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Note 12 - Stock-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2016
Notes Tables |
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] |
|  | Year ended December 31 , |
|  | 2016 |  |  | 2015 |
Research and development |  | $ | 674,643 |  |  | $ | 309,579 |
General and administrative |  |  | 716,425 |  |  |  | 284,596 |
Total stock-based compensation expense |  | $ | 1,391,068 |  |  | $ | 594,175 |
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block] |
|  | Number of Options |  |  | Weighted average exercise price per share |  |  | Weighted average remaining contractual life (in years) |  |  | Aggregate Intrinsic Value (A) |
Balance at January 1, 2016 |  |  | 1,495,615 |  |  | $ | 3.92 |  |  |  |  |  |  |  |  |
RestorGenex options outstanding |  |  | 301,156 |  |  |  | 40.13 |  |  |  |  |  |  |  |  |
Cancelled |  |  | (48,190 | ) |  |  | 61.30 |  |  |  |  |  |  |  |  |
Granted |  |  | 458,828 |  |  |  | 6.25 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2016 |  |  | 2,207,409 |  |  | $ | 8.09 |  |  |  | 7.8 |  |  |  | $94,599 |
Exercisable at December 31, 2016 |  |  | 1,446,121 |  |  | $ | 9.36 |  |  |  | 7.0 |  |  |  | $94,599 |
Vested and expected to vest at December 31, 2016 |  |  | 2,203,011 |  |  | $ | 8.09 |  |  |  | 7.8 |  |  |  | $94,599 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
| 2016 |  | 2015 |
Expected term (in years) | 5.76 | - | 7.48 |  |  | 5.76 |  |
Risk-free interest rate | 1.2% | - | 2.0% |  | 2.1% | - | 2.3% |
Expected volatility | 106.8% | - | 125.5% |  | 125.6% | - | 125.8% |
Dividend yield |  | 0% |  |  |  | 0% |  |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 + Details
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- Definition Tabular disclosure of the number and weighted-average exercise prices (or conversion ratios) for share options (or share units) that were outstanding at the beginning and end of the year, vested and expected to vest, exercisable or convertible at the end of the year, and the number of share options or share units that were granted, exercised or converted, forfeited, and expired during the year. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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