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CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2024
Mar. 31, 2023
Cash flows from operating activities:    
Net loss $ (51,766) $ (24,020)
Adjustments to reconcile net loss to net cash used in operating activities:    
Stock-based compensation expense 1,739 1,645
Depreciation and amortization expense 62 127
Non-cash lease expense 386 385
Accretion of debt discount 254 225
Change in fair value of warrant liability 13,755 (5,439)
Other (117) (51)
Changes in operating assets and liabilities:    
Prepaid expenses, other current assets and research and development incentive receivable 1,062 2,084
Accounts payable 4 (1,714)
Accrued expenses and other long-term liabilities 1,264 496
Lease liabilities (240) (250)
Net cash used in operating activities (33,597) (26,512)
Cash flows from investing activities:    
Payments to Acquire Marketable Securities (10,263) 0
Sales and maturities of marketable securities 5,000 0
Acquisition of property and equipment (59) (9)
Net cash used in investing activities (5,322) (9)
Cash flows from financing activities:    
Fees paid to amendment loan and security agreement and issuance costs related to the sale of warrants 0 (381)
Repayments of Secured Debt 0 (1,300)
Proceeds from sale of common stock, warrants and pre-funded warrants, net of issuance costs 0 (443)
Net cash used in financing activities 0 (2,124)
Effect of exchange rate changes on cash, cash equivalents and restricted cash (59) 50
Net decrease in cash, cash equivalents and restricted cash (38,978) (28,595)
Cash, cash equivalents and restricted cash at beginning of period 100,248 123,028
Cash, cash equivalents and restricted cash at end of period $ 61,270 $ 94,433