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Note 11 - Commitments and Contingencies (Details Textual) |  |  | 3 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Sep. 04, 2014 USD ($) ft² | Dec. 15, 2009 USD ($) $ / shares shares | Dec. 31, 2015 shares | Dec. 31, 2015 USD ($) | Sep. 21, 2015 $ / shares
RES-440 and RES-529 [Member] |  |  |  |  |
Long-term Purchase Commitment, Amount |  |  |  | $ 0 |
Buffalo Grove [Member] | Building [Member] | Long Term Operating Lease Agreement [Member] |  |  |  |  |
Area of Real Estate Property | ft² | 2,900 |  |  |  |
Lessee Leasing Arrangements Operating Leases Number of Extension Options | 1 |  |  |  |
Lessee Leasing Arrangements, Operating Leases, Renewal Term | 3 years |  |  |  |
Operating Leases, Number of Months from Lease Inception that Monthly Rent is Not Required to Be Paid | 5 |  |  |  |
Operating Leases Monthly Rent Expense | $ 6,000 |  |  |  |
Operating Leases Annual Rent Expense | 72,000 |  |  |  |
Operating Leases Annual Increase in Rent Expense for First Year | 6,100 |  |  |  |
Operating Leases Annual Increase in Rent Expense For Second Year and Thereafter | $ 6,200 |  |  |  |
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member] | Scenario, Actual [Member] |  |  |  |  |
Debt Instrument, Convertible, Conversion Price | $ / shares |  | $ 3.50 |  |  |
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member] | Plaintiff's Assertion of Entitled Conversion Price [Member] |  |  |  |  |
Debt Instrument, Convertible, Conversion Price | $ / shares |  |  |  |  | $ 1
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member] | If Conversion Price $1.00 per Unit Rather Than $3.50 per Unit [Member] |  |  |  |  |
Debt Conversion, Converted Instrument, Shares Issued | shares |  | 1,071,432.5 |  |  |
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member] |  |  |  |  |
Debt Conversion, Original Debt, Amount |  | $ 1,500,000 |  |  |
Loss Contingency, Damages Sought, Shares | shares |  |  | 1,071,432.5 |  |

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