advisors LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Sven H. Borho</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">German and Swedish Citizen</P></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Advisors LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">W. Carter Neild</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Advisors LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Geoffrey C. Hsu</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Advisors LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">C. Scotland Stevens</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Advisors LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">David P. Bonita</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Advisors LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Peter A. Thompson</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Advisors LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Matthew S. Rizzo</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Advisors LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Trey Block</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Chief Financial Officer</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Chief Financial Officer</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Advisors LLC</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B></B></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SCHEDULE II</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0.05in; text-align: justify; text-indent: 0.45in"><FONT STYLE="font-size: 10pt">The
names and present principal occupations of each of the executive officers and directors of OrbiMed Capital LLC are set forth below. Unless
otherwise noted, each of these persons is a United States citizen and has a business address of 601 Lexington Avenue, 54</FONT><FONT STYLE="font-size: 8pt">th</FONT>
<FONT STYLE="font-size: 10pt">Floor, New York, NY 10022.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0.05in; text-align: justify; text-indent: 0.45in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 12pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 34%; padding-right: 0.25in; text-align: center"><FONT STYLE="font-size: 10pt"><U>Name</U></FONT></TD>
    <TD STYLE="width: 33%; padding-right: 0.25in; text-align: center"><FONT STYLE="font-size: 10pt"><U>Position with Reporting Person</U></FONT></TD>
    <TD STYLE="width: 33%; padding-right: 0.25in; text-align: center"><FONT STYLE="font-size: 10pt"><U>Principal Occupation</U></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Carl L. Gordon</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Capital LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Sven H. Borho</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">German and Swedish Citizen</P></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Capital LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">W. Carter Neild</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Capital LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Geoffrey C. Hsu</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Capital LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">C. Scotland Stevens</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Capital LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">David P. Bonita</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Capital LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Peter A. Thompson</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Capital LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Matthew S. Rizzo</FONT></TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Member</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Member</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Capital LLC</P></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD>
    <TD STYLE="padding-right: 0.25in; text-align: justify">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="padding-right: 0.25in; text-align: justify"><FONT STYLE="font-size: 10pt">Trey Block</FONT></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Chief Financial Officer</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P></TD>
    <TD>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">Chief Financial Officer</P>
    <P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0; text-align: justify">OrbiMed Capital LLC</P></TD></TR>
  </TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B></B></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SCHEDULE III</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0.05in; text-align: justify; text-indent: 0.45in">The business
and operations of OrbiMed Capital GP V LLC are managed by the executive officers and directors of its managing member, OrbiMed Advisors
LLC, set forth in Schedule I attached hereto.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0.05in; text-align: justify; text-indent: 0.45in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0.05in; text-align: justify; text-indent: 0.45in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0.05in; text-align: justify; text-indent: 0.45in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0.05in; text-align: justify; text-indent: 0.45in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0.05in; text-align: justify; text-indent: 0.45in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 0.05in; text-align: justify; text-indent: 0.45in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"></P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>SCHEDULE IV</B>&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0 0.25in 0 4.5pt; text-align: justify; text-indent: 31.5pt">The business and
operations of OrbiMed Genesis GP LLC are managed by the executive officers and directors of its managing member, OrbiMed Advisors LLC,
set forth in Schedule I attached hereto.</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

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    <DIV STYLE="break-before: page; margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
    <!-- Field: /Page -->

