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Note 14 - Income Taxes - Changes in Valuation Allowance (Details) | 12 Months Ended
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Dec. 31, 2016 USD ($)
Valuation allowance at beginning of year | $ 0
Changes recorded to income tax provision | 5,017,047
Changes recorded in purchase accounting | (11,159,347)
Valuation allowance at end of year | $ 16,176,394

X
- Definition Amount of increase (decrease) in the valuation allowance for deferred tax assets due to income tax provision. + References No definition available. + Details
Name: | dffn_DeferredTaxAssetsValuationAllowanceProvision
Namespace Prefix: | dffn_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

X
- Definition Amount of increase (decrease) in the valuation allowance for deferred tax assets due to purchase accounting. + References No definition available. + Details
Name: | dffn_DeferredTaxAssetsValuationAllowancePurchaseAccounting
Namespace Prefix: | dffn_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | duration

X
- Definition Amount of deferred tax assets for which it is more likely than not that a tax benefit will not be realized. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32537-109319 + Details
Name: | us-gaap_DeferredTaxAssetsValuationAllowance
Namespace Prefix: | us-gaap_
Data Type: | xbrli:monetaryItemType
Balance Type: | credit
Period Type: | instant