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Note 10 - Stock-based Compensation - Stock Option Activity (Details) - $ / shares
 12 Months Ended
Dec. 31, 2015
Dec. 31, 2014
Dec. 31, 2013
Options outstanding (in shares) 3,648,247 389,436  
Options outstanding, weighted-average per share exercise price (in dollars per share) $ 5.44 $ 11.77  
Options outstanding, weighted-average remaining contractual life 7 years 146 days 8 years 292 days 3 years 328 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number 1,861,952 1,072,111 367,110
Shares of common stock, vested, weighted-average per share exercise price (in dollars per share) $ 4.22 $ 9.49 $ 11.10
Shares of common stock, vested, weighted-average remaining contractual life 6 years 255 days 7 years 73 days 3 years 328 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross 6,650 3,287,181  
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price $ 1.90 $ 3.71  
Options exercised (in shares)  
Options exercised, weighted-average per share exercise price (in dollars per share)  
Options forfeited or expired (in shares) (643,399) (28,370)  
Options forfeited or expired, weighted-average per share exercise price (in dollars per share) $ 6.28 $ 33.99  
Options outstanding (in shares) 3,011,498 3,648,247 389,436
Options outstanding, weighted-average per share exercise price (in dollars per share) $ 4.01 $ 5.44 $ 11.77