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center"><B>EXHIBIT INDEX</B></P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 12pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 12%; border-top: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 4.5pt"><FONT STYLE="font-size: 10pt"><B>Exhibit</B></FONT></TD>
    <TD STYLE="width: 88%; border: black 1.5pt solid; padding: 4.5pt"><FONT STYLE="font-size: 10pt"><B>Description</B></FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 4.5pt"><FONT STYLE="font-size: 10pt">1.</FONT></TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 4.5pt"><FONT STYLE="font-size: 10pt">Joint Filing Agreement among OrbiMed Advisors LLC, OrbiMed Capital LLC, OrbiMed Genesis GP LLC, and OrbiMed Capital GP V LLC.</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 4.5pt"><FONT STYLE="font-size: 10pt">2.</FONT></TD>
    <TD STYLE="border-right: black 1.5pt solid; border-bottom: black 1.5pt solid; border-left: black 1.5pt solid; padding: 4.5pt"><FONT STYLE="font-size: 10pt">Amended and Restated Investors&#8217; Rights Agreement by and among the Issuer and each of the persons listed on Schedule A thereto, dated as of August 21, 2020 (incorporated by reference to Exhibit 4.1 to the Issuer&#8217;s Registration Statement on Form S-1 (SEC 333-248628), filed with the SEC on September 4, 2020).</FONT></TD></TR>
  </TABLE>
<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 12pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: right">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: right"></P>

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    <DIV STYLE="margin-top: 6pt; margin-bottom: 6pt"><P STYLE="margin: 0pt">&nbsp;</P></DIV>
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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: right"></P>


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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>ss908991_ex9901.htm
<DESCRIPTION>JOINT FILING AGREEMENT
<TEXT>
<HTML>
<HEAD>
     <TITLE></TITLE>
</HEAD>
<BODY STYLE="font: 10pt Times New Roman, Times, Serif">

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: right"><B><U>Exhibit 1</U></B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center">JOINT FILING AGREEMENT</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.75in">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: justify; text-indent: 0.5in"><FONT STYLE="background-color: white">The
undersigned hereby agree that the Statement on Schedule&nbsp;13D, dated March 29, 2022, with respect to the ordinary shares of PMV Pharmaceuticals,
Inc. is filed on behalf of each of us pursuant to and in accordance with the provisions of Rule&nbsp;13d-1(k) under the Securities Exchange
Act of 1934, as amended. Each of the undersigned agrees to be responsible for the timely filing of this Statement, and for the completeness
and accuracy of the information concerning itself contained therein. This Agreement may be executed in any number of counterparts, all
of which taken together shall constitute one and the same instrument.</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;&nbsp;&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">Dated: April 1, 2022</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-indent: 0.5in">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 12pt Times New Roman, Times, Serif; width: 100%; border-collapse: collapse">
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">ORBIMED ADVISORS LLC</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD STYLE="width: 52%">&nbsp;</TD>
    <TD STYLE="width: 5%">&nbsp;</TD>
    <TD STYLE="width: 33%">&nbsp;</TD>
    <TD STYLE="width: 10%">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Carl L. Gordon<U>&#9;</U></FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Name: Carl L. Gordon</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Title: Member </FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">ORBIMED CAPITAL GP V LLC</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">ORBIMED ADVISORS LLC, its managing member</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Carl L. Gordon&#9;</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Name: Carl L. Gordon</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Title: Member of OrbiMed Advisors LLC</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">ORBIMED GENESIS GP LLC</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">ORBIMED ADVISORS LLC, it&#8217;s managing member</FONT></TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">&nbsp;</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Carl L. Gordon&#9;&#9;</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Name: Carl L. Gordon</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Title: Member of OrbiMed Advisors LLC</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD COLSPAN="2"><FONT STYLE="font-size: 10pt">ORBIMED CAPITAL LLC</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">By:</FONT></TD>
    <TD STYLE="border-bottom: Black 1pt solid"><FONT STYLE="font-size: 10pt">/s/ Carl L. Gordon&#9;&#9;</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Name: Carl L. Gordon</FONT></TD>
    <TD>&nbsp;</TD></TR>
  <TR STYLE="vertical-align: top">
    <TD>&nbsp;</TD>
    <TD>&nbsp;</TD>
    <TD><FONT STYLE="font-size: 10pt">Title: Member </FONT></TD>
    <TD>&nbsp;</TD></TR>
  </TABLE>
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