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Note 15 - Investment in Or-Genix Therapeutics, Inc. (Details Textual) - USD ($)		12 Months Ended
	Apr. 30, 2015	Dec. 31, 2015	Dec. 31, 2014
Or Genix Therapeutics Inc [Member]
Cost Method Ownership Percentage	19.90%
Investment in Common Stock Shares	2,484,395
Payments to Acquire Investments	$ 250,000
Payments to Acquire Investments		$ 250,000

X

- Definition

The percentage of ownership of common stock or equity participation in the investee accounted for under the cost method.

+ References

No definition available.

+ Details

Name:	dffn_CostMethodOwnershipPercentage
Namespace Prefix:	dffn_
Data Type:	num:percentItemType
Balance Type:	na
Period Type:	instant

X

- Definition

Represents the shares of common stock acquired.

+ References

No definition available.

+ Details

Name:	dffn_InvestmentInCommonStockShares
Namespace Prefix:	dffn_
Data Type:	xbrli:sharesItemType
Balance Type:	na
Period Type:	duration

X

- Definition

The cash outflow associated with the purchase of all investments (debt, security, other) during the period.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Investing Activities
-URI http://asc.fasb.org/extlink&oid=6516133

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 13
-URI http://asc.fasb.org/extlink&oid=56944662&loc=d3e3213-108585

+ Details

Name:	us-gaap_PaymentsToAcquireInvestments
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	duration

X

- Details

Name:	us-gaap_CounterpartyNameAxis=dffn_OrGenixTherapeuticsIncMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type: