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Pay vs Performance Disclosure - USD ($) |  | 12 Months Ended
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Aug. 13, 2024 | Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Pay vs Performance Disclosure |  |  |  |
Pay vs Performance Disclosure, Table |  | Pay Versus Performance The following table sets forth compensation information for our chief executive officer, referred to below as our PEO, and our other named executive officers, or NEOs, for purposes of comparing their compensation to the value of our shareholders’ investments and our net income (loss), calculated in accordance with SEC regulations, for fiscal years 2024, 2023, and 2022:
Year |  |  | Summary Compensation Table (“SCT”) Total for PEO(1)(2) |  |  | Compensation Actually Paid (“CAP”) to PEO(1)(3) |  |  | Average SCT Total for Non-PEO Named Executive Officers (“NEOs”)(2)(4) |  |  | Average CAP to Non-PEO NEOs(3)(4) |  |  | Value of Initial Fixed $100 Investment Based on: Total Shareholder Return (“TSR”) |  |  | Net Loss (in thousands)
2024 |  |  | $4,760,281 |  |  | $2,166,091 |  |  | $1,654,265 |  |  | $1,011,546 |  |  | $6.54 |  |  | $(58,709)
2023 |  |  | $2,209,795 |  |  | $513,651 |  |  | $1,178,729 |  |  | $399,137 |  |  | $13.42 |  |  | $(68,960)
2022 |  |  | $3,576,440 |  |  | $(519,251) |  |  | $2,129,278 |  |  | $(599,868) |  |  | $37.66 |  |  | $(73,317)
(1) | For each year shown, the PEO was David H. Mack, Ph.D., our President and Chief Executive Officer. Please see the section titled “Executive Compensation—Summary Compensation Table” for additional information.
(2) | Amounts in this column represent the “Total” column set forth in the SCT. Please see the footnotes to the SCT for further detail regarding the amounts in these columns.
(3) | The dollar amounts reported in these columns represent the amounts of “compensation actually paid.” The amounts are computed in accordance with Item 402(v) of Regulation S-K by deducting and adding the amounts in the following reconciliation tables from the “Total” column of the SCT (pursuant to SEC rules, fair value at each measurement date is computed in a manner consistent with the fair value methodology used to account for share-based payments in our financial statements under GAAP).
(4) | Non-PEO NEOs reflect the average SCT total compensation and average CAP for the following executives by fiscal year:
2024: Deepika Jalota, Pharm.D. and Michael Carulli 2023: Winston Kung and Deepika Jalota, Pharm.D. 2022: Leila Alland, M.D. and Winston Kung
PEO SCT Total to CAP Reconciliation |  |  | 2024 |  |  | 2023 |  |  | 2022
SCT Total Compensation |  |  | $4,760,281 |  |  | $2,209,795 |  |  | $3,576,440
SCT Option and Stock Awards(1) |  |  | (3,817,215) |  |  | (1,328,712) |  |  | (2,814,415)
Year End Fair Value of Outstanding and Unvested Equity Awards Granted in the Year |  |  | 757,593 |  |  | 520,378 |  |  | 881,664
Change in Fair Value of Existing Unvested Equity Awards(2) |  |  | 308,858 |  |  | (714,199) |  |  | (1,907,525)
Change in Fair Value of Vested Equity Awards |  |  | (5,425) |  |  | (330,487) |  |  | (658,894)
Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year |  |  | 161,999 |  |  | 156,876 |  |  | 403,479
Compensation Actually Paid to PEO |  |  | $2,166,091 |  |  | $513,651 |  |  | $(519,251)
(1) | Represents the grant fair value of the equity awards to our PEO, as reported in the SCT.
(2) | In August 2024, in connection with the Company offering of a one-time voluntary stock option exchange to its employees, stock options held by our CEO and Non-CEO NEOs were exchanged for new stock options with an exercise price equal to $1.48 per share and a new vesting schedule (“Option Exchange”), with all other terms remaining the same. As there had been no exercises of any of the previous stock options as of the date of the Option Exchange, both vested and unvested options were exchanged 1-for-1 for the new unvested stock options which had a vesting commencement date in September 2024. For purposes of calculating compensation actually paid, shown in the table above, the incremental change in fair value recognized related to the Option Exchange is reflected in this row.
