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Note 2 - Liquidity (Details Textual) - Subsequent Event [Member] $ in Millions	Mar. 14, 2017 USD ($)
Purchase Agreement, Maximum Amount of Securities That May Be Sold	$ 1.0
Purchase Agreement, Maximum Amount of Securities That May Be Sold, Increased Amount	25.0
Private Placement [Member] | Series A Convertible Preferred Stock [Member]
Proceeds from Issuance of Private Placement	14.1
Payments of Stock Issuance Costs	$ 1.7

X

- Definition

The maximum amount of securities that may be sold under the purchase agreement.

+ References

No definition available.

+ Details

Name:	dffn_PurchaseAgreementMaximumAmountOfSecuritiesThatMayBeSold
Namespace Prefix:	dffn_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

X

- Definition

The increased maximum amount of securities that may be sold under the purchase agreement.

+ References

No definition available.

+ Details

Name:	dffn_PurchaseAgreementMaximumAmountOfSecuritiesThatMayBeSoldIncreasedAmount
Namespace Prefix:	dffn_
Data Type:	xbrli:monetaryItemType
Balance Type:	credit
Period Type:	instant

X

- Definition

The cash outflow for cost incurred directly with the issuance of an equity security.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Financing Activities
-URI http://asc.fasb.org/extlink&oid=6513228

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 15
-URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3291-108585

+ Details

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Namespace Prefix:	us-gaap_
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Balance Type:	credit
Period Type:	duration

X

- Definition

The cash inflow associated with the amount received from entity's raising of capital via private rather than public placement.

+ References

Reference 1: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Glossary Financing Activities
-URI http://asc.fasb.org/extlink&oid=6513228

Reference 2: http://www.xbrl.org/2003/role/presentationRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 230
-SubTopic 10
-Section 45
-Paragraph 14
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585

+ Details

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Namespace Prefix:	us-gaap_
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Balance Type:	debit
Period Type:	duration

X

- Details

Name:	us-gaap_SubsequentEventTypeAxis=us-gaap_SubsequentEventMember
Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

X

- Details

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Namespace Prefix:
Data Type:	na
Balance Type:
Period Type:

X

- Details

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Namespace Prefix:
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