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Note 8 - Stock-based Compensation (Tables)
3 Months Ended
Mar. 31, 2016
Notes Tables  
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]
   
Three months ended March 31,
 
   
2016
   
2015
 
Research and development
  $ 242,277     $ 39,956  
General and administrative
    151,194       55,900  
    $ 393,471     $ 95,856  
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]
   
Number of
Options
   
Weighted
average
exercise
 
price
per share
   
Weighted
average
remaining
contractual life
(in years)
 
Balance at January 1, 2016
    14,955,753     $ 0.39          
Assumed in connection with Merger
    3,011,498       4.02          
Cancelled
    (3,652 )     1.36          
Outstanding at March 31, 2016
    17,963,599     $ 1.00       7.8  
Exercisable at March 31, 2016
    12,306,562     $ 1.23       7.1  
Vested and expected to vest at March 31, 2016
    17,929,054     $ 1.00       7.8