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Note 10 - Income Taxes (Details Textual) - USD ($) | 3 Months Ended | 9 Months Ended
--- | --- | ---
Sep. 30, 2016 | Sep. 30, 2015 | Sep. 30, 2016 | Sep. 30, 2015
In Process Research and Development Costs (IPR&D) [Member] |  |  |  |
Deferred Tax Liabilities, Net | $ 3,644,159 |  | $ 3,644,159 |
Impairment of Intangible Assets (Excluding Goodwill) |  |  | 961,000 |
RES-440 [Member] | Research and Development Expense [Member] |  |  |  |
Impairment of Intangible Assets (Excluding Goodwill) |  |  | 951,000 |
RES-440 [Member] |  |  |  |
Impairment of Intangible Assets (Excluding Goodwill) |  |  | 961,000 |
Abandonmnet of In-Process Research and Development Intangible Asset [Member] |  |  |  |
Income Tax Expense (Benefit) |  |  | 364,796 |
Income Tax Expense (Benefit) | $ (364,796) |  | $ (364,796) |

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