<SEC-DOCUMENT>0001178913-21-000595.txt : 20210216
<SEC-HEADER>0001178913-21-000595.hdr.sgml : 20210216
<ACCEPTANCE-DATETIME>20210216085544
ACCESSION NUMBER:		0001178913-21-000595
CONFORMED SUBMISSION TYPE:	SC 13G/A
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20210216
DATE AS OF CHANGE:		20210216
GROUP MEMBERS:		MOSHE ARKIN
GROUP MEMBERS:		SPHERA GLOBAL HEALTHCARE GP LTD.
GROUP MEMBERS:		SPHERA GLOBAL HEALTHCARE MANAGEMENT LP

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			X4 Pharmaceuticals, Inc
		CENTRAL INDEX KEY:			0001501697
		STANDARD INDUSTRIAL CLASSIFICATION:	BIOLOGICAL PRODUCTS (NO DIAGNOSTIC SUBSTANCES) [2836]
		IRS NUMBER:				273181608
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		SC 13G/A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	005-90199
		FILM NUMBER:		21633021

	BUSINESS ADDRESS:	
		STREET 1:		61 NORTH BEACON STREET
		STREET 2:		4TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02134
		BUSINESS PHONE:		857-529-8300

	MAIL ADDRESS:	
		STREET 1:		61 NORTH BEACON STREET
		STREET 2:		4TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02134

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Arsanis, Inc.
		DATE OF NAME CHANGE:	20100920

FILED BY:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			SPHERA FUNDS MANAGEMENT LTD.
		CENTRAL INDEX KEY:			0001496201
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			L3

	FILING VALUES:
		FORM TYPE:		SC 13G/A

	BUSINESS ADDRESS:	
		STREET 1:		21 HA'ARBA'AH STREET
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			64739
		BUSINESS PHONE:		972-3-6845535

	MAIL ADDRESS:	
		STREET 1:		21 HA'ARBA'AH STREET
		CITY:			TEL AVIV
		STATE:			L3
		ZIP:			64739
</SEC-HEADER>
<DOCUMENT>
<TYPE>SC 13G/A
<SEQUENCE>1
<FILENAME>zk2125590.htm
<DESCRIPTION>SC 13G/A
<TEXT>
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    <div style="text-align: center; line-height: 1.25; font-weight: bold;">UNITED STATES</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold; font-size: 14pt;">SECURITIES AND EXCHANGE COMMISSION</div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">Washington, D.C.&#160; 20549</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold; font-size: 14pt;">SCHEDULE 13G</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;(Amendment No. 2)*</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25; font-size: 16pt; font-weight: bold;"><u>X4 Pharmaceuticals, Inc.</u></div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">(Name of Issuer)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;"><u>Common Stock, $0.001 par value</u></div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;(Title of Class of Securities)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
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    <div style="text-align: center; line-height: 1.25;"><u>98420X103</u></div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">&#160;(CUSIP Number)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: center; line-height: 1.25;"><u>December 31, 2020</u></div>
    <div style="text-align: center; line-height: 1.25; font-weight: bold;">(Date of Event Which Requires Filing of this Statement)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">Check the appropriate box to designate the rule pursuant to which this Schedule is filed:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 28.35pt; line-height: 1.25;">&#9744; Rule 13d-1(b)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 28.35pt; line-height: 1.25;">&#9746; Rule 13d-1(c)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 28.35pt; line-height: 1.25;">&#9744; Rule 13d-1(d)</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">*The remainder of this cover page shall be filled out for a reporting person&#8217;s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing
      information which would alter the disclosures provided in a prior cover page.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">The information required in the remainder of this cover page shall not be deemed to be &#8220;filed&#8221; for the purpose of Section 18 of the <font style="font-style: italic;">Securities Exchange Act</font>
      of 1934 (&#8220;Act&#8221;) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).</div>
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              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 36.54%" colspan="4">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">CUSIP No. 98420X103</div>
              </td>
              <td style="VERTICAL-ALIGN: top; WIDTH: 35.42%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">13G</div>
              </td>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 28.04%">
                <div style="font-weight: bold; text-align: left; line-height: 1.25;">Page 2 of 11 Pages</div>
              </td>
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              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">1</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">NAME OF REPORTING PERSONS</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">Moshe Arkin</div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">2</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP&#160;&#160; (See instructions)</div>
                <div style="text-align: left; margin-left: 299.35pt; line-height: 1.25; margin-right: 30pt; text-indent: -290.6pt;">(a)&#160;&#160;&#9744;</div>
                <div style="text-align: left; margin-left: 299.35pt; line-height: 1.25; margin-right: 30pt; text-indent: -290.6pt;">(b)&#160; &#9746;</div>
              </td>
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              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">3</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%; BACKGROUND-COLOR: #aaaaaa">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SEC USE ONLY</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">4</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">Israel</div>
              </td>
            </tr>
            <tr>
              <td colspan="2" rowspan="4" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 17.36%">
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">NUMBER OF</div>
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">SHARES</div>
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">BENEFICIALLY</div>
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">OWNED BY</div>
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">EACH</div>
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">REPORTING</div>
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">PERSON WITH</div>
              </td>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.9%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">5</div>
              </td>
              <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 76.73%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SOLE VOTING POWER</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">---</div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 11.81%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">6</div>
              </td>
              <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 54.59%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SHARED VOTING POWER</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">---</div>
                        </div>
                      </div>
                    </div>
                  </div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 11.81%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">7</div>
              </td>
              <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 54.59%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SOLE DISPOSITIVE POWER</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">---</div>
              </td>
            </tr>
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              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 11.81%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">8</div>
              </td>
              <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 54.59%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SHARED DISPOSITIVE POWER</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">---</div>
                        </div>
                      </div>
                    </div>
                  </div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">9</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">---</div>
                        </div>
                      </div>
                    </div>
                  </div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">10</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)</div>
                <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 30pt">&#160;</div>
                <div style="LINE-HEIGHT: 1.25">&#9744;</div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">11</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">0.00% (*)</div>
                        </div>
                      </div>
                    </div>
                  </div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">12</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">TYPE OF REPORTING PERSON&#160;&#160; (See instructions)</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                IN</td>
            </tr>

