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Note 3 - Summary of Significant Accounting Policies (Tables) | 12 Months Ended
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Dec. 31, 2015
Notes Tables |
Schedule of Property, Plant, and Equipment Usefu lLife [Table Text Block] |
Equipment ( years) | 3 | – | 5
Furniture and fixtures ( years) |  | 5 |
Leasehold improvements | Lesser of lease term or life of improvements

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- Definition Tabular disclosure of the useful life of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References No definition available. + Details
Name: | dffn_ScheduleOfPropertyPlantAndEquipmentUsefuLlifeTableTextBlock
Namespace Prefix: | dffn_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

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- References No definition available. + Details
Name: | us-gaap_TableTextBlock
Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration