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Note 13 - Income Taxes (Details Textual) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Aug. 31, 2016 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent |  |  | 34.00% | 34.00%
Deferred Tax Liabilities, Net |  |  | $ 2,223,678 | $ 3,279,363
Income Tax Expense (Benefit) |  |  | (1,055,685) | (364,796)
Income Tax Expense (Benefit), Continuing Operations, Adjustment of Deferred Tax (Asset) Liability |  |  | (1,100,000) |
Unrecognized Tax Benefits |  |  | $ 0 | 0
Abandonmnet of In-Process Research and Development Intangible Asset [Member] |  |  |  |
Income Tax Expense (Benefit) |  |  |  | (400,000)
In Process Research and Development Costs (IPR&D) [Member] |  |  |  |
Deferred Tax Liabilities, Net |  |  |  | 3,600,000
RES-440 [Member] | Research and Development Expense [Member] |  |  |  |
Impairment of Intangible Assets (Excluding Goodwill) | $ 1,000,000 |  |  | $ 1,000,000
Scenario, Forecast [Member] |  |  |  |
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent |  | 21.00% |  |

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