        </table>
        <div style="LINE-HEIGHT: 1.25"><br style="LINE-HEIGHT: 1.25">
        </div>
      </div>
    </div>
    <div style="line-height: 1.25;">(*) Reflects updated holdings as of the date of this filing. The beneficial ownership of the securities reported herein is described in Item 4(a).</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">2</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="text-align: center; line-height: 1.25; font-weight: bold;">
        <table cellspacing="0" cellpadding="2" border="0" style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; BORDER-COLLAPSE: collapse; WIDTH: 100%">

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                <div style="font-family: 'Times New Roman',Times,serif; font-weight: bold; text-align: center; line-height: 1.25;">
                  <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold; line-height: 1.25;">CUSIP No. 98420X103</div>
                </div>
              </td>
              <td style="VERTICAL-ALIGN: top; WIDTH: 35.42%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">13G</div>
              </td>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 28.04%">
                <div style="font-weight: bold; text-align: left; line-height: 1.25;">Page 3 of 11 Pages</div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">1</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">NAME OF REPORTING PERSONS</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">Sphera Funds Management Ltd.</div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">2</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP&#160;&#160; (See instructions)</div>
                <div style="text-align: left; margin-left: 299.35pt; line-height: 1.25; margin-right: 30pt; text-indent: -290.6pt;">(a)&#160; &#9744;</div>
                <div style="text-align: left; margin-left: 299.35pt; line-height: 1.25; margin-right: 30pt; text-indent: -290.6pt;">(b)&#160; &#9746;</div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">3</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%; BACKGROUND-COLOR: #aaaaaa">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SEC USE ONLY</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">4</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">Israel</div>
              </td>
            </tr>
            <tr>
              <td colspan="2" rowspan="4" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 17.36%">
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">NUMBER OF</div>
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">SHARES</div>
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">BENEFICIALLY</div>
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">OWNED BY</div>
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">EACH</div>
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">REPORTING</div>
                <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">PERSON WITH</div>
              </td>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.9%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">5</div>
              </td>
              <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 76.73%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SOLE VOTING POWER</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">---</div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 11.81%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">6</div>
              </td>
              <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 54.59%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SHARED VOTING POWER</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">250,000 (*)</div>
                        </div>
                      </div>
                    </div>
                  </div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 11.81%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">7</div>
              </td>
              <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 54.59%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SOLE DISPOSITIVE POWER</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">---</div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 11.81%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">8</div>
              </td>
              <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 54.59%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SHARED DISPOSITIVE POWER</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="LINE-HEIGHT: 1.25">
                  <div style="text-align: left; line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">250,000 (*)</div>
                        </div>
                      </div>
                    </div>
                  </div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">9</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">250,000 (*)</div>
                        </div>
                      </div>
                    </div>
                  </div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">10</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)</div>
                <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 30pt">&#160;</div>
                <div style="LINE-HEIGHT: 1.25">&#9744;</div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">11</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                  <div style="line-height: 1.25;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">1.51% (*) (**)</div>
                        </div>
                      </div>
                    </div>
                  </div>
                </div>
              </td>
            </tr>
            <tr>
              <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                <div style="font-weight: bold; text-align: center; line-height: 1.25;">12</div>
              </td>
              <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">TYPE OF REPORTING PERSON&#160;&#160; (See instructions)</div>
                <div style="LINE-HEIGHT: 1.25">&#160;</div>
                <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CO</div>
              </td>
            </tr>

        </table>
        <div style="LINE-HEIGHT: 1.25"><br style="LINE-HEIGHT: 1.25">
        </div>
      </div>
    </div>
    <div style="line-height: 1.25;">(*) Reflects updated holdings as of the date of this filing. The beneficial ownership of the securities reported herein is described in Item 4(a).</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">(**) Based on (i) 16,286,645 shares of Common Stock outstanding as of November 2, 2020 (as provided in the Issuer's Form 10-Q filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on
        November 5, 2020) and (ii) certain warrants held by the Reporting Persons that are currently exercisable into shares of Common Stock.</div>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">3</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">
        <div style="text-align: center; line-height: 1.25; font-weight: bold;">
          <table cellspacing="0" cellpadding="2" border="0" style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; BORDER-COLLAPSE: collapse; WIDTH: 100%">

