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Note 6 - Goodwill and Intangible Assets (Details Textual) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Aug. 31, 2016 | Dec. 31, 2016 | Dec. 31, 2015
Income Tax Expense (Benefit) |  | $ (364,796) |
Abandonmnet of In-Process Research and Development Intangible Asset [Member] |  |  |
Income Tax Expense (Benefit) |  | 400,000 |
RES-440 [Member] |  |  |
Impairment of Intangible Assets (Excluding Goodwill) |  | 961,000 |
RES-440 [Member] | Research and Development Expense [Member] |  |  |
Impairment of Intangible Assets (Excluding Goodwill) | $ 1,000,000 | $ 1,000,000 |

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- Definition The amount of impairment loss recognized in the period resulting from the write-down of the carrying amount of an intangible asset (excluding goodwill) to fair value. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 3 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16373-109275 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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