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v3.22.1

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2022 | Mar. 31, 2021
Cash flows from operating activities: |  |
Net loss | $ (21,965) | $ (18,676)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Stock-based compensation expense | 1,459 | 1,258
Depreciation and amortization expense | 133 | 106
Non-cash lease expense | 366 | 314
Accretion of debt discount | 198 | 178
Other | (120) | 99
Changes in operating assets and liabilities: |  |
Prepaid expenses, other current assets and research and development incentive receivable | 1,633 | (711)
Accounts payable | (713) | (23)
Accrued expenses | (984) | (786)
Lease liabilities | (236) | (160)
Operating lease right-of-use asset, net of non-cash portion | 0 | 43
Net cash used in operating activities | (20,229) | (18,444)
Cash flows from investing activities: |  |
Acquisition of property, equipment and intangible assets | (22) | (496)
Net cash used in investing activities | (22) | (496)
Cash flows from financing activities: |  |
Proceeds from exercise of stock options and pre-funded warrants and issuance of shares of common stock under employee stock purchase plan | 0 | 41
Employee taxes paid related to net share settlement of vested restricted stock units | (12) | 0
Proceeds from borrowings under loan and security agreements, net of issuance costs | (114) | 0
Repayments of Secured Debt | (795) | 0
Proceeds from sale of shares of common stock, redeemable common stock and pre-funded warrants, net of issuance costs | 5,877 | 55,000
Net cash provided by financing activities | 4,956 | 55,041
Effect of exchange rate changes on cash, cash equivalents and restricted cash | (69) | (143)
Net (decrease) increase in cash, cash equivalents and restricted cash | (15,364) | 35,958
Cash, cash equivalents and restricted cash at beginning of period | 83,108 | 80,702
Cash, cash equivalents and restricted cash at end of period | 67,744 | 116,660
Supplemental disclosure of non-cash investing and financing activities: |  |
Acquisition of property, equipment and right-of-use assets included in accounts payable and accrued expenses | 0 | 17
Acquisition of right-of-use asset financed by lease liabilities | 0 | 1,343
Issuance costs not yet paid related to sale of shares of common stock, redeemable common stock and pre-funded warrants | $ 0 | $ 3,485

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- Definition Amount of cash outflow to satisfy grantee's tax withholding obligation for award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3291-108585 + Details
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- Definition The cash outflow for purchases of and capital improvements on property, plant and equipment (capital expenditures), software, and other intangible assets. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3213-108585 Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 50 -Section 30 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=123362884&loc=d3e9212-128498 Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 50 -Section 30 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=123362884&loc=d3e9215-128498 Reference 4: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 50 -Section 25 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=123385561&loc=d3e9135-128495 + Details
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- Definition The cash outflow to repay long-term debt that is wholly or partially secured by collateral. Excludes repayments of tax exempt secured debt. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3291-108585 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=123570139&loc=d3e3602-108585 + Details
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