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Note 3 - Basis of Presentation and Summary of Significant Accounting Policies (Tables)
3 Months Ended
Mar. 31, 2018
Notes Tables  
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
   
March 31,
 
   
2018
   
2017
 
Convertible debt
   
214,880
     
766,351
 
Convertible preferred stock
   
     
12,376,329
 
Common stock warrants
   
31,707,223
     
14,016,608
 
Stock options
   
3,053,797
     
2,304,132
 
Unvested restricted stock awards
   
1,533
     
7,665
 
     
34,977,433
     
29,471,085