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Note 8 - Stock-based Compensation - Summary of Stock-basedCompensation Expense (Details) - USD ($) | 3 Months Ended | 9 Months Ended
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Sep. 30, 2016 | Sep. 30, 2015 | Sep. 30, 2016 | Sep. 30, 2015
Research and Development Expense [Member] |  |  |  |
Allocated Share-based Compensation Expense | $ 174,932 | $ 78,289 | $ 601,260 | $ 197,871
General and Administrative Expense [Member] |  |  |  |
Allocated Share-based Compensation Expense | 215,425 | 63,119 | 520,730 | 176,118
Allocated Share-based Compensation Expense | $ 390,357 | $ 141,408 | $ 1,121,990 | $ 373,989

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- Definition Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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