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Commitment and Contingencies - Additional Information (Detail) - USD ($)
1 Months Ended 3 Months Ended
Apr. 30, 2017
Feb. 28, 2017
Mar. 31, 2019
Mar. 31, 2018
Dec. 31, 2018
Contingencies And Commitments [Line Items]          
Research and development expense     $ 5,655,000 $ 4,744,000  
Sponsored Research Agreement [Member]          
Contingencies And Commitments [Line Items]          
Purchase commitment, amount $ 499,000        
Purchase commitment, period 3 years        
Research and development expense     42,000 $ 42,000  
Non-cancelable purchase commitments amount     181,000    
Non-cancelable purchase commitments amount, 2019     125,000    
Non-cancelable purchase commitments amount, 2020     56,000    
Indemnification Agreements [Member]          
Contingencies And Commitments [Line Items]          
Accrued liabilities     0   $ 0
Adimab Option Agreement [Member]          
Contingencies And Commitments [Line Items]          
Milestone payments   $ 25,000,000      
Option fee   $ 250,000      
Contract Manufacturing Organizations Agreement [Member]          
Contingencies And Commitments [Line Items]          
Non-cancelable purchase commitments amount     $ 250,000   $ 250,000