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Note 11 - Stock-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2017
Notes Tables |
Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block] |
|  | Year ended December 31, |
|  | 2017 |  |  | 2016 |
Research and development |  | $ | 95,040 |  |  | $ | 674,643 |
General and administrative |  |  | 1,145,511 |  |  |  | 716,425 |
Total stock-based compensation expense |  | $ | 1,240,551 |  |  | $ | 1,391,068 |
Share-based Compensation, Stock Options, Activity [Table Text Block] |
|  | Number of Options |  |  | Weighted average exercise price per share |  |  | Weighted average remaining contractual life (in years) |  |  | Aggregate Intrinsic Value (A) |
Balance at January 1, 2016 |  |  | 1,495,615 |  |  | $ | 3.92 |  |  |  |  |  |  |  |  |
RestorGenex options outstanding |  |  | 301,156 |  |  | $ | 40.13 |  |  |  |  |  |  |  |  |
Cancelled |  |  | (48,190 | ) |  | $ | 61.30 |  |  |  |  |  |  |  |  |
Granted |  |  | 458,828 |  |  | $ | 6.25 |  |  |  |  |  |  |  |  |
Balance at January 1, 2017 |  |  | 2,207,409 |  |  | $ | 8.09 |  |  |  | 7.8 |  |  | $ | 94,599 |
Granted |  |  | 350,041 |  |  |  | 2.46 |  |  |  |  |  |  |  |  |
Expired |  |  | (1,461 | ) |  |  | 15.00 |  |  |  |  |  |  |  |  |
Outstanding at December 31, 2017 |  |  | 2,555,989 |  |  | $ | 7.32 |  |  |  | 7.13 |  |  | $ | 4,734 |
Exercisable at December 31, 2017 |  |  | 1,858,073 |  |  | $ | 8.25 |  |  |  | 6.49 |  |  | $ | 4,734 |
Vested and expected to vest at December 31, 2017 |  |  | 2,555,989 |  |  | $ | 7.32 |  |  |  | 7.13 |  |  | $ | 4,734 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | 2017 |  |  | 2016 |
Expected term (in years) |  | 5.27 | — | 6.00 |  |  | 5.76 | — | 7.48 |
Risk-free interest rate |  | 1.8% | — | 2.4% |  |  | 1.2% | — | 2.0% |
Expected volatility |  | 109.8% | — | 136.7% |  |  | 106.8% | — | 125.5% |
Dividend yield |  | — |  |  | — |

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- Definition Tabular disclosure of the allocation of equity-based compensation costs to a given line item on the balance sheet and income statement for the period. This may include the reporting line for the costs and the amount capitalized and expensed. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 1 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5047-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SAB Topic 14.F) -URI http://asc.fasb.org/extlink&oid=27013229&loc=d3e301413-122809 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI http://asc.fasb.org/extlink&oid=96867065&loc=d3e5070-113901 + Details
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