    <SEC-DOCUMENT>0001437749-16-033633-index.html : 20160610
    <SEC-HEADER>0001437749-16-033633.hdr.sgml : 20160610
    <ACCEPTANCE-DATETIME>20160610071258
    ACCESSION NUMBER:		0001437749-16-033633
    CONFORMED SUBMISSION TYPE:	DEF 14A
    PUBLIC DOCUMENT COUNT:		4
    CONFORMED PERIOD OF REPORT:	20160721
    FILED AS OF DATE:		20160610
    DATE AS OF CHANGE:		20160610
    EFFECTIVENESS DATE:		20160610

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Diffusion Pharmaceuticals Inc.
    		CENTRAL INDEX KEY:			0001053691
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				300645032
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEF 14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	000-24477
    		FILM NUMBER:		161707363

    	BUSINESS ADDRESS:
    		STREET 1:		2020 AVON COURT
    		STREET 2:		SUITE 4
    		CITY:			CHARLOTTESVILLE
    		STATE:			VA
    		ZIP:			22902
    		BUSINESS PHONE:		(434) 220-0718

    	MAIL ADDRESS:
    		STREET 1:		2020 AVON COURT
    		STREET 2:		SUITE 4
    		CITY:			CHARLOTTESVILLE
    		STATE:			VA
    		ZIP:			22902

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	RestorGenex Corp
    		DATE OF NAME CHANGE:	20140307

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Stratus Media Group, Inc
    		DATE OF NAME CHANGE:	20080722

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	FERIS INTERNATIONAL, INC.
    		DATE OF NAME CHANGE:	20080228
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEF 14A
    <SEQUENCE>1
    <FILENAME>dffn20160607_def14a.htm
    <DESCRIPTION>FORM DEF 14A
    <TEXT>
    Document 1 - file: dffn20160607_def14a.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>proxypage2.jpg
    <TEXT>
    Document 2 - file: proxypage2.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>proxypage1.jpg
    <TEXT>
    Document 3 - file: proxypage1.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>a1.jpg
    <TEXT>
    Document 4 - file: a1.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>