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Document And Entity Information - shares
 3 Months Ended
Mar. 31, 2017
May 05, 2017
Document And Entity Information    
Entity Registrant Name Diffusion Pharmaceuticals Inc.  
Entity Central Index Key 0001053691  
Trading Symbol dffn  
Current Fiscal Year End Date --12-31  
Entity Filer Category Smaller Reporting Company  
Entity Common Stock, Shares Outstanding (in shares)   10,345,637
Document Type 10-Q  
Document Period End Date Mar. 31, 2017  
Document Fiscal Year Focus 2017  
Document Fiscal Period Focus Q1  
Amendment Flag false