NEOs SCT Total to CAP Reconciliation |  |  | 2024 |  |  | 2023 |  |  | 2022
SCT Total Compensation |  |  | $1,654,265 |  |  | $1,178,729 |  |  | $2,129,278
SCT Option Awards(1) |  |  | (1,068,682) |  |  | (553,630) |  |  | (1,177,183)
Year End Fair Value of Outstanding and Unvested Equity Awards Granted in the Year |  |  | 345,034 |  |  | 153,264 |  |  | 595,843
Change in Fair Value of Existing Unvested Equity Awards(2) |  |  | 41,003 |  |  | (294,421) |  |  | (1,621,768)
Change in Fair Value of Vested Equity Awards |  |  | (27,022) |  |  | (150,170) |  |  | (694,801)
Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year |  |  | 66,948 |  |  | 65,365 |  |  | 168,763
Compensation Actually Paid to NEOs |  |  | $1,011,546 |  |  | $399,137 |  |  | $(599,868)
(1) | Represents the grant fair value of the equity awards to our NEOs, as reported in the SCT.
(2) | In August 2024, in connection with the Company offering of a one-time voluntary stock option exchange to its employees, stock options held by our CEO and Non-CEO NEOs were exchanged for new stock options with an exercise price equal to $1.48 per share and a new vesting schedule (“Option Exchange”), with all other terms remaining the same. The incremental change in fair value related to the Option Exchange is reflected within this row.
Named Executive Officers, Footnote |  |
(1) | For each year shown, the PEO was David H. Mack, Ph.D., our President and Chief Executive Officer. Please see the section titled “Executive Compensation—Summary Compensation Table” for additional information.
(4) | Non-PEO NEOs reflect the average SCT total compensation and average CAP for the following executives by fiscal year:
2024: Deepika Jalota, Pharm.D. and Michael Carulli 2023: Winston Kung and Deepika Jalota, Pharm.D. 2022: Leila Alland, M.D. and Winston Kung |  |
PEO Total Compensation Amount |  | $ 4,760,281 | $ 2,209,795 | $ 3,576,440
PEO Actually Paid Compensation Amount |  | $ 2,166,091 | 513,651 | (519,251)
Adjustment To PEO Compensation, Footnote |  |
PEO SCT Total to CAP Reconciliation |  |  | 2024 |  |  | 2023 |  |  | 2022
SCT Total Compensation |  |  | $4,760,281 |  |  | $2,209,795 |  |  | $3,576,440
SCT Option and Stock Awards(1) |  |  | (3,817,215) |  |  | (1,328,712) |  |  | (2,814,415)
Year End Fair Value of Outstanding and Unvested Equity Awards Granted in the Year |  |  | 757,593 |  |  | 520,378 |  |  | 881,664
Change in Fair Value of Existing Unvested Equity Awards(2) |  |  | 308,858 |  |  | (714,199) |  |  | (1,907,525)
Change in Fair Value of Vested Equity Awards |  |  | (5,425) |  |  | (330,487) |  |  | (658,894)
Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year |  |  | 161,999 |  |  | 156,876 |  |  | 403,479
Compensation Actually Paid to PEO |  |  | $2,166,091 |  |  | $513,651 |  |  | $(519,251)
(1) | Represents the grant fair value of the equity awards to our PEO, as reported in the SCT.
(2) | In August 2024, in connection with the Company offering of a one-time voluntary stock option exchange to its employees, stock options held by our CEO and Non-CEO NEOs were exchanged for new stock options with an exercise price equal to $1.48 per share and a new vesting schedule (“Option Exchange”), with all other terms remaining the same. As there had been no exercises of any of the previous stock options as of the date of the Option Exchange, both vested and unvested options were exchanged 1-for-1 for the new unvested stock options which had a vesting commencement date in September 2024. For purposes of calculating compensation actually paid, shown in the table above, the incremental change in fair value recognized related to the Option Exchange is reflected in this row.
