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License, Collaboration, and Funding Agreements - Additional Information (Detail) | 3 Months Ended
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Mar. 31, 2024 USD ($) | Mar. 31, 2023 USD ($)
Collaboration License And Funding Arrangements [Line Items] |  |
Other income, net | $ 105,000 | $ 123,000
Research and Development Incentive |  |
Collaboration License And Funding Arrangements [Line Items] |  |
Grant receivable | 700,000 |
Other income, net | 200,000 | $ 100,000
Genzyme Agreement |  |
Collaboration License And Funding Arrangements [Line Items] |  |
Milestone Payments | 20,000,000 |
Collaborative Arrangement, Rights and Obligations, Maximum Aggregate Milestone Payments, Per Product | $ 7,000,000 |
Genzyme Agreement | 6% Net Sales |  |
Collaboration License And Funding Arrangements [Line Items] |  |
Revenue, Performance Obligation, Percentage of Net Sale | 0.06 |
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer | $ 150,000,000 |
Genzyme Agreement | 10% Net Sales |  |
Collaboration License And Funding Arrangements [Line Items] |  |
Revenue, Performance Obligation, Percentage of Net Sale | 0.10 |
Genzyme Agreement | 10% Net Sales | Minimum |  |
Collaboration License And Funding Arrangements [Line Items] |  |
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer | $ 150,000,000 |
Genzyme Agreement | 10% Net Sales | Maximum |  |
Collaboration License And Funding Arrangements [Line Items] |  |
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer | $ 300,000,000 |
Genzyme Agreement | 12% Net Sales |  |
Collaboration License And Funding Arrangements [Line Items] |  |
Revenue, Performance Obligation, Percentage of Net Sale | 0.12 |
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer | $ 300,000,000 |

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- Definition Collaborative Arrangement, Rights and Obligations, Maximum Aggregate Milestone Payments, Per Product + References No definition available. + Details
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