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Note 4 - Acquisition (Tables)
6 Months Ended
Jun. 30, 2016
Notes Tables  
Business Combination, Preliminary Purchase Price Consideration [Table Text Block]
Purchase consideration
       
Fair value of RestorGenex shares outstanding
  $ 19,546,000  
Estimated fair value of RestorGenex stock options assumed by Diffusion
    1,321,000  
Estimated fair value of RestorGenex warrants assumed by Diffusion
    384,000  
CVRs – RES-440 product candidate
    10,000  
Total preliminary purchase price
  $ 21,261,000  
Schedule of Recognized Identified Assets Acquired and Liabilities Assumed [Table Text Block]
Cash and cash equivalents
  $ 8,500,602  
Prepaid expenses and other assets
    195,200  
Property and equipment
    57,531  
Intangible assets
    9,317,000  
Goodwill
    7,105,031  
Accrued liabilities
    (377,431 )
Deferred tax liability
    (3,536,933 )
Net assets acquired
  $ 21,261,000  
Schedule of Finite-Lived Intangible Assets [Table Text Block]
 
 
June 30, 2016
 
 
December 31, 2015
 
 
 
Gross
Carrying
Amount
 
 
Accumulated
Amortization
 
 
Intangible
Assets, net
 
 
Gross
Carrying
Amount
 
 
Accumulated Amortization
 
 
Intangible
Assets, net
 
RES 529
  $ 8,385,000     $ 0     $ 8,385,000     $ 0     $ 0     $ 0  
RES-440
    932,000       0       932,000       0       0       0  
Total in-process research and development costs (IPR&D)
  $ 9,317,000     $ 0     $ 9,317,000     $ 0     $ 0     $ 0  
Business Acquisition, Pro Forma Information [Table Text Block]
 
 
Three Months Ended
June 30,
 
 
Six Months Ended
June 30,
 
 
 
2016
 
 
2015
 
 
2016
 
 
2015
 
Net revenues
  $     $     $     $  
Net loss
  $ (3,806,194 )   $ (5,300,450 )   $ (8,464,138 )   $ (10,060,351 )
Basic and diluted loss per share
  $ (0.04 )   $ (0.13 )   $ (0.08 )   $ (0.24 )