Non-PEO NEO Average Total Compensation Amount |  | $ 1,654,265 | 1,178,729 | 2,129,278
Non-PEO NEO Average Compensation Actually Paid Amount |  | $ 1,011,546 | 399,137 | (599,868)
Adjustment to Non-PEO NEO Compensation Footnote |  |
NEOs SCT Total to CAP Reconciliation |  |  | 2024 |  |  | 2023 |  |  | 2022
SCT Total Compensation |  |  | $1,654,265 |  |  | $1,178,729 |  |  | $2,129,278
SCT Option Awards(1) |  |  | (1,068,682) |  |  | (553,630) |  |  | (1,177,183)
Year End Fair Value of Outstanding and Unvested Equity Awards Granted in the Year |  |  | 345,034 |  |  | 153,264 |  |  | 595,843
Change in Fair Value of Existing Unvested Equity Awards(2) |  |  | 41,003 |  |  | (294,421) |  |  | (1,621,768)
Change in Fair Value of Vested Equity Awards |  |  | (27,022) |  |  | (150,170) |  |  | (694,801)
Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year |  |  | 66,948 |  |  | 65,365 |  |  | 168,763
Compensation Actually Paid to NEOs |  |  | $1,011,546 |  |  | $399,137 |  |  | $(599,868)
(1) | Represents the grant fair value of the equity awards to our NEOs, as reported in the SCT.
(2) | In August 2024, in connection with the Company offering of a one-time voluntary stock option exchange to its employees, stock options held by our CEO and Non-CEO NEOs were exchanged for new stock options with an exercise price equal to $1.48 per share and a new vesting schedule (“Option Exchange”), with all other terms remaining the same. The incremental change in fair value related to the Option Exchange is reflected within this row.
Compensation Actually Paid vs. Total Shareholder Return |  |  |  |
Compensation Actually Paid vs. Net Income |  |  |  |
Total Shareholder Return Amount |  | $ 6.54 | 13.42 | 37.66
Net Income (Loss) |  | $ (58,709,000) | $ (68,960,000) | $ (73,317,000)
PEO Name |  | David H. Mack, Ph.D. | David H. Mack, Ph.D. | David H. Mack, Ph.D.
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price | $ 1.48 |  |  |
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period | 0 |  |  |
Exchange ratio of stock options for each new stock option | 1-for-1 |  |  |
PEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount |  | $ (3,817,215) | $ (1,328,712) | $ (2,814,415)
PEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount |  | 757,593 | 520,378 | 881,664
PEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount |  | 308,858 | (714,199) | (1,907,525)
PEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount |  | 161,999 | 156,876 | 403,479
PEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount |  | (5,425) | (330,487) | (658,894)
Non-PEO NEO | Aggregate Grant Date Fair Value of Equity Award Amounts Reported in Summary Compensation Table |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount |  | (1,068,682) | (553,630) | (1,177,183)
Non-PEO NEO | Year-end Fair Value of Equity Awards Granted in Covered Year that are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount |  | 345,034 | 153,264 | 595,843
Non-PEO NEO | Year-over-Year Change in Fair Value of Equity Awards Granted in Prior Years That are Outstanding and Unvested |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount |  | 41,003 | (294,421) | (1,621,768)
Non-PEO NEO | Vesting Date Fair Value of Equity Awards Granted and Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount |  | 66,948 | 65,365 | 168,763
Non-PEO NEO | Change in Fair Value as of Vesting Date of Prior Year Equity Awards Vested in Covered Year |  |  |  |
Pay vs Performance Disclosure |  |  |  |
Adjustment to Compensation, Amount |  | $ (27,022) | $ (150,170) | $ (694,801)

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