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Note 7 - Other Assets - Summary of Other Assets (Details) - USD ($) | Dec. 31, 2016 | Dec. 31, 2015
--- | --- | ---
Offering costs | $ 180,456 |
Clinical studies deposits |  | 160,400
Other | 52,219 | 21,087
Total | $ 232,675 | $ 181,487

X
- Definition The amount of noncurrent assets classified as clinical studies deposits. + References No definition available. + Details
Name: | dffn_ClinicalStudiesDepositsNoncurrent
Namespace Prefix: | dffn_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | instant

X
- Definition The amount of noncurrent assets classified as offering costs. + References No definition available. + Details
Name: | dffn_OfferingCostsNoncurrent
Namespace Prefix: | dffn_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | instant

X
- Definition Amount of other miscellaneous assets expected to be realized or consumed after one year or normal operating cycle, if longer. + References No definition available. + Details
Name: | us-gaap_OtherAssetsMiscellaneousNoncurrent
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | instant

X
- Definition Amount of noncurrent assets classified as other. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 210 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.5-02.17) -URI http://asc.fasb.org/extlink&oid=6877327&loc=d3e13212-122682 + Details
Name: | us-gaap_OtherAssetsNoncurrent
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | debit
Period Type: | instant