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Note 9 - Commitments and Contingencies (Details Textual)			3 Months Ended		6 Months Ended
	Sep. 15, 2014 ft² shares	Dec. 15, 2009 USD ($) $ / shares shares	Jun. 30, 2016 USD ($) $ / shares shares	Jun. 30, 2015 USD ($)	Jun. 30, 2016 USD ($) $ / shares	Jun. 30, 2015 USD ($)	Dec. 31, 2012 $ / shares
Charlottesville, Virginia [Member] | Building [Member]
Operating Leases, Rent Expense, Net			$ 16,500	$ 33,000	$ 16,500	$ 33,000
Buffalo Grove [Member] | Building [Member] | Long Term Operating Lease Agreement [Member]
Area of Real Estate Property | ft²	2,900
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member] | Scenario, Actual [Member]
Debt Instrument, Convertible, Conversion Price | $ / shares		$ 3.50					$ 1
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member] | If Conversion Price $1.00 per Unit Rather Than $3.50 per Unit [Member]
Debt Conversion, Converted Instrument, Shares Issued | shares		1,071,432.5
David G. Schmidt v. Diffusion Pharmaceuticals, LLC [Member]
Operating Leases, Rent Expense, Net					$ 22,859
Debt Conversion, Original Debt, Amount		$ 1,500,000
Amended David G. Schmidt V Diffusion Pharmaceuticals LLC [Member] | If Conversion Price $1.00 per Unit Rather Than $3.50 per Unit [Member]
Debt Instrument, Convertible, Conversion Price | $ / shares			$ 1		$ 1
Debt Conversion, Converted Instrument, Shares Issued | shares	1,071,432.5
Amended David G. Schmidt V Diffusion Pharmaceuticals LLC [Member]
Loss Contingency, Damages Sought, Shares | shares			3,913,577
Loss Contingency, Damages Sought, Proceeds From Plaintiff			$ 1,071,432.50
Debt Conversion, Original Debt, Amount					$ 695,000

X

- Definition

The amount of cash the plaintiff seeks to pay for the exchange of the entity's shares in the legal matter.

+ References

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- Definition

The number of shares issued in exchange for the original debt being converted in a noncash (or part noncash) transaction. "Part noncash" refers to that portion of the transaction not resulting in cash receipts or payments in the period.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 50
-Paragraph 5
-URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4332-108586

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+ References

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-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 50
-Paragraph 3
-URI http://asc.fasb.org/extlink&oid=6367179&loc=d3e4304-108586

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The price per share of the conversion feature embedded in the debt instrument.

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-Publisher FASB
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-Topic 470
-SubTopic 20
-Section 50
-Paragraph 5
-Subparagraph (b)
-URI http://asc.fasb.org/extlink&oid=6928298&loc=SL6031898-161870

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Rental expense for the reporting period incurred under operating leases, including minimum and any contingent rent expense, net of related sublease income.

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-Name Accounting Standards Codification
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-SubTopic 20
-Section 50
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