              <tr>
                <td colspan="4" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 36.54%">
                  <div style="font-family: 'Times New Roman',Times,serif; font-weight: bold; text-align: center; line-height: 1.25;">
                    <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold; line-height: 1.25;">CUSIP No. 98420X103</div>
                  </div>
                </td>
                <td style="VERTICAL-ALIGN: top; WIDTH: 35.42%">
                  <div style="font-weight: bold; text-align: center; line-height: 1.25;">13G</div>
                </td>
                <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 28.04%">
                  <div style="font-weight: bold; text-align: left; line-height: 1.25;">Page 4 of 11 Pages</div>
                </td>
              </tr>
              <tr>
                <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                  <div style="font-weight: bold; text-align: center; line-height: 1.25;">1</div>
                </td>
                <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">NAME OF REPORTING PERSONS</div>
                  <div style="LINE-HEIGHT: 1.25">&#160;</div>
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                    <div style="line-height: 1.25; margin-right: 30pt;">Sphera Global Healthcare GP Ltd.</div>
                  </div>
                </td>
              </tr>
              <tr>
                <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                  <div style="font-weight: bold; text-align: center; line-height: 1.25;">2</div>
                </td>
                <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP&#160;&#160; (See instructions)</div>
                  <div style="text-align: left; margin-left: 299.35pt; line-height: 1.25; margin-right: 30pt; text-indent: -290.6pt;">(a)&#160; &#9744;</div>
                  <div style="text-align: left; margin-left: 299.35pt; line-height: 1.25; margin-right: 30pt; text-indent: -290.6pt;">(b)&#160; &#9746;</div>
                </td>
              </tr>
              <tr>
                <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                  <div style="font-weight: bold; text-align: center; line-height: 1.25;">3</div>
                </td>
                <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%; BACKGROUND-COLOR: #aaaaaa">
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SEC USE ONLY</div>
                  <div style="LINE-HEIGHT: 1.25">&#160;</div>
                  <div style="LINE-HEIGHT: 1.25">&#160;</div>
                </td>
              </tr>
              <tr>
                <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                  <div style="font-weight: bold; text-align: center; line-height: 1.25;">4</div>
                </td>
                <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
                  <div style="LINE-HEIGHT: 1.25">&#160;</div>
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">Israel</div>
                </td>
              </tr>
              <tr>
                <td colspan="2" rowspan="4" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 17.36%">
                  <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">NUMBER OF</div>
                  <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">SHARES</div>
                  <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">BENEFICIALLY</div>
                  <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">OWNED BY</div>
                  <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">EACH</div>
                  <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">REPORTING</div>
                  <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">PERSON WITH</div>
                </td>
                <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.9%">
                  <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">5</div>
                </td>
                <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 76.73%">
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SOLE VOTING POWER</div>
                  <div style="LINE-HEIGHT: 1.25">&#160;</div>
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">---</div>
                </td>
              </tr>
              <tr>
                <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 11.81%">
                  <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">6</div>
                </td>
                <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 54.59%">
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SHARED VOTING POWER</div>
                  <div style="LINE-HEIGHT: 1.25">&#160;</div>
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">
                            <div style="line-height: 1.25;">&#160;250,000 (*)</div>
                          </div>
                        </div>
                      </div>
                    </div>
                  </div>
                </td>
              </tr>
              <tr>
                <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 11.81%">
                  <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">7</div>
                </td>
                <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 54.59%">
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SOLE DISPOSITIVE POWER</div>
                  <div style="LINE-HEIGHT: 1.25">&#160;</div>
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">---</div>
                </td>
              </tr>
              <tr>
                <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 11.81%">
                  <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">8</div>
                </td>
                <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 54.59%">
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SHARED DISPOSITIVE POWER</div>
                  <div style="LINE-HEIGHT: 1.25">&#160;</div>
                  <div style="LINE-HEIGHT: 1.25">
                    <div style="text-align: left; line-height: 1.25;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">
                            <div style="line-height: 1.25;">
                              <div style="line-height: 1.25; margin-right: 30pt;">
                                <div style="line-height: 1.25;">
                                  <div style="line-height: 1.25;">
                                    <div style="line-height: 1.25;">
                                      <div style="line-height: 1.25;">
                                        <div style="line-height: 1.25;">&#160;250,000 (*)</div>
                                      </div>
                                    </div>
                                  </div>
                                </div>
                              </div>
                            </div>
                          </div>
                        </div>
                      </div>
                    </div>
                  </div>
                </td>
              </tr>
              <tr>
                <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                  <div style="font-weight: bold; text-align: center; line-height: 1.25;">9</div>
                </td>
                <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
                  <div style="LINE-HEIGHT: 1.25">&#160;</div>
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">
                            <div style="line-height: 1.25; margin-right: 30pt;">
                              <div style="line-height: 1.25;">
                                <div style="line-height: 1.25;">
                                  <div style="line-height: 1.25;">
                                    <div style="line-height: 1.25;">
                                      <div style="line-height: 1.25;">&#160;250,000 (*)</div>
                                    </div>
                                  </div>
                                </div>
                              </div>
                            </div>
                          </div>
                        </div>
                      </div>
                    </div>
                  </div>
                </td>
              </tr>
              <tr>
                <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                  <div style="font-weight: bold; text-align: center; line-height: 1.25;">10</div>
                </td>
                <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)</div>
                  <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 30pt">&#160;</div>
                  <div style="LINE-HEIGHT: 1.25">&#9744;</div>
                </td>
              </tr>
              <tr>
                <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                  <div style="font-weight: bold; text-align: center; line-height: 1.25;">11</div>
                </td>
                <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9</div>
                  <div style="LINE-HEIGHT: 1.25">&#160;</div>
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                    <div style="line-height: 1.25;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">
                            <div style="line-height: 1.25;">1.51% (*) (**)</div>
                          </div>
                        </div>
                      </div>
                    </div>
                  </div>
                </td>
              </tr>
              <tr>
                <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                  <div style="font-weight: bold; text-align: center; line-height: 1.25;">12</div>
                </td>
                <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">TYPE OF REPORTING PERSON&#160;&#160; (See instructions)</div>
                  <div style="LINE-HEIGHT: 1.25">&#160;</div>
                  <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CO</div>
                </td>
              </tr>

