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Stock-Based Compensation (Details) (USD $) | 12 Months Ended |
--- | --- | ---
Dec. 31, 2014 | Dec. 31, 2013 | Dec. 31, 2012
Stock-Based Compensation |  |  |
Options outstanding (in shares) | 3,648,247 us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber | 389,436 us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber | 79,436 us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber
Stock option compensation expense |  |  |
Stock based compensation expense | $ 1,606,947 us-gaap_AllocatedShareBasedCompensationExpense | $ 2,225,989 us-gaap_AllocatedShareBasedCompensationExpense |
Research and development |  |  |
Stock option compensation expense |  |  |
Stock based compensation expense | 526,331 us-gaap_AllocatedShareBasedCompensationExpense / us-gaap_IncomeStatementLocationAxis = us-gaap_ResearchAndDevelopmentExpenseMember |  |
General and administrative |  |  |
Stock option compensation expense |  |  |
Stock based compensation expense | $ 1,080,616 us-gaap_AllocatedShareBasedCompensationExpense / us-gaap_IncomeStatementLocationAxis = us-gaap_GeneralAndAdministrativeExpenseMember | $ 2,225,989 us-gaap_AllocatedShareBasedCompensationExpense / us-gaap_IncomeStatementLocationAxis = us-gaap_GeneralAndAdministrativeExpenseMember |

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- Definition Number of options outstanding, including both vested and non-vested options. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1)(i)-(ii) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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