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Note 10 - Stock-Based Compensation (Tables)
9 Months Ended
Sep. 30, 2015
Notes Tables  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
 
 
Three Months Ended
September 30
,
 
 
Nine
Months Ended
September 30
,
 
 
 
2015
 
 
2014
 
 
2015
 
 
2014
 
Research and development
  $ 106,692     $ 342,997     $ 490,862     $ 375,821  
General and administrative
    374,545       440,935       1,122,992       699,310  
                                 
Total stock-based compensation expense
  $ 481,237     $ 783,932     $ 1,613,854     $ 1,075,131