          </table>
          <div style="LINE-HEIGHT: 1.25"><br style="LINE-HEIGHT: 1.25">
          </div>
        </div>
      </div>
    </div>
    <div style="line-height: 1.25;"></div>
    <div style="line-height: 1.25;">(*) Reflects updated holdings as of the date of this filing. The beneficial ownership of the securities reported herein is described in Item 4(a).</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">(**) Based on (i) 16,286,645 shares of Common Stock outstanding as of November 2, 2020 (as provided in the Issuer's Form 10-Q filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on
        November 5, 2020) and (ii) certain warrants held by the Reporting Persons that are currently exercisable into shares of Common Stock.</div>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">4</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;">
          <div style="text-align: center; line-height: 1.25; font-weight: bold;">
            <table cellspacing="0" cellpadding="2" border="0" style="FONT-SIZE: 10pt; FONT-FAMILY: 'Times New Roman', Times, serif; BORDER-COLLAPSE: collapse; WIDTH: 100%">

                <tr>
                  <td colspan="4" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 36.54%">
                    <div style="font-family: 'Times New Roman',Times,serif; font-weight: bold; text-align: center; line-height: 1.25;">
                      <div style="font-family: 'Times New Roman', Times, serif; font-weight: bold; line-height: 1.25;">CUSIP No. 98420X103</div>
                    </div>
                  </td>
                  <td style="VERTICAL-ALIGN: top; WIDTH: 35.42%">
                    <div style="font-weight: bold; text-align: center; line-height: 1.25;">13G</div>
                  </td>
                  <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 28.04%">
                    <div style="font-weight: bold; text-align: left; line-height: 1.25;">Page 5 of 11 Pages</div>
                  </td>
                </tr>
                <tr>
                  <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                    <div style="font-weight: bold; text-align: center; line-height: 1.25;">1</div>
                  </td>
                  <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">NAME OF REPORTING PERSONS</div>
                    <div style="LINE-HEIGHT: 1.25">&#160;</div>
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                      <div style="line-height: 1.25; margin-right: 30pt;">
                        <div style="line-height: 1.25; margin-right: 30pt;">Sphera Global Healthcare Management LP</div>
                      </div>
                    </div>
                  </td>
                </tr>
                <tr>
                  <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                    <div style="font-weight: bold; text-align: center; line-height: 1.25;">2</div>
                  </td>
                  <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP&#160;&#160; (See instructions)</div>
                    <div style="text-align: left; margin-left: 299.35pt; line-height: 1.25; margin-right: 30pt; text-indent: -290.6pt;">(a)&#160; &#9744;</div>
                    <div style="text-align: left; margin-left: 299.35pt; line-height: 1.25; margin-right: 30pt; text-indent: -290.6pt;">(b)&#160; &#9746;</div>
                  </td>
                </tr>
                <tr>
                  <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                    <div style="font-weight: bold; text-align: center; line-height: 1.25;">3</div>
                  </td>
                  <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%; BACKGROUND-COLOR: #aaaaaa">
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SEC USE ONLY</div>
                    <div style="LINE-HEIGHT: 1.25">&#160;</div>
                    <div style="LINE-HEIGHT: 1.25">&#160;</div>
                  </td>
                </tr>
                <tr>
                  <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                    <div style="font-weight: bold; text-align: center; line-height: 1.25;">4</div>
                  </td>
                  <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CITIZENSHIP OR PLACE OF ORGANIZATION</div>
                    <div style="LINE-HEIGHT: 1.25">&#160;</div>
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">Israel</div>
                  </td>
                </tr>
                <tr>
                  <td colspan="2" rowspan="4" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: middle; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 17.36%">
                    <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">NUMBER OF</div>
                    <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">SHARES</div>
                    <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">BENEFICIALLY</div>
                    <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">OWNED BY</div>
                    <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">EACH</div>
                    <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">REPORTING</div>
                    <div style="text-align: center; line-height: 1.25; margin-right: 15.9pt;">PERSON WITH</div>
                  </td>
                  <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.9%">
                    <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">5</div>
                  </td>
                  <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 76.73%">
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SOLE VOTING POWER</div>
                    <div style="LINE-HEIGHT: 1.25">&#160;</div>
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">---</div>
                  </td>
                </tr>
                <tr>
                  <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 11.81%">
                    <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">6</div>
                  </td>
                  <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 54.59%">
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SHARED VOTING POWER</div>
                    <div style="LINE-HEIGHT: 1.25">&#160;</div>
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">
                            <div style="line-height: 1.25;">
                              <div style="line-height: 1.25; margin-right: 30pt;">
                                <div style="line-height: 1.25;">
                                  <div style="line-height: 1.25;">
                                    <div style="line-height: 1.25;">
                                      <div style="line-height: 1.25;">
                                        <div style="line-height: 1.25;">&#160;250,000 (*)</div>
                                      </div>
                                    </div>
                                  </div>
                                </div>
                              </div>
                            </div>
                          </div>
                        </div>
                      </div>
                    </div>
                  </td>
                </tr>
                <tr>
                  <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 11.81%">
                    <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">7</div>
                  </td>
                  <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 54.59%">
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SOLE DISPOSITIVE POWER</div>
                    <div style="LINE-HEIGHT: 1.25">&#160;</div>
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">---</div>
                  </td>
                </tr>
                <tr>
                  <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 11.81%">
                    <div style="font-weight: bold; text-align: center; line-height: 1.25; margin-right: 30pt;">8</div>
                  </td>
                  <td colspan="3" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 54.59%">
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">SHARED DISPOSITIVE POWER</div>
                    <div style="LINE-HEIGHT: 1.25">&#160;</div>
                    <div style="LINE-HEIGHT: 1.25">
                      <div style="text-align: left; line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">
                            <div style="line-height: 1.25;">
                              <div style="line-height: 1.25; margin-right: 30pt;">
                                <div style="line-height: 1.25;">
                                  <div style="line-height: 1.25;">
                                    <div style="line-height: 1.25;">
                                      <div style="line-height: 1.25;">
                                        <div style="line-height: 1.25;">&#160;250,000 (*)</div>
                                      </div>
                                    </div>
                                  </div>
                                </div>
                              </div>
                            </div>
                          </div>
                        </div>
                      </div>
                    </div>
                  </td>
                </tr>
                <tr>
                  <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                    <div style="font-weight: bold; text-align: center; line-height: 1.25;">9</div>
                  </td>
                  <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON</div>
                    <div style="LINE-HEIGHT: 1.25">&#160;</div>
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">
                            <div style="line-height: 1.25;">
                              <div style="line-height: 1.25; margin-right: 30pt;">
                                <div style="line-height: 1.25;">
                                  <div style="line-height: 1.25;">
                                    <div style="line-height: 1.25;">
                                      <div style="line-height: 1.25;">
                                        <div style="line-height: 1.25;">&#160;250,000 (*)</div>
                                      </div>
                                    </div>
                                  </div>
                                </div>
                              </div>
                            </div>
                          </div>
                        </div>
                      </div>
                    </div>
                  </td>
                </tr>
                <tr>
                  <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                    <div style="font-weight: bold; text-align: center; line-height: 1.25;">10</div>
                  </td>
                  <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (See instructions)</div>
                    <div style="TEXT-ALIGN: left; LINE-HEIGHT: 1.25; MARGIN-RIGHT: 30pt">&#160;</div>
                    <div style="LINE-HEIGHT: 1.25">&#9744;</div>
                  </td>
                </tr>
                <tr>
                  <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                    <div style="font-weight: bold; text-align: center; line-height: 1.25;">11</div>
                  </td>
                  <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9</div>
                    <div style="LINE-HEIGHT: 1.25">&#160;</div>
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">
                      <div style="line-height: 1.25;">
                        <div style="line-height: 1.25;">
                          <div style="line-height: 1.25;">
                            <div style="line-height: 1.25;">
                              <div style="line-height: 1.25;">1.51% (*) (**)</div>
                            </div>
                          </div>
                        </div>
                      </div>
                    </div>
                  </td>
                </tr>
                <tr>
                  <td style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 5.56%">
                    <div style="font-weight: bold; text-align: center; line-height: 1.25;">12</div>
                  </td>
                  <td colspan="5" style="BORDER-TOP: #000000 2px solid; BORDER-RIGHT: #000000 2px solid; VERTICAL-ALIGN: top; BORDER-BOTTOM: #000000 2px solid; BORDER-LEFT: #000000 2px solid; WIDTH: 94.44%">
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">TYPE OF REPORTING PERSON&#160;&#160; (See instructions)</div>
                    <div style="LINE-HEIGHT: 1.25">&#160;</div>
                    <div style="text-align: left; line-height: 1.25; margin-right: 30pt;">CO</div>
                  </td>
                </tr>

