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Document And Entity Information - shares
 3 Months Ended
Mar. 31, 2016
May. 16, 2016
Entity Registrant Name Diffusion Pharmaceuticals Inc.  
Entity Central Index Key 0001053691  
Trading Symbol dffn  
Current Fiscal Year End Date --12-31  
Entity Filer Category Smaller Reporting Company  
Entity Current Reporting Status Yes  
Entity Voluntary Filers No  
Entity Well-known Seasoned Issuer No  
Entity Common Stock, Shares Outstanding (in shares)   102,429,200
Document Type 10-Q  
Document Period End Date Mar. 31, 2016  
Document Fiscal Year Focus 2016  
Document Fiscal Period Focus Q1  
Amendment Flag false