<SEC-DOCUMENT>0001053691-16-000005.txt : 20160121
<SEC-HEADER>0001053691-16-000005.hdr.sgml : 20160121
<ACCEPTANCE-DATETIME>20160121150320
ACCESSION NUMBER:		0001053691-16-000005
CONFORMED SUBMISSION TYPE:	D
PUBLIC DOCUMENT COUNT:		1
ITEM INFORMATION:		<ITEMS>06b
FILED AS OF DATE:		20160121
DATE AS OF CHANGE:		20160121
EFFECTIVENESS DATE:		20160121

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Diffusion Pharmaceuticals Inc.
		CENTRAL INDEX KEY:			0001053691
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				300645032
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		D
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	021-255678
		FILM NUMBER:		161353329

	BUSINESS ADDRESS:	
		STREET 1:		2020 AVON COURT
		STREET 2:		SUITE 4
		CITY:			CHARLOTTESVILLE
		STATE:			VA
		ZIP:			22902
		BUSINESS PHONE:		(434) 220-0718

	MAIL ADDRESS:	
		STREET 1:		2020 AVON COURT
		STREET 2:		SUITE 4
		CITY:			CHARLOTTESVILLE
		STATE:			VA
		ZIP:			22902

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	RestorGenex Corp
		DATE OF NAME CHANGE:	20140307

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Stratus Media Group, Inc
		DATE OF NAME CHANGE:	20080722

