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Note 11 - Fair Value Measurements (Details Textual)	Jan. 08, 2016 USD ($)	Jun. 30, 2016 USD ($)	Dec. 31, 2015 USD ($)
Fair Value, Inputs, Level 3 [Member]
Convertible Debt, Fair Value Disclosures		$ 1,700,000	$ 4,800,000
Diffusion LLC [Member]
Business Combination, Number of Contingent Value Rights per Share Called by Each Previously Held Share of Common Stock	1
Business Combination, Period Following Merger in Which Receipt of Cash for Discontinued Product Assets Would Trigger Contingent Value Right Payements	5 years
Business Combination, Contingent Value Right Payout Maximum	$ 50,000,000

X

- Definition

The maximum amount the reporting entity will pay to holders of contingent value rights related to a business acquisition.

+ References

No definition available.

+ Details

Name:	dffn_BusinessCombinationContingentValueRightPayoutMaximum
Namespace Prefix:	dffn_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

X

- Definition

The number of contingent value rights (non-transferable rights subject to certain limited exceptions to potentially receive certain cash payments in the event of specified contingencies) issued per share of each previously held shares of common stock as part of a business combination.

+ References

No definition available.

+ Details

Name:	dffn_BusinessCombinationNumberOfContingentValueRightsPerShareCalledByEachPreviouslyHeldShareOfCommonStock
Namespace Prefix:	dffn_
Data Type:	xbrli:integerItemType
Balance Type:	na
Period Type:	instant

X

- Definition

The period following a merger that, if the reporting entity receives net cash payments for the sale of any of the assets related to a discontinued product line, would trigger a required payment to holders of contingent value rights.

+ References

No definition available.

+ Details

Name:	dffn_BusinessCombinationPeriodFollowingMergerInWhichReceiptOfCashForDiscontinuedProductAssetsWouldTriggerContingentValueRightPayements
Namespace Prefix:	dffn_
Data Type:	xbrli:durationItemType
Balance Type:	na
Period Type:	duration

X

- Definition

Fair value portion of borrowing which can be exchanged for a specified number of another security at the option of the issuer or the holder, for example, but not limited to, the entity's common stock.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Convertible Security
-URI http://asc.fasb.org/extlink&oid=6509036

+ Details

Name:	us-gaap_ConvertibleDebtFairValueDisclosures
Namespace Prefix:	us-gaap_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

X

- Details

Name:	us-gaap_FairValueByFairValueHierarchyLevelAxis=us-gaap_FairValueInputsLevel3Member
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

X

- Details

Name:	us-gaap_BusinessAcquisitionAxis=dffn_DiffusionLLCMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type: