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Note 9 - Commitments and Contingencies (Details Textual) - USD ($) |  | 12 Months Ended
--- | --- | ---
Sep. 27, 2016 | Dec. 31, 2017 | Dec. 31, 2016
Research and Development Expense |  | $ 5,088,621 | $ 7,252,241
Litigation Settlement, Expense |  |  | 2,500,000
The 2016 Convertible Notes [Member] | Settlement Agreement [Member] |  |  |
Debt Instrument, Face Amount | $ 1,900,000 |  |
Debt Instrument, Convertible, Conversion Price | $ 3.50 |  |
Litigation Settlement, Expense | $ 2,500,000 |  |
Arrangement With Clinical Research Organization [Member] |  |  |
Research and Development Expense |  | 1,000,000 |
Prepaid Research and Development Expense |  | 800,000 |
Charlottesville, Virginia [Member] | Leasehold Improvements [Member] |  |  |
Property, Plant and Equipment, Additions |  | 400,000 |
Charlottesville, Virginia [Member] | Building [Member] |  |  |
Operating Leases, Rent Expense, Net |  | $ 100,000 | $ 66,000

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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI http://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 + Details
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