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Note 10 - Convertible Preferred Stock and Stockholder's Equity (Tables) | 12 Months Ended
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Dec. 31, 2017
Notes Tables |
Schedule of Warrants Outstanding to Acquire Shares of Common Stock [Table Text Block] |
|  | Outstanding |  |  | Range of exercise price per share |
Common stock warrants issued prior to Merger |  |  | 447,721 |  |  | $20.00 | - | $49.00 |
Common stock warrants issued in Series A |  |  | 13,555,887 |  |  | $2.22 |
|  |  | 14,003,608 |  |  |  |  |  |

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