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Note 4 - Acquisition (Details Textual) - USD ($) |  | 12 Months Ended
--- | --- | ---
Jan. 08, 2016 | Dec. 31, 2017 | Dec. 31, 2016
Stock Issued During Period, Shares, Issued for Services |  | 17,606 | 45,643
Stock Issued During Period, Value, Issued for Services |  | $ 50,000 | $ 1,409,363
Share-based Compensation |  | 1,240,551 | 1,391,068
Executive Officers [Member] |  |  |
Severance Costs | $ 3,000,000 | 0 |
RES-529 [Member] |  |  |
Intangible Assets, Net (Excluding Goodwill) |  | 8,600,000 |
RES-440 [Member] |  |  |
Intangible Assets, Net (Excluding Goodwill) |  | $ 1,000,000 |
Diffusion LLC [Member] |  |  |
Business Combination, Number of Shares Called by Each Previously Held Unit of Membership Interest | 0.3652658 |  |
Business Combination, Period Following Merger in Which Receipt of Cash for Discontinued Product Assets Would Trigger Contingent Value Right Payements | 5 years |  |
Diffusion LLC [Member] | Employee Stock Option [Member] |  |  |
Share-based Compensation | $ 2,700,000 |  |
Diffusion LLC [Member] | Financial Adviser [Member] |  |  |
Stock Issued During Period, Shares, Issued for Services | 46,000 |  |
Stock Issued During Period, Value, Issued for Services | $ 500,000 |  |
Diffusion LLC [Member] | Success Fee Agreement Costs [Member] |  |  |
Payments for Other Fees | $ 1,100,000 |  |
Diffusion LLC [Member] | Acquisition-related Costs [Member] |  |  |
Business Combination, Acquisition Related Costs |  |  | $ 1,600,000
Diffusion LLC [Member] | Former Equity Holders of Diffusion LLC [Member] |  |  |
Percentage of Common Stock Outstanding Owned | 84.10% |  |

X
- Definition Number of shares of the reporting entity's common stock into which each previously held unit of membership interest may be converted. + References No definition available. + Details
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- Definition The period following a merger that, if the reporting entity receives net cash payments for the sale of any of the assets related to a discontinued product line, would trigger a required payment to holders of contingent value rights. + References No definition available. + Details
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- Definition This element represents acquisition-related costs incurred to effect a business combination which costs have been expensed during the period. Such costs include finder's fees; advisory, legal, accounting, valuation, and other professional or consulting fees; general administrative costs, including the costs of maintaining an internal acquisitions department; and may include costs of registering and issuing debt and equity securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 805 -SubTopic 10 -Section 25 -Paragraph 23 -URI http://asc.fasb.org/extlink&oid=84229725&loc=d3e1043-128460 + Details
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- Definition Sum of the carrying amounts of all intangible assets, excluding goodwill, as of the balance sheet date, net of accumulated amortization and impairment charges. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 45 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6388964&loc=d3e16212-109274 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 350 -SubTopic 30 -Section 50 -Paragraph 2 -Subparagraph ((a)(1),(b)) -URI http://asc.fasb.org/extlink&oid=66006027&loc=d3e16323-109275 + Details
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- Definition Amount of expenses for special or contractual termination benefits provided to current employees involuntarily terminated under a benefit arrangement associated exit or disposal activities pursuant to an authorized plan. Excludes expenses related to one-time termination benefits, a discontinued operation or an asset retirement obligation. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SAB Topic 5.P.4(b)) -URI http://asc.fasb.org/extlink&oid=27011515&loc=d3e140904-122747 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=6394359&loc=d3e17939-110869 Reference 4: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 420 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 5.P.3) -URI http://asc.fasb.org/extlink&oid=27011515&loc=d3e140864-122747 + Details
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