    <SEC-DOCUMENT>0001437749-17-004538-index.html : 20170315
    <SEC-HEADER>0001437749-17-004538.hdr.sgml : 20170315
    <ACCEPTANCE-DATETIME>20170315090939
    ACCESSION NUMBER:		0001437749-17-004538
    CONFORMED SUBMISSION TYPE:	8-K
    PUBLIC DOCUMENT COUNT:		16
    CONFORMED PERIOD OF REPORT:	20170313
    ITEM INFORMATION:		Entry into a Material Definitive Agreement
    ITEM INFORMATION:		Unregistered Sales of Equity Securities
    ITEM INFORMATION:		Material Modifications to Rights of Security Holders
    ITEM INFORMATION:		Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year
    ITEM INFORMATION:		Financial Statements and Exhibits
    FILED AS OF DATE:		20170315
    DATE AS OF CHANGE:		20170315

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Diffusion Pharmaceuticals Inc.
    		CENTRAL INDEX KEY:			0001053691
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				300645032
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		8-K
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-37942
    		FILM NUMBER:		17689981

    	BUSINESS ADDRESS:
    		STREET 1:		2020 AVON COURT
    		STREET 2:		SUITE 4
    		CITY:			CHARLOTTESVILLE
    		STATE:			VA
    		ZIP:			22902
    		BUSINESS PHONE:		(434) 220-0718

    	MAIL ADDRESS:
    		STREET 1:		2020 AVON COURT
    		STREET 2:		SUITE 4
    		CITY:			CHARLOTTESVILLE
    		STATE:			VA
    		ZIP:			22902

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	RestorGenex Corp
    		DATE OF NAME CHANGE:	20140307

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Stratus Media Group, Inc
    		DATE OF NAME CHANGE:	20080722

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	FERIS INTERNATIONAL, INC.
    		DATE OF NAME CHANGE:	20080228
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>8-K
    <SEQUENCE>1
    <FILENAME>dffn20170314_8k.htm
    <DESCRIPTION>FORM 8-K
    <TEXT>
    Document 1 - file: dffn20170314_8k.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-3.1
    <SEQUENCE>2
    <FILENAME>ex3-1.htm
    <DESCRIPTION>EXHIBIT 3.1
    <TEXT>
    Document 2 - file: ex3-1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-4.1
    <SEQUENCE>3
    <FILENAME>ex4-1.htm
    <DESCRIPTION>EXHIBIT 4.1
    <TEXT>
    Document 3 - file: ex4-1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.1
    <SEQUENCE>4
    <FILENAME>ex10-1.htm
    <DESCRIPTION>EXHIBIT 10.1
    <TEXT>
    Document 4 - file: ex10-1.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-10.2
    <SEQUENCE>5
    <FILENAME>ex10-2.htm
    <DESCRIPTION>EXHIBIT 10.2
    <TEXT>
    Document 5 - file: ex10-2.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>a11.jpg
    <TEXT>
    Document 6 - file: a11.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>a10.jpg
    <TEXT>
    Document 7 - file: a10.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>a9.jpg
    <TEXT>
    Document 8 - file: a9.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>a8.jpg
    <TEXT>
    Document 9 - file: a8.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>a7.jpg
    <TEXT>
    Document 10 - file: a7.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>a6.jpg
    <TEXT>
    Document 11 - file: a6.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>a5.jpg
    <TEXT>
    Document 12 - file: a5.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>a4.jpg
    <TEXT>
    Document 13 - file: a4.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>a3.jpg
    <TEXT>
    Document 14 - file: a3.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>15
    <FILENAME>a2.jpg
    <TEXT>
    Document 15 - file: a2.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>16
    <FILENAME>a1.jpg
    <TEXT>
    Document 16 - file: a1.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>