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Note 3 - Basis of Presentation and Summary of Significant Accounting Policies (Tables)
 12 Months Ended
Dec. 31, 2017
Notes Tables  
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
   
Year ended December 31,
  
   
2017
    
2016
  
Basic net loss per common share calculation:
                
Net loss
   $
(1,364,518
)
   $
(18,036,619
)
Accretion of Series A cumulative preferred dividends
    
(1,252,394
)
    
—
  
Net loss attributable to common stockholders
   $
(2,616,912
)
   $
(18,036,619
)
                 
Weighted average shares outstanding, basic
    
12,447,641
      
10,232,791
  
Net loss per share of common, basic
   $
(0.21
)
   $
(1.76
)
Diluted net loss per common share calculation:
                
Net loss attributable to common stockholders
    
(2,616,912
)
    
(18,036,619
)
Change in fair value of warrant liability
    
(22,072,322
)
    
—
  
Diluted net loss
    
(24,689,234
)
    
(18,036,619
)
Weighted average common shares outstanding, basic
    
12,447,641
      
10,232,791
  
Common stock equivalents arising from warrants
    
307,675
      
—
  
Common stock equivalents
    
12,755,316
      
10,232,791
  
Net loss per share of common stock, diluted
   $
(1.94
)
   $
(1.76
)
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
December 31,
  
   
2017
    
2016
  
Convertible debt
    
214,385
      
757,909
  
Common stock warrants
    
447,721
      
460,721
  
Convertible preferred stock
    
8,306,278
      
—
  
Stock options
    
2,555,989
      
2,207,409
  
Unvested restricted stock awards
    
3,066
      
9,204
  
     
11,527,439
      
3,435,243