            </table>
            <div style="LINE-HEIGHT: 1.25"><br style="LINE-HEIGHT: 1.25">
            </div>
          </div>
        </div>
      </div>
    </div>
    <div style="line-height: 1.25;">(*) Reflects updated holdings as of the date of this filing. The beneficial ownership of the securities reported herein is described in Item 4(a).</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">(**) Based on (i) 16,286,645 shares of Common Stock outstanding as of November 2, 2020 (as provided in the Issuer's Form 10-Q filed with the Securities and Exchange Commission (the &#8220;SEC&#8221;) on
        November 5, 2020) and (ii) certain warrants held by the Reporting Persons that are currently exercisable into shares of Common Stock.</div>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">5</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;">
          <div>
            <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable">

                <tr>
                  <td style="width: 45.8pt;"><font style="font-weight: bold;">Item 1.</font> </td>
                  <td style="width: 32.2pt; vertical-align: top; align: right;">(a)</td>
                  <td style="width: auto; vertical-align: top;">
                    <div>
                      <div><u>Name of Issuer</u>:</div>
                    </div>
                  </td>
                </tr>

            </table>
          </div>
        </div>
        <div style="line-height: 1.25;"><br style="line-height: 1.25;">
        </div>
      </div>
    </div>
    <div style="line-height: 1.25;">
      <div> </div>
    </div>
    <div style="text-indent: 28.35pt; margin-left: 49.65pt; line-height: 1.25;">X4 Pharmaceuticals, Inc.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;">
          <div style="line-height: 1.25;">
            <div>
              <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable">

                  <tr>
                    <td style="width: 45.8pt;"> <br>
                    </td>
                    <td style="width: 32.2pt; vertical-align: top; align: right;">(b)</td>
                    <td style="width: auto; vertical-align: top;">
                      <div>
                        <div>
                          <div><u>Address of Issuer's Principal Executive Offices</u>:</div>
                        </div>
                      </div>
                    </td>
                  </tr>

