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Note 11 - Commitments and Contingencies (Details Textual)
 3 Months Ended 12 Months Ended
Sep. 04, 2014
USD ($)
ft²
Dec. 15, 2009
USD ($)
$ / shares
shares
Dec. 31, 2015
shares
Dec. 31, 2015
USD ($)
Sep. 21, 2015
$ / shares
RES-440 and RES-529 [Member]          
Long-term Purchase Commitment, Amount       $ 0  
Buffalo Grove [Member] | Building [Member] | Long Term Operating Lease Agreement [Member]          
Area of Real Estate Property | ft² 2,900        
Lessee Leasing Arrangements Operating Leases Number of Extension Options 1        
Lessee Leasing Arrangements, Operating Leases, Renewal Term 3 years        
Operating Leases, Number of Months from Lease Inception that Monthly Rent is Not Required to Be Paid 5        
Operating Leases Monthly Rent Expense $ 6,000        
Operating Leases Annual Rent Expense 72,000        
Operating Leases Annual Increase in Rent Expense for First Year 6,100        
Operating Leases Annual Increase in Rent Expense For Second Year and Thereafter $ 6,200        
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member] | Scenario, Actual [Member]          
Debt Instrument, Convertible, Conversion Price | $ / shares   $ 3.50      
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member] | Plaintiff's Assertion of Entitled Conversion Price [Member]          
Debt Instrument, Convertible, Conversion Price | $ / shares         $ 1
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member] | If Conversion Price $1.00 per Unit Rather Than $3.50 per Unit [Member]          
Debt Conversion, Converted Instrument, Shares Issued | shares   1,071,432.5      
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member]          
Debt Conversion, Original Debt, Amount   $ 1,500,000      
Loss Contingency, Damages Sought, Shares | shares     1,071,432.5