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	FERIS INTERNATIONAL, INC.
		DATE OF NAME CHANGE:	20080228
</SEC-HEADER>
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<SEQUENCE>1
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        <cik>0001053691</cik>
        <entityName>Diffusion Pharmaceuticals Inc.</entityName>
        <issuerAddress>
            <street1>2020 AVON COURT</street1>
            <street2>SUITE 4</street2>
            <city>CHARLOTTESVILLE</city>
            <stateOrCountry>VA</stateOrCountry>
            <stateOrCountryDescription>VIRGINIA</stateOrCountryDescription>
            <zipCode>22902</zipCode>
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        <issuerPhoneNumber>(434) 220-0718</issuerPhoneNumber>
        <jurisdictionOfInc>DELAWARE</jurisdictionOfInc>
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            <previousName>Stratus Media Group, Inc</previousName>
            <previousName>FERIS INTERNATIONAL, INC.</previousName>
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        <entityType>Corporation</entityType>
        <yearOfInc>
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            <value>2015</value>
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    <relatedPersonsList>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName>K.</middleName>
                <lastName>Kalergis</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2020 Avon Court</street1>
                <street2>Suite 4</street2>
                <city>Charlottesville</city>
                <stateOrCountry>VA</stateOrCountry>
                <stateOrCountryDescription>VIRGINIA</stateOrCountryDescription>
                <zipCode>22902</zipCode>
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                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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            <relatedPersonName>
                <firstName>Mark</firstName>
                <middleName>T.</middleName>
                <lastName>Giles</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2020 Avon Court</street1>
                <street2>Suite 4</street2>
                <city>Charlottesville</city>
                <stateOrCountry>VA</stateOrCountry>
                <stateOrCountryDescription>VIRGINIA</stateOrCountryDescription>
                <zipCode>22902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>John</firstName>
                <middleName>L.</middleName>
                <lastName>Gainer</lastName>
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                <street1>2020 Avon Court</street1>
                <street2>Suite 4</street2>
                <city>Charlottesville</city>
                <stateOrCountry>VA</stateOrCountry>
                <stateOrCountryDescription>VIRGINIA</stateOrCountryDescription>
                <zipCode>22902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
                <relationship>Director</relationship>
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            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Thomas</firstName>
                <middleName>S.</middleName>
                <lastName>Byrne</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2020 Avon Court</street1>
                <street2>Suite 4</street2>
                <city>Charlottesville</city>
                <stateOrCountry>VA</stateOrCountry>
                <stateOrCountryDescription>VIRGINIA</stateOrCountryDescription>
                <zipCode>22902</zipCode>
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                <firstName>Robert</firstName>
                <middleName>W.</middleName>
                <lastName>Adams</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2020 Avon Court</street1>
                <street2>Suite 4</street2>
                <city>Charlottesville</city>
                <stateOrCountry>VA</stateOrCountry>
                <stateOrCountryDescription>VIRGINIA</stateOrCountryDescription>
                <zipCode>22902</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
        </relatedPersonInfo>
        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Alan</firstName>
                <middleName>G.</middleName>
                <lastName>Levin</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2020 Avon Court</street1>
                <street2>Suite 4</street2>
                <city>Charlottesville</city>
                <stateOrCountry>VA</stateOrCountry>
                <stateOrCountryDescription>VIRGINIA</stateOrCountryDescription>
                <zipCode>22902</zipCode>
            </relatedPersonAddress>
            <relatedPersonRelationshipList>
                <relationship>Director</relationship>
            </relatedPersonRelationshipList>
            <relationshipClarification></relationshipClarification>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>Ben</firstName>
                <middleName>L.</middleName>
                <lastName>Shealy</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2020 Avon Court</street1>
                <street2>Suite 4</street2>
                <city>Charlottesville</city>
                <stateOrCountry>VA</stateOrCountry>
                <stateOrCountryDescription>VIRGINIA</stateOrCountryDescription>
                <zipCode>22902</zipCode>
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            <relatedPersonRelationshipList>
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        <relatedPersonInfo>
            <relatedPersonName>
                <firstName>David</firstName>
                <middleName>R.</middleName>
                <lastName>Jones</lastName>
            </relatedPersonName>
            <relatedPersonAddress>
                <street1>2020 Avon Court</street1>
                <street2>Suite 4</street2>
                <city>Charlottesville</city>
                <stateOrCountry>VA</stateOrCountry>
                <stateOrCountryDescription>VIRGINIA</stateOrCountryDescription>
                <zipCode>22902</zipCode>
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            <relatedPersonRelationshipList>
                <relationship>Executive Officer</relationship>
            </relatedPersonRelationshipList>
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    <offeringData>
        <industryGroup>
            <industryGroupType>Pharmaceuticals</industryGroupType>
        </industryGroup>
        <issuerSize>
            <revenueRange>$1 - $1,000,000</revenueRange>
        </issuerSize>
        <federalExemptionsExclusions>
            <item>06b</item>
        </federalExemptionsExclusions>
        <typeOfFiling>
            <newOrAmendment>
                <isAmendment>false</isAmendment>
            </newOrAmendment>
            <dateOfFirstSale>
                <value>2016-01-08</value>
            </dateOfFirstSale>
        </typeOfFiling>
        <durationOfOffering>
            <moreThanOneYear>false</moreThanOneYear>
        </durationOfOffering>
        <typesOfSecuritiesOffered>
            <isEquityType>true</isEquityType>
        </typesOfSecuritiesOffered>
        <businessCombinationTransaction>
            <isBusinessCombinationTransaction>true</isBusinessCombinationTransaction>
            <clarificationOfResponse>The offering is being made pursuant to the reverse merger between RestorGenex Corporation, and Diffusion Pharmaceuticals LLC, a privately held Virginia limited liability company.</clarificationOfResponse>
        </businessCombinationTransaction>
        <minimumInvestmentAccepted>1</minimumInvestmentAccepted>
        <salesCompensationList></salesCompensationList>
        <offeringSalesAmounts>
            <totalOfferingAmount>Indefinite</totalOfferingAmount>
            <totalAmountSold>85736378</totalAmountSold>
            <totalRemaining>Indefinite</totalRemaining>
            <clarificationOfResponse></clarificationOfResponse>
        </offeringSalesAmounts>
        <investors>
            <hasNonAccreditedInvestors>false</hasNonAccreditedInvestors>
            <totalNumberAlreadyInvested>181</totalNumberAlreadyInvested>
        </investors>
        <salesCommissionsFindersFees>
            <salesCommissions>
                <dollarAmount>0</dollarAmount>
            </salesCommissions>
            <findersFees>
                <dollarAmount>0</dollarAmount>
            </findersFees>
            <clarificationOfResponse></clarificationOfResponse>
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        <useOfProceeds>
            <grossProceedsUsed>
                <dollarAmount>0</dollarAmount>
            </grossProceedsUsed>
            <clarificationOfResponse></clarificationOfResponse>
        </useOfProceeds>
        <signatureBlock>
            <authorizedRepresentative>false</authorizedRepresentative>
            <signature>
                <issuerName>Diffusion Pharmaceuticals Inc.</issuerName>
                <signatureName>/s/David G. Kalergis</signatureName>
                <nameOfSigner>David G. Kalergis</nameOfSigner>
                <signatureTitle>Chairman &amp; CEO</signatureTitle>
                <signatureDate>2016-01-21</signatureDate>
            </signature>
        </signatureBlock>
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