              </table>
            </div>
          </div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
        </div>
      </div>
    </div>
    <div style="line-height: 1.25;">
      <div> </div>
    </div>
    <div style="text-indent: 28.35pt; margin-left: 49.65pt; line-height: 1.25;">
      <div style="line-height: 1.25;"><font style="font-family: 'Times New Roman',Times,serif;">61 North Beacon Street,</font> <font style="font-family: 'Times New Roman',Times,serif;">4th Floor, Boston, Massachusetts 02134</font></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">
        <div>
          <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable">

              <tr>
                <td style="width: 45.8pt;"><font style="font-weight: bold;">Item 2.</font> </td>
                <td style="width: 32.2pt; vertical-align: top; align: right;">(a)</td>
                <td style="width: auto; vertical-align: top;">
                  <div><u>Address of Principal Business Office</u>:</div>
                </td>
              </tr>

          </table>
        </div>
      </div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="text-indent: 0pt; margin-left: 78pt; line-height: 1.25;">Moshe Arkin</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: -78pt; margin-left: 156pt; line-height: 1.25;">Sphera Funds Management Ltd.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: -78pt; margin-left: 156pt; line-height: 1.25;">Sphera Global Healthcare GP Ltd.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: -78pt; margin-left: 156pt; line-height: 1.25;">Sphera Global Healthcare Management LP</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z39475d86c65041f6aefc58db8283a331">

            <tr>
              <td style="width: 45.8pt;"><br>
              </td>
              <td style="width: 32.2pt; vertical-align: top; align: right;">(b)</td>
              <td style="width: auto; vertical-align: top;">
                <div><u>Address of Principal Business Office</u>:</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Moshe Arkin &#8211; <font style="background-color: #FFFFFF;">6 Hachoshlim St., Herzelia, Israel</font></div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Sphera Funds Management Ltd. &#8211; 21 Ha'arba'ah Street, Tel Aviv 64739, Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Sphera Global Healthcare GP Ltd. &#8211; 21 Ha'arba'ah Street, Tel Aviv 64739, Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Sphera Global Healthcare Management LP &#8211; 21 Ha'arba'ah Street, Tel Aviv 64739, Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zac693451898e4bf5a16ca1d1c995b549">

            <tr>
              <td style="width: 45.8pt;"><br>
              </td>
              <td style="width: 32.2pt; vertical-align: top; align: right;">(c)</td>
              <td style="width: auto; vertical-align: top;">
                <div><u>Citizenship</u>:</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Moshe Arkin &#8211; Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Sphera Funds Management Ltd. &#8211; Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Sphera Global Healthcare GP Ltd. &#8211; Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Sphera Global Healthcare Management LP &#8211; Israel</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z428b98dcd3974586bbeb0774ca7b83d6">

            <tr>
              <td style="width: 45.8pt;"><br>
              </td>
              <td style="width: 32.2pt; vertical-align: top; align: right;">(d)</td>
              <td style="width: auto; vertical-align: top;">
                <div><u>Title of Class of Securities</u>:</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Common Stock, $0.001 par value</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zcaeb1c475db84a2783f0b7482019b110">

            <tr>
              <td style="width: 45.75pt;"><br>
              </td>
              <td style="width: 32.25pt; vertical-align: top; align: right;">(e)</td>
              <td style="width: auto; vertical-align: top;">
                <div><u>CUSIP Number</u>:</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">98420X103</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zaa7916d61a294b738fe5e6893d84d84f">

            <tr>
              <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 3</font>.</td>
              <td style="width: auto; vertical-align: top;">
                <div>Not applicable.</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <br>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">6</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;">
      <div>
        <div>
          <div style="line-height: 1.25;"><br style="line-height: 1.25;">
          </div>
          <div style="line-height: 1.25;">
            <div>
              <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable">

                  <tr>
                    <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 4</font>.</td>
                    <td style="width: auto; vertical-align: top;">
                      <div><u>Ownership</u>:</div>
                    </td>
                  </tr>

              </table>
              <div>&#160;</div>
            </div>
          </div>
        </div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z034d90b5ed734200b05ebd153f6fda6c">

            <tr>
              <td style="width: 42.55pt;"><br>
              </td>
              <td style="width: 35.45pt; vertical-align: top; align: right;">(a)</td>
              <td style="width: auto; vertical-align: top;">
                <div><u>Amount beneficially owned</u>:</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 0pt; margin-left: 78pt; line-height: 1.25;">See row 9 of cover page of each reporting person.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 0pt; margin-left: 78pt; line-height: 1.25;">The securities reported herein are beneficially owned as follows:</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <table cellspacing="0" cellpadding="0" id="z0109effbb9a74f068cf71fb42faa22f4" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 77.95pt;"><br>
            </td>
            <td style="width: 21.25pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>140,000 Warrants 15 currently exercisable into shares of Common Stock,
                representing a total of 0.85% of the total shares of Common Stock outstanding (including the warrants held by the Reporting Persons), are held directly by
                Sphera Global Healthcare Master Fund, which has delegated its investment management authority to Sphera Global Healthcare Management Ltd. (the "Management Company").</div>
            </td>
          </tr>

      </table>
      <div style="line-height: 1.25">&#160;</div>
      <table cellspacing="0" cellpadding="0" id="z0f0287bf7fd54941ac74c6b03b5b4901" class="DSPFListTable" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;">

