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License, and Funding Agreements - Additional Information (Detail) | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 30, 2024 USD ($) | Jun. 30, 2023 USD ($) | Jun. 30, 2024 USD ($) | Jun. 30, 2023 USD ($)
Collaboration License And Funding Arrangements [Line Items] |  |  |  |
Other income, net | $ 144,000 | $ 202,000 | $ 249,000 | $ 325,000
Collaborative Arrangement, Rights and Obligations, Maximum Aggregate Milestone Payments, Remaining |  |  | 3,000,000.0 |
Collaborative Arrangement, Rights and Obligations, Maximum Aggregate Milestone Payments |  |  | 5,000,000.0 |
Research and Development Incentive |  |  |  |
Collaboration License And Funding Arrangements [Line Items] |  |  |  |
Grant receivable | 900,000 |  | 900,000 |
Other income, net |  |  | 300,000 | $ 300,000
Genzyme Agreement |  |  |  |
Collaboration License And Funding Arrangements [Line Items] |  |  |  |
Milestone Payments |  |  | 13,000,000 |
Collaborative Arrangement, Rights and Obligations, Maximum Aggregate Milestone Payments, Per Product | $ 7,000,000 |  | $ 7,000,000 |
Genzyme Agreement | 6% Net Sales |  |  |  |
Collaboration License And Funding Arrangements [Line Items] |  |  |  |
Revenue, Performance Obligation, Percentage of Net Sale | 0.06 |  | 0.06 |
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer |  |  | $ 150,000,000 |
Genzyme Agreement | 10% Net Sales |  |  |  |
Collaboration License And Funding Arrangements [Line Items] |  |  |  |
Revenue, Performance Obligation, Percentage of Net Sale | 0.10 |  | 0.10 |
Genzyme Agreement | 10% Net Sales | Minimum |  |  |  |
Collaboration License And Funding Arrangements [Line Items] |  |  |  |
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer |  |  | $ 150,000,000 |
Genzyme Agreement | 10% Net Sales | Maximum |  |  |  |
Collaboration License And Funding Arrangements [Line Items] |  |  |  |
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer |  |  | $ 300,000,000 |
Genzyme Agreement | 12% Net Sales |  |  |  |
Collaboration License And Funding Arrangements [Line Items] |  |  |  |
Revenue, Performance Obligation, Percentage of Net Sale | 0.12 |  | 0.12 |
Revenue from Collaborative Arrangement, Excluding Revenue from Contract with Customer |  |  | $ 300,000,000 |

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