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Note 4 - Acquisition (Tables)
3 Months Ended
Mar. 31, 2016
Notes Tables  
Business Combination, Preliminary Purchase Price Consideration [Table Text Block]
Purchase consideration
       
Fair value of RestorGenex shares outstanding
  $ 19,546,000  
Estimated fair value of RestorGenex stock options assumed by Diffusion
    1,321,000  
Estimated fair value of RestorGenex warrants assumed by Diffusion
    384,000  
Contingent value rights – RES-440 product candidate
    10,000  
Total preliminary purchase price
  $ 21,261,000  
Schedule of Recognized Identified Assets Acquired and Liabilities Assumed [Table Text Block]
Cash and cash equivalents
  $ 8,500,602  
Prepaid expenses and other assets
    195,200  
Property and equipment
    57,531  
Intangible assets
    9,317,000  
Goodwill
    7,105,031  
Accrued liabilities
    (377,431 )
Deferred tax liability
    (3,536,933 )
Net assets acquired
  $ 21,261,000  
Schedule of Finite-Lived Intangible Assets [Table Text Block]
 
 
March 31, 2016
 
 
December 31, 2015
 
 
 
Gross
Carrying
Amount
 
 
Accumulated
Amortization
 
 
Intangible
Assets, net
 
 
Gross
Carrying
Amount
 
 
Accumulated Amortization
 
 
Intangible
Assets, net
 
RES-529
  $ 8,385,000     $ 0     $ 8,385,000     $ 0     $ 0     $ 0  
RES-440
  $ 932,000     $ 0     $ 932,000     $ 0     $ 0     $ 0  
Total in-process research and
development costs
(IPR&D)
  $ 9,317,000     $ 0     $ 9,317,000     $ 0     $ 0     $ 0  
Business Acquisition, Pro Forma Information [Table Text Block]
 
 
Three Months Ended
March 31, 2016
 
 
Three Months Ended
March 31, 2015
 
Net revenues
  $ 0     $ 0  
Net loss
 
(4,655,944
)  
(4,759,901
)
Basic and diluted loss per share
  $ (0.05 )   $ (0.12 )