          <tr>
            <td style="width: 78pt;"><br>
            </td>
            <td style="width: 21.25pt; vertical-align: top; align: right;">&#8226;</td>
            <td style="width: auto; vertical-align: top; text-align: justify;">
              <div>75,000 Warrants 13.2 and 35,000 Warrants 15, together currently exercisable into shares
                  of Common Stock, representing a total of 0.66% of the total shares of Common Stock outstanding (including the warrants held by the Reporting
                Persons), are held directly by Sphera Biotech Master Fund, L.P., which has delegated its investment management authority to the Management Company.</div>
            </td>
          </tr>

      </table>
    </div>
    <br>
    <div style="text-align: justify; margin-left: 78pt; line-height: 1.25;">
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">The Management Company is managed,
          controlled, and operated by its general partner, Sphera Global Healthcare GP Ltd., which is controlled by Sphera Funds Management Ltd.</div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; margin-left: 78pt; line-height: 1.25;">This Statement shall not be construed as an admission by any of the Reporting Persons that it is the beneficial owner of any of the securities covered by this Statement, and each
      Reporting Person disclaims beneficial ownership of any such securities.&#160; In addition, the Reporting Persons and other entities named in this Schedule 13G may be deemed to constitute a "group" for purposes of Section 13(d) of the Securities Exchange
      Act of 1934.&#160; Neither the filing of this Schedule 13G nor any of its contents shall be deemed to constitute an admission that a group exists for purposes of Section 13(d) of the Securities Exchange Act of 1934 or for any other purpose, and each of
      the Reporting Persons and other entities named in this Schedule 13G disclaims the existence of any such group.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="za2101e77a8f44a3d8d5623137db1897f">

            <tr>
              <td style="width: 42.55pt;"><br>
              </td>
              <td style="width: 35.25pt; vertical-align: top; align: right;">(b)</td>
              <td style="width: auto; vertical-align: top;">
                <div><u>Percent of class</u>:</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 0pt; margin-left: 78pt; line-height: 1.25;">See row 11 of cover page of each reporting person</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z29a1ce1377624105bba56217ce54849f">

            <tr>
              <td style="width: 42.55pt;"><br>
              </td>
              <td style="width: 35.45pt; vertical-align: top; align: right;">(c)</td>
              <td style="width: auto; vertical-align: top;">
                <div><u>Number of shares as to which such person has</u>:</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z0ce05fa2292f4296998a0346b8b0ac16">

            <tr>
              <td style="width: 77.8pt;"><br>
              </td>
              <td style="width: 28.55pt; vertical-align: top; align: right;">(i)</td>
              <td style="width: auto; vertical-align: top;">
                <div>Sole power to vote or to direct the vote:</div>
                <div> <br>
                </div>
                <div>
                  <div style="line-height: 1.25;">See row 5 of cover page of each reporting person</div>
                </div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z2b3b897628114a01a277143401faceaf">

            <tr>
              <td style="width: 77.8pt;"><br>
              </td>
              <td style="width: 28.55pt; vertical-align: top; align: right;">(ii)</td>
              <td style="width: auto; vertical-align: top;">
                <div>Shared power to vote or to direct the vote:</div>
                <div> <br>
                </div>
                <div>
                  <div style="line-height: 1.25;">See row 6 of cover page of each reporting person and note in Item 4(a) above</div>
                </div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zc53c5b04158f4355afa65c2f4a081ec3">

            <tr>
              <td style="width: 77.8pt;"><br>
              </td>
              <td style="width: 28.55pt; vertical-align: top; align: right;">(iii)</td>
              <td style="width: auto; vertical-align: top;">
                <div>Sole power to dispose or to direct the disposition of:</div>
                <div> <br>
                </div>
                <div>
                  <div style="line-height: 1.25;">See row 7 of cover page of each reporting person</div>
                </div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">7</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z0e9133d47725431599ff552371f456e1">

            <tr>
              <td style="width: 77.8pt;"><br>
              </td>
              <td style="width: 28.55pt; vertical-align: top; align: right;">(iv)</td>
              <td style="width: auto; vertical-align: top;">
                <div>Shared power to dispose or to direct the disposition of:</div>
                <div> <br>
                </div>
                <div>
                  <div style="line-height: 1.25;">See row 8 of cover page of each reporting person and note in Item 4(a) above</div>
                </div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb09026cccaf14029b3c93cd0b62fecf5">

            <tr>
              <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 5</font>.</td>
              <td style="width: auto; vertical-align: top;">
                <div><u>Ownership of Five Percent or Less of a Class</u>:</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="text-indent: -78pt; margin-left: 78pt; line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">
      <div style="line-height: 1.25; font-family: 'Times New Roman',Times,serif;">If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the
        beneficial owner of more than 5 percent of the class of securities, check the following &#9746;.</div>
      <div style="line-height: 1.25;"><br style="line-height: 1.25;">
      </div>
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z6dc03d3081c440c19f9453c79a93583c">

            <tr>
              <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 6</font>.</td>
              <td style="width: auto; vertical-align: top;">
                <div><u>Ownership of More than Five Percent on Behalf of Another</u>:</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="za31a45bbc58b43eba09fac299f710495">

            <tr>
              <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 7</font>.</td>
              <td style="width: auto; vertical-align: top;">
                <div><u>Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person</u>:</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z3b62dcbf1cbc4666ba3a061918007686">

            <tr>
              <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 8</font>.</td>
              <td style="width: auto; vertical-align: top;">
                <div><u>Identification and Classification of Members of the Group</u>:</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="z01556e8b15974233b3845082aed9f762">

            <tr>
              <td style="width: 78pt; vertical-align: top; align: right;"><font style="font-weight: bold;">Item 9</font>.</td>
              <td style="width: auto; vertical-align: top;">
                <div><u>Notice of Dissolution of Group</u>:</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="margin-left: 78pt; line-height: 1.25;">Not applicable.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">8</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div>
        <table cellspacing="0" cellpadding="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" class="DSPFListTable" id="zb362d58d508049e98ad3a2dc8c8b6621">

            <tr>
              <td style="width: 78pt; vertical-align: top; align: right; font-weight: bold;">Item 10.</td>
              <td style="width: auto; vertical-align: top;">
                <div><u>Certification</u>:</div>
              </td>
            </tr>

        </table>
      </div>
    </div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; text-indent: 35.45pt; line-height: 1.25;">By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the
      effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.</div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">9</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="text-align: center; line-height: 1.25;">&#160;<font style="font-weight: bold;">SIGNATURE</font></div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-indent: 35.45pt; line-height: 1.25;">After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.</div>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="line-height: 1.25;">
      <div style="line-height: 1.25;">
        <div style="line-height: 1.25;">February 10, 2021</div>
      </div>
    </div>
    <div style="line-height: 1.25">&#160;</div>
    <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; width: 100%; text-align: left; color: #000000;" id="z5de77bbda7a7489688f464635b606ee7">

        <tr>
          <td style="width: 50%; vertical-align: top;">&#160;</td>
          <td style="width: 50%; vertical-align: top;">
            <div style="line-height: 1.25; font-weight: bold;">Moshe Arkin</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="line-height: 1.25; font-style: italic;"><u>/s/ Moshe Arkin</u></div>
            <div style="line-height: 1.25;">By: Moshe Arkin</div>
            <div style="line-height: 1.25;"><font style="line-height: 1.25;">&#160;</font></div>
            <div style="line-height: 1.25;"><font style="font-weight: bold;">Sphera Funds Management Ltd.</font><br>
              <br>
              <u><font style="font-style: italic;">/s/ Ori Goldfarb</font></u></div>
            <div style="line-height: 1.25;">By: Ori Goldfarb<br>
              Title: Chief Executive Officer</div>
            <div style="line-height: 1.25;"> <br>
            </div>
            <div style="line-height: 1.25;">
              <div style="line-height: 1.25;"><font style="font-weight: bold;">Sphera Global Healthcare GP Ltd.</font><br>
                <br>
                <font style="font-style: italic;"><u>/s/ Ori Goldfarb</u></font><br>
                By: Ori Goldfarb<br>
                Title: Chief Executive Officer</div>
              <div style="line-height: 1.25;"><br style="line-height: 1.25;">
              </div>
              <div style="line-height: 1.25;"><font style="font-weight: bold;">Sphera Global Healthcare Management LP</font><br>
                <br>
                <font style="font-style: italic;"><u>/s/ Doron Breen</u></font><br>
                By: Doron Breen<br>
                Title: Managing Partner</div>
            </div>
          </td>
        </tr>

    </table>
    <div style="margin-left: 205.55pt; line-height: 1.25;"><br>
    </div>
    <div style="clear: both; margin-top: 10pt; margin-bottom: 10pt;" id="DSPFPageBreakArea">
      <div style="text-align: center;" id="DSPFPageNumberArea"><font style="color: #000000; font-weight: normal; font-style: normal;" id="DSPFPageNumber">10</font></div>
      <div style="page-break-after: always;" id="DSPFPageBreak">
        <hr noshade="noshade" style="border-width: 0px; clear: both; margin: 4px 0px; width: 100%; height: 2px; color: #000000; background-color: #000000;"></div>
    </div>
    <div style="text-align: justify; line-height: 1.25;">
      <table cellspacing="0" cellpadding="0" border="0" style="font-family: 'Times New Roman', Times, serif; font-size: 10pt; color: #000000; width: 100%;" id="z2d765a2f411e486396e8699f05d1df59">

          <tr>
            <td style="width: 12%;">
              <div>
                <div style="text-align: justify; line-height: 1.25;"><font style="font-weight: bold;">EXHIBIT NO.</font>&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;</div>
              </div>
            </td>
            <td style="width: 88%;">
              <div><font style="font-weight: bold;">DESCRIPTION</font></div>
            </td>
          </tr>
          <tr>
            <td style="width: 12%;" rowspan="1">&#160;</td>
            <td style="width: 88%;" rowspan="1">&#160;</td>
          </tr>
          <tr>
            <td style="width: 12%;">
              <div>Exhibit 1</div>
            </td>
            <td style="width: 88%;">
              <div>
                <div>
                  <div>Joint Filing Agreement by and among the Reporting Persons, dated as of December 23, 2019 (incorporated herein by reference to Exhibit 1 to the Schedule 13G filed on December 23, 2019).</div>
                </div>
              </div>
            </td>
          </tr>

      </table>
      <font style="font-weight: bold;"> </font></div>
    <br>
    <div style="line-height: 1.25;"><br style="line-height: 1.25;">
    </div>
    <div style="text-align: justify; line-height: 1.25;">
      <div> </div>
    </div>
    <div style="line-height: 1.25; text-align: center;"><font style="font-family: 'Times New Roman',Times,serif; color: rgb(0, 0, 0); font-weight: normal; font-style: normal;" id="DSPFPageNumber">11</font></div>
  </div>
  <div style="text-align: center;" id="DSPFPageNumberArea">
    <hr align="center" style="border: none; border-bottom: 4px solid black; border-top: 1px solid black; height: 10px; color: #ffffff; background-color: #ffffff; margin-left: auto; margin-right: auto;"